專任教師 – 細菌學

許博琛助理教授
Po-Chen Hsu

 

 

學歷

  • PhD. (2007−2013) in Molecular and Cellular Biology
    Institute of Molecular and Cellular Biology, National Tsing-Hua University, Taiwan. / Chung-Yu Lan (藍忠昱老師) Lab.
  • MS. (2006−2007), then accepted into the Direct-Ph.D. program.
    Institute of Molecular and Cellular Biology, National Tsing-Hua University, Taiwan. / Chung-Yu Lan (藍忠昱老師) Lab.
  • BS. (2002-2006)
    Department of Life Science, National Tsing-Hua University, Taiwan.
  • Undergraduate researcher/bachelor’s thesis (2004−2006)
    Institute of Molecular Medicine, National Tsing-Hua University, Taiwan. / Kuan Rong Lee (李寬容老師) Lab.
 

經歷

  • 國立陽明大學 微生物及免疫學研究所 助理教授 (2025~迄今)
  • 中央研究院 分子生物研究所 資深專案博士後研究員 (2020-2025)
  • 中央研究院 分子生物研究所 博士後研究員 (2013-2020)
 
 
 

獲獎 :

  • 2025 H&J Youth Chair Professor (2025年 華仁青年講座教授)
  • 2022 NSTC Academic Research Award for Postdoc Researchers (國科會111年度博士後研究人員學術研究獎)
  • 2015 Academia Sinica Regular Postdoctoral Scholar Program (中研院一般博士後研究學者) Fellowship

研討會主持人/主辦人 :

  • 2025 Taiwan Yeast Meeting Organizing Committee
 

論文

  • Hsu, P.-C.*, Lu, T.-C., Hung, P.-H., and Leu, J.-Y.* (2024) Protein moonlighting by a target gene dominates phenotypic divergence of the Sef1 transcriptional regulatory network in yeasts. Nucleic Acids Res. 52(22):13914-13930. (* co-corresponding author) (6/313 in Biochemistry & Molecular Biology, 2023 JCR)
  • Hsu, P.-C.*, Cheng, Y.-H., Liao, C.-W., Litan, R.R.R., Jhou, Y.-T., Opoc, F.J.G., Amine, A.A.A., and Leu, J.-Y. (2023) Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network. EMBO Reports 24(6):e56019 (* corresponding author)(60/313 in Biochemistry & Molecular Biology, 2023 JCR)
  • Chou, J.-Y.*, Hsu, P.-C., and Leu, J.-Y.* (2022) Enforcement of postzygotic species boundaries in the fungal kingdom. Microbiology and molecular biology reviews 86(4), e0009822 (Review article)
  • Hsu, P.-C.*, Lu, T.-C., Hung, P.-H., Jhou, Y.-T., Amine, A.A.A., Liao, C.-W., Leu, J.-Y.* (2021) Plastic Rewiring of Sef1 Transcriptional Networks and the Potential of Nonfunctional Transcription Factor Binding in Facilitating Adaptive Evolution. Molecular Biology and Evolution 38(11): 4732-4747 (* co-corresponding author) (4/54 in Evolutionary Biology, 2023 JCR)
  • Amine, A.A.A., Liao, C.-W., Hsu, P.-C., Opoc, F.J.G., Leu, J.-Y. (2021) Experimental evolution improves mitochondrial genome quality control in Saccharomyces cerevisiae and extends its replicative lifespan. Current Biology 31(16):3663-3670e4 (3/109 in Biology, 2023 JCR)
  • Chen, Y.-Y., Chao, C.-C., Liu, F.-C., Hsu, P.-C., Chen, H.-F., Peng, S.-C., Chuang, Y.-J., Lan, C.-Y., Hsieh, W.-P., and Wong, D.S.-H.* (2013) Dynamic transcript profiling of Candida albicans infection in zebrafish: a pathogen-host interaction study. PLoS One 8(9):e72483
  • Hsu, P.-C., Chao, C.-C., Yang, C.-Y., Ye, Y.-L., Liu, F.-C., Chuang, Y.-J., and Lan, C.-Y.* (2013) Diverse Hap43-independent functions of Candida albicans CCAAT-binding complex. Eukaryot Cell 12(6):804-15
  • Tsai, P.-W., Chen, Y.-T., Hsu, P.-C., and Lan, C.-Y.* (2013) Study of Candida albicans and its interactions with the host: A mini-review. BioMedicine 3:51-64
  • Hsu, P.-C., Yang, C.-Y., and Lan, C.-Y.* (2011) Candida albicans Hap43 is a repressor induced under low-iron conditions and is essential for iron-responsive transcriptional regulation and virulence. Eukaryot Cell 10(2):207-225
  • Chao, C.-C., Hsu, P.-C., Jen, C.-F., Chen, I.-H., Wang, C.-H., Cham, H.-C., Tsai, P.-W., Tung, K.-C., Wang, C.-H., Lan, C.-Y.*, and Chuang, Y.-J.* (2010) Zebrafish as a model host for Candida albicans Infect Immun 78(6): 2512-2521

計畫Research Projects:

2025-2028新進人員研究計畫(個別型): 酵母菌物種的轉錄調控網路重組分析

「Evo-Devo」的理論強調了基因表達調控在物種演化中的重要作用，提出轉錄網路重組可能是表現型多樣性的重要驅動因素的假說。過去對多種酵母物種進行的比較性研究顯示，在物種進化歷史中發生了許多大規模的轉錄網路重組。然而，這些演化事件的潛在分子機制及其背後的演化驅動力仍未被充分了解。除此之外，有關轉錄網路重組的研究大多集中於順式調控DNA序列上。為了填補這些研究上的真空地帶，我計劃將重點放在異側作用轉錄因子及其功能上，以期闡明推動轉錄網路重組的演化驅動力。真菌物種的鐵養份轉錄調控網路在數億年的生物多樣性演化分歧中顯示出顯著的轉錄網路重組特徵，為探究這些關於轉錄網路重組的學術題目提供了極具前景的研究目標。我將以研究轉錄激活因子Sef1為開始進行本研究計畫。Sef1被推測扮演了在真菌的鐵養份調控網路演化過程中的重要角色。我計劃以此為切入點並將研究擴展到更多有潛力的轉錄因子及酵母菌物種上。

2025-2028 Research Project for Newly-recruited Personnel (Individual Research): Transcriptional Rewiring in Yeasts Abstract:

The “Evo-Devo” theory emphasizes the significant role of regulatory genes in evolution, proposing that transcriptional rewiring may be a crucial driver of phenotypic diversity. Comparative analyses across various yeast species have identified numerous large-scale rewiring events throughout evolutionary history. However, the mechanisms underlying these events and the forces driving them remain insufficiently understood. Furthermore, most research on transcriptional rewiring has concentrated on cis-regulatory sequences. To address these gaps, I intend to focus on trans-acting factors and their functional roles in elucidating the driving forces behind transcriptional rewiring. The fungal iron-regulatory networks, which exhibit substantial transcriptional rewiring signatures spanning several hundred million years of diversity, offer promising targets for investigations aiming to address these questions. I will begin this project with a transcriptional activator, Sef1, a potential key player in the evolution of fungal iron-regulatory networks, and aims to expand the investigation to more transcription factors (TFs) and yeast species.

研究方向 ：

本研究以多種酵母菌為模式生物，綜合遺傳學、分子生物學、生物化學及系統生物學之方法，以深入解析微生物學、醫學及演化生物學相關議題。

Our current research interests include:

  • Transcriptional rewiring (轉錄因子調控網路重組的分子機制)
  • Experimental evolution (實驗室內的酵母菌人工演化)
  • Mitochondrial genome quality control & disease (粒線體基因體品管機制與疾病的關聯)
  • Yeast Pathogenesis (酵母菌病源體的致病機制)
  • Molecular basis of complex traits (受多重因子影響性狀之分子機制)
  • Pleiotropy (酵母菌基因多效性)
  • Cell density-dependent phenotypes (細胞濃度依賴性之酵母菌表現型)

Please refer to the links for introduction and PI’s talk about our research:

  • 「發現新的轉錄因子調控網路演化軌跡」https://www.sinica.edu.tw/News_Content/36/2829
  • 「生命科學院週三中午有約」2.26新進教師 許博琛助理教授 https://www.youtube.com/watch?v=qdY7tlf5oaY

實驗室成員Lab Members：

    • Applications are open to both domestic and international students.
    • If you are interested in joining us and being the pioneer lab members, please send your CV, transcripts, and thesis to: pchsu2025@nycu.edu.tw
    • Aug 2025 updates: We are going to have 2~3 international lab members in the coming spring semester in 2026.

實驗室照片

Aug 2025 updates: R405 Yeast Lab under construction!
(The R405 laboratory is expected to be operational by late 2025)