{"id":1064,"date":"2025-06-24T12:29:54","date_gmt":"2025-06-24T04:29:54","guid":{"rendered":"https:\/\/imi.nycu.edu.tw\/%e5%bc%b5%e4%bd%a9%e9%9d%96%e6%95%99%e6%8e%88\/"},"modified":"2026-03-25T15:07:32","modified_gmt":"2026-03-25T07:07:32","slug":"pei-ching-chang","status":"publish","type":"post","link":"https:\/\/imi.nycu.edu.tw\/en\/pei-ching-chang\/","title":{"rendered":"Pei-Ching Chang"},"content":{"rendered":"<div class=\"row\"  id=\"row-469367827\">\n\n\t<div id=\"col-949886431\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<ul>\n<li>Professor<br \/>\nInstitute of Microbiology and Immunology<\/li>\n<li>Research Interests: Epigenomics; Virology; Cancer Immunology; Cancer Metabolism<\/li>\n<li>Office: Room R306, Biomedical Building<\/li>\n<li>Tel (Office): +886-2-2826-7111<\/li>\n<li>Tel (Laboratory): +886-2-2826-7000 ext. 65617<\/li>\n<li>E-mail: pcchang@nycu.edu.tw<\/li>\n<li>ORCID:\u00a0<a href=\"https:\/\/orcid.org\/0000-0001-8665-5494\">0000-0001-8665-5494<\/a><\/li>\n<\/ul>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-1253858483\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_954623438\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"795\" height=\"1024\" src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5f35\u4f69\u9756\u6559\u6388_Pei-Ching-Chang-795x1024.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5f35\u4f69\u9756\u6559\u6388_Pei-Ching-Chang-795x1024.jpg 795w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5f35\u4f69\u9756\u6559\u6388_Pei-Ching-Chang-233x300.jpg 233w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5f35\u4f69\u9756\u6559\u6388_Pei-Ching-Chang-768x989.jpg 768w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5f35\u4f69\u9756\u6559\u6388_Pei-Ching-Chang-1193x1536.jpg 1193w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5f35\u4f69\u9756\u6559\u6388_Pei-Ching-Chang.jpg 1200w\" sizes=\"auto, (max-width: 795px) 100vw, 795px\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_954623438 {\n  width: 100%;\n}\n<\/style>\n\t<\/div>\n\t\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<\/div>\n\n\t\t<div class=\"tabbed-content\">\n\t\t\t\n\t\t\t<ul class=\"nav nav-tabs nav-uppercase nav-size-normal nav-left\" role=\"tablist\"><li id=\"tab-professional-experience\" class=\"tab active has-icon\" role=\"presentation\"><a href=\"#tab_professional-experience\" role=\"tab\" aria-selected=\"true\" aria-controls=\"tab_professional-experience\"><span>Professional Experience<\/span><\/a><\/li>\n<li id=\"tab-selected-honors-and-awards\" class=\"tab has-icon\" role=\"presentation\"><a href=\"#tab_selected-honors-and-awards\" tabindex=\"-1\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab_selected-honors-and-awards\"><span>Selected Honors and Awards<\/span><\/a><\/li>\n<li id=\"tab-publications-and-research-projects\" class=\"tab has-icon\" role=\"presentation\"><a href=\"#tab_publications-and-research-projects\" tabindex=\"-1\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab_publications-and-research-projects\"><span>Publications and Research Projects<\/span><\/a><\/li>\n<li id=\"tab-laboratory-overview\" class=\"tab has-icon\" role=\"presentation\"><a href=\"#tab_laboratory-overview\" tabindex=\"-1\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab_laboratory-overview\"><span>Laboratory Overview<\/span><\/a><\/li><\/ul><div class=\"tab-panels\"><div id=\"tab_professional-experience\" class=\"panel active entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-professional-experience\">\n<h2><strong>Education<\/strong><\/h2>\n<p>\u535a\u58eb\u00a0\u00a0 \u570b\u7acb\u967d\u660e\u5927\u5b78\u00a0\u00a0\u00a0 \u751f\u5316\u66a8\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240<br \/>\n\u78a9\u58eb\u00a0\u00a0 \u85e5\u7406\u5b78\u7814\u7a76\u6240 \u570b\u7acb\u967d\u660e\u5927\u5b78<\/p>\n<h2><strong>Professional Experience<\/strong><\/h2>\n<p>\u570b\u7acb\u967d\u660e\u5927\u5b78\u5fae\u751f\u7269\u53ca\u514d\u75ab\u5b78\u7814\u7a76\u6240 \u7279\u8058\u6559\u6388 (2021~2023)<br \/>\nLerner Research Institute, Cleveland Clinic\u8a2a\u554f\u5b78\u8005 (2021~\u8fc4\u4eca)<br \/>\n\u570b\u7acb\u967d\u660e\u5927\u5b78\u5fae\u751f\u7269\u53ca\u514d\u75ab\u5b78\u7814\u7a76\u6240 \u6559\u6388 (2020~\u8fc4\u4eca)<br \/>\n\u570b\u7acb\u967d\u660e\u5927\u5b78\u5fae\u751f\u7269\u53ca\u514d\u75ab\u5b78\u7814\u7a76\u6240 \u526f\u6559\u6388 (2016~2020)<br \/>\n\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u50b3\u67d3\u75c5\u8207\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3 \u526f\u7814\u7a76\u54e1 (2016~2019)<br \/>\nUniversity of South California (USC), School of Pharmacy \u8a2a\u554f\u5b78\u8005 (2015~2016)<br \/>\n\u570b\u7acb\u967d\u660e\u5927\u5b78 \u5fae\u751f\u7269\u53ca\u514d\u75ab\u5b78\u7814\u7a76\u6240 \u52a9\u7406\u6559\u6388 (2011~2016)<\/p>\n<\/div>\n<div id=\"tab_selected-honors-and-awards\" class=\"panel entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-selected-honors-and-awards\">\n<h2><strong>Awards<\/strong><\/h2>\n<p>111-114\u5b78\u5e74\u5ea6: \u7e3e\u512a\u6559\u7814\u4eba\u54e1<br \/>\n110\u5b78\u5e74\u5ea6: \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u7279\u8058\u6559\u6388<br \/>\n110\u5b78\u5e74\u5ea6: \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u7d42\u751f\u514d\u8a55\u6559\u5e2b<br \/>\n110\u5b78\u5e74\u5ea6: \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u8cc7\u6df1\u512a\u826f\u6559\u5e2b<br \/>\n110-111\u5b78\uf98e\u5ea6: \u91ab\u5b78\u7cfb\u7db2\uf937\u6559\u5b78\u8a55\uf97e \u512a\uf97c\u6559\u5e2b\u734e\uf9fa<br \/>\n110\u5b78\u5e74\u5ea6: \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u751f\u547d\u79d1\u5b78\u9662\u7b2c\u4e8c\u5b63\u91cd\u8981\u671f\u520a\u8ad6\u6587<br \/>\n109\u5b78\u5e74\u5ea6: \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u751f\u547d\u79d1\u5b78\u9662\u7b2c\u4e8c\u5b63\u91cd\u8981\u671f\u520a\u8ad6\u6587<br \/>\n108\u5b78\u5e74\u5ea6: \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u7cfb\u826f\u5e2b\u76ca\u53cb<br \/>\n105-109\u5b78\uf98e\u5ea6: \u91ab\u5b78\u7cfb\u7db2\uf937\u6559\u5b78\u8a55\uf97e \u512a\uf97c\u6559\u5e2b\u734e\uf9fa<br \/>\n103\u5b78\uf98e\ufa01: \u91ab\u5b78\u7cfb\u7db2\uf937\u6559\u5b78\u8a55\uf97e \u512a\uf97c\u6559\u5e2b\u7409\u7483\u734e\u5ea7<br \/>\n102\u5b78\uf98e\ufa01: \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u826f\u5e2b\u76ca\u53cb\u5c0e\u5e2b\u734e<br \/>\n101-102\u5b78\uf98e\ufa01: \u91ab\u5b78\u7cfb\u7db2\uf937\u6559\u5b78\u8a55\uf97e \u512a\uf97c\u6559\u5e2b\u734e\uf9fa<\/p>\n<h2><strong>Conference Chair \/ Organizer<\/strong><\/h2>\n<p>The 27th International Workshop on Kaposi\u2019s Sarcoma Herpesvirus and Related Agents (2025\/06\/29-20255\/07\/02; California, USA) \u7814\u8a0e\u6703\u4e3b\u6301\u4eba<\/p>\n<h2><strong>Invited International Talks<\/strong><\/h2>\n<p>University of Pittsburg Medical Center (Aug. 2022)<br \/>\n\u53c3\u8a2a 2008 \u5e74\u75c5\u6bd2\u5b78\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b Harald zur Hausen \u5be6\u9a57\u5ba4 (Jul. 2017)<br \/>\nSeminar serious of USC School of Pharmacy (Feb. 2015)<br \/>\nInternational Conference on Infectious Diseases and Cancer (Oct. 2014)<br \/>\nThe 10th UCSD-UST NYMU-NCTU (Nov. 2016)<br \/>\nThe 8th UCSD-UST NYMU-NCTU (Nov. 2014)<\/p>\n<\/div>\n<div id=\"tab_publications-and-research-projects\" class=\"panel entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-publications-and-research-projects\">\n<h2 class=\"av-special-heading av-l86jf4-8ef8e1a5ca5ea53759a9f80b9760cc0f av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-22 el_before_av_hr avia-builder-el-first \"><strong>Publications<\/strong><\/h2>\n<div class=\"hr av-1ycm68-b967633e3dda36615505523e9efda219 hr-short avia-builder-el-23 el_after_av_heading el_before_av_textblock hr-left\">\n<p><strong><u>Virus-related Publications<\/u><\/strong><\/p>\n<ol>\n<li>S. Yang, D. Kim, S. Kang, C.J. Lai, I. Cha, <strong>P.C. Chang<\/strong>, J.U. Jung. Development of KSHV vaccine platforms and chimeric MHV68-K-K8.1 glycoprotein for evaluating the in vivo immunogenicity and efficacy of KSHV vaccine candidates. mBio 2024; e0291324.<\/li>\n<li>W. Yeh, Y.Q. Chen, W.S. Yang, Y.C. Hong, S. Kao, T.T. Liu, T.W. Chen, L. Chang, <strong>P.C. Chang*<\/strong>. SUMO modification of histone demethylase KDM4A in Kaposi\u2019s sarcoma-associated herpesvirus-induced primary effusion lymphoma. Journal of Virology 2022; 96(16):e0075522.<\/li>\n<li>S. Yang, W.W. Yeh, M. Campbell, L. Chang, <strong>P.C. Chang*<\/strong>. Long non-coding RNA KIKAT\/LINC01061 as a novel epigenetic regulator that relocates KDM4A on chromatin and modulates viral reactivation. PLoS Pathogens 2021; 17(6):e1009670.<\/li>\n<li>Campbell, W.S. Yang, W.W. Yeh, C.H. Kao, <strong>P.C.\u00a0Chang<\/strong>*. Epigenetic Regulation of Kaposi&#8217;s sarcoma-associated herpesvirus Latency. Frontiers in Microbiology 2020; 19(11):850.<\/li>\n<li>W. Liang, M.L. Wang, C.H. Chien, Y.P. Yang, A.A. Yarmishyn, W.Y. Lai, Y.H. Luo, Y.T. Lin, <strong>P.C. Chang*<\/strong>, S.H. Chiou*. Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection. Frontiers in Immunology 2020; 12(11):1022.<\/li>\n<li>S. Yang,\u00a0T.Y. Lin,\u00a0L. Chang, W.W.\u00a0Yeh, S.C.\u00a0Huang, T.Y.\u00a0Chen, Y.T.\u00a0Hsieh, S.T.\u00a0Chen, W.C.\u00a0Li,\u00a0C.C. Pan, M.\u00a0Campbell, C.H.\u00a0Yen, Y.A.\u00a0Chen, <strong>P.C.\u00a0Chang<\/strong><strong>*<\/strong>. HIV-1 Tat Interacts with a Kaposi&#8217;s Sarcoma-Associated Herpesvirus Reactivation-Upregulated Antiangiogenic Long Noncoding RNA, LINC00313, and Antagonizes Its Function. <strong>Journal of Virology<\/strong> 2020; 94(3):e01280-19.<\/li>\n<li>J. Lin, L.\u00a0Chang,\u00a0H.W. Chu,\u00a0H.J. Lin,\u00a0<strong>P.C. Chang<\/strong>,\u00a0R.Y.L. Wang,\u00a0B. Unnikrishnan, J.Y.\u00a0Mao,\u00a0S.Y. Chen,\u00a0C.C. Huang. High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots. Small 2019; 15(41):e1902641.<\/li>\n<li>S. Yang, M. Campbell, H.J. Kung,<strong> P.C. Chang*<\/strong>. In vitro SUMOylation Assay to Study SUMO E3 Ligase Activity. JoVE-Journal of Visualized Experiments 2018; 131(e56629):1-6.<\/li>\n<li>S. Yang, M. Campbell, <strong>P<\/strong><strong>.<\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong><strong>*<\/strong>. SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication. PLoS Pathogens 2017; 13(2):e1006216.<\/li>\n<li><strong>C. Chang*<\/strong>, M. Campbell, E.S. Robertson. Human Oncogenic Herpesvirus and Post-translational Modifications \u2013 Phosphorylation and SUMOylation. Frontiers in Microbiology 2016; 7:962.<\/li>\n<li>S. Yang, H.W. Hsu, M. Campbell, C.Y. Cheng, <strong>P.C. Chang<\/strong><strong>*.<\/strong> K-bZIP mediated SUMO-2\/3 specific modification on the KSHV genome negatively regulates lytic gene expression and viral reactivation. PLoS Pathogens 2015; 11(7): e1005051.<\/li>\n<li><strong>C. Chang<\/strong><strong>*<\/strong> and H.J. Kung. SUMO and KSHV Replication. Cancers 2014; 6(4):1905-1924.<\/li>\n<li>M. Campbell, K.Y. Kim, <strong>P<\/strong><strong>.<\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong>, S. Huerta, B. Shevchenko, D.H. Wang, C. Izumiya, H.J. Kung, Y. A Lytic Viral Long Non-coding RNA Modulates the Function of a Latent Protein. Journal of Virology 2014; 88(3):1843~1848.<\/li>\n<li>Y. Cheng, C.H. Chu, H.W. Hsu, F.R. Hsu, C.Y. Tang, W.C. Wang, H.J. Kung, <strong>P.C. Chang<\/strong><strong>*.<\/strong> An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example. BMC genomics 2014; 15:S1.<\/li>\n<li><strong>C. Chang<\/strong><strong>*<\/strong>, C.Y. Cheng, M. Campbell, Y.C. Yang, H.W. Hsu, T.Y. Chang, C.H. Chu, Y.W. Lee, C.L. Hung, S.M. Lai, C.G. Tepper, W.P. Hsieh, H.W. Wang, C.Y. Tang, W.C. Wang, H.J. Kung. The chromatin modification by SUMO-2\/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi&#8217;s sarcoma associated herpesvirus reactivation. BMC Genomics 2013; 14(1):824.<\/li>\n<li>M. Campbell, <strong>P<\/strong><strong>.<\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong>, S. Huerta, C. Izumiya, R. Davis, C.G. Tepper, K.Y. Kim, B. Shevchenko, D.H. Wang, J.U. Jung, P.A. Luciw, H.J. Kung, Y. Izumiya. Protein Arginine Methyltransferase 1-directed Methylation of Kaposi Sarcoma-associated Herpesvirus Latency-associated Nuclear Antigen. Journal of Biological Chemistry 2012; 287(8):5806\u2013<\/li>\n<li><strong>P<\/strong><strong>.<\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong><strong>*<\/strong>, Y. Izumiya, C.Y. Wu, L.D. Fitzgerald, M. Campbell, T. Ellison, K.S. Lam, P.A. Luciw, H.J. Kung. Histone demethylase JMJD2A regulates Kaposi&#8217;s sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor. Journal of Virology 2011; 85(7):3283-3293.<\/li>\n<li><strong>P<\/strong><strong>.<\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong><strong>*<\/strong>, L.D. Fitzgerald, D.A. Hsia, Y. Izumiya, C.Y. Wu, W.P. Hsieh, S.F. Lin, M. Campbell, K.S. Lam, P.A. Luciw, C.G. Tepper, H.J. Kaposi&#8217;s sarcoma associated herpesvirus (KSHV) encodes a SUMO E3 ligase which is SIM-dependent and SUMO-2\/3-specific. Journal of Biological Chemistry 2010; 285(8):5266-5273.<\/li>\n<li><strong>P<\/strong><strong>.<\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong><strong>*<\/strong>, L. Fitzgerald, A. Van Geelen, Y. Izumiya, T.J. Ellison, D.H. Wang, D.K. Ann, P.A. Luciw, H.J. Kung. KRAB domain-associated protein-1 as a latency regulator for Kaposi\u2019s sarcoma-associated herpesvirus and its modulation by the viral protein kinase. Cancer Research 2009; 69(14):5681-5689.<\/li>\n<li>Y.L. Lin, <strong>P<\/strong><strong>.<\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong>, Y. Wang, and M. Li. Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169. Virus Research 2008; 131(2):213-223.<\/li>\n<li><strong>P<\/strong><strong>. <\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong><strong>*<\/strong> and M. Li. Kaposi&#8217;s sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor. Journal of Virology 2008; 82(1):278-290.<\/li>\n<li><strong>P<\/strong><strong>. <\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong><strong>*<\/strong>, C.W. Chi, G.Y. Chau, F.Y. Li, Y.H. Tsai, J.C. Wu and Y.H.W. DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus associated hepatocellular carcinoma and is involved in cell growth control. Oncogene 2006; 25(14):1991-2003.<\/li>\n<\/ol>\n<p><strong><u>Cancer-related Publications<\/u><\/strong><\/p>\n<ol>\n<li>A. Chen, <strong>P. C. Chang*<\/strong>, W.W. Yeh, T.Y. Hu, Y.C. Hong, Y.C. Wang, W.J. Huang, T.P. Lin. The lncRNA TPT1-AS1 promotes the survival of neuroendocrine prostate cancer cells by facilitating autophagy. American Journal of Cancer Research 2024 May 15;14(5):2103-2123.<\/li>\n<li>C. Hong, T.Y. Hu, C.S. Hsu, W.W. Yeh, W.Z. Wong, T.W. Shen, C.H. Chang, K. Hua, C.Y. Tung, Y.C. Peng, C.C., W.J. Huang, <strong>P.C. Chang<\/strong><strong>, <\/strong>T.P. Lin. Single-cell analysis of castration-resistant prostate cancers to identify potential biomarkers for diagnosis and prognosis of neuroendocrine prostate cancer. American Journal of Cancer Research 2023 Oct 15;13(10):4560-4578.<\/li>\n<li>H. Chang, T.Y. Cheng, W.W. Yeh, Y.L. Luo, M. Campbell, T.C. Kuo, T.W. Shen, Y.C. Hong, C.H. Tsai, Y.C. Peng, C.C. Pan, M.H. Yang, J.C. Shih, H.J. Kung, W.J. Huang, <strong>P.C. Chang<\/strong><strong>*<\/strong><strong>, <\/strong>T.P. Lin. REST-repressed lncRNA LINC01801 induces neuroendocrine differentiation in prostate cancer via transcriptional activation of autophagy. American Journal of Cancer Research 2023 Sep 15;13(9):3983-4002.<\/li>\n<li>T. Chang, T.P. Lin, J.T. Tang, M. Campbell, Y.L. Luo, S.Y. Lu, C.P. Yang, T.Y. Cheng, C.H. Chang, T.T. Liu, C.H. Lin, H.J. Kung, C.C. Pan, <strong>P.C. Chang<\/strong><strong>*<\/strong>. HOTAIR is a REST-regulated LncRNA that Promotes Neuroendocrine Differentiation in Castration Resistant Prostate Cancer. Cancer Letters 2018; 433:43-52.<\/li>\n<li>C. Lin, Y.T. Chang, M. Campbell, H.C. Lee, J. C. Shih, <strong>P.C. Chang<\/strong><strong>*<\/strong>. MAOA- a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells. Scientific Reports 2017; 7:46338.<\/li>\n<li>T. Chang, T.P Lin, M. Campbell, C.C. Pan, S.H. Lee, H.C. Lee, M.H. Yang, H.J. Kung, <strong>P.C. Chang<\/strong><strong>*<\/strong><strong>. <\/strong>REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer. Scientific Reports 2017; 3(7):42795.<\/li>\n<li>P. Lin, Y.T. Chang, S.Y. Lee, M. Campbell, T.C. Wang, S.H. Shen, H.J. Chung, Y.H. Chang, Allen W Chiu, C.C. Pan, C.H. Lin, C.Y. Chu, H.J. Kung, C.Y. Cheng, <strong>P.C. Chang<\/strong><strong>*<\/strong>. REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling. Oncotarget 2016; 7:26137~26151.<\/li>\n<li><strong>C. Chang<\/strong><strong>*<\/strong>, T.Y. Wang, Y.T. Chang, C.Y. Chu, C.L. Lee, H.W. Hsu, T.A. Zhou, Z. Wu, R.H. Kim, S.J. Desai, S. Liu, H.J. Kung. Autophagy Pathway Is Required for IL-6 Induced Neuroendocrine Differentiation and Chemoresistance of Prostate Cancer LNCaP Cells. <strong>PLoS ONE<\/strong> 2014; 9:e88556.<\/li>\n<li>Z. Wu, <strong>P<\/strong><strong>.<\/strong><strong>C<\/strong><strong>.<\/strong><strong> Chang<\/strong>, J. Yang, C.Y. Chu, L.Y. Wang, N.T. Chen, A.H. Ma, S.J. Desai, S.H. Lo, C.P. Evans, K.S. Lam, and H.J. Kung. Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors. Genes &amp; Cancer 2010; 1(1):40-49.<\/li>\n<\/ol>\n<p><strong><u>Other Publications<\/u><\/strong><\/p>\n<ol>\n<li>P. Tsao, F.Y. Tseng, C.W. Chao, M.H. Chen, Y.C. Yeh, B.O. Abdulkareem, S.Y. Chen, W.T. Chuang,\u00a0<strong>P.C. Chang<\/strong>, I.C. Chen, P.H. Wang, C.S. Wu, C.Y. Tsai, S.T. Chen. NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression. Journal of Clinical Investigation 2023;133(3):e157272.<\/li>\n<li>T. Hsieh, T.L. Tsai, S.Y. Huang, J.W. Heng, Y.C. Huang, P.Y. Tsai, C.C. Tu, T.L. Chao, Y.M. Tsai,\u00a0<strong>P.C. Chang<\/strong>, C.K. Lee, G.Y. Yu, S.Y. Chang, I.L. Dzhagalov, C.L. Hsu. IFN-stimulated metabolite transporter ENT3 facilitates viral genome release. EMBO Reports 2023; 24(3):e55286.<\/li>\n<li>C. Tsai, W.H. Chiang, C.H. Wu, Y.C. Li, M. Campbell, P.H. Huang, M.W. Lin, C.H. Lin, S.M. Cheng, <strong>P.C.\u00a0Chang<\/strong><strong>*<\/strong>, C.C. Cheng. miR-548aq-3p is a novel target of Far infrared radiation which predicts coronary artery disease endothelial colony forming cell responsiveness. Scientific Reports 2020; 10(1):6805.<\/li>\n<li>P. Yang, W.S.\u00a0Yang, Y.H.\u00a0Wong, K.H.\u00a0Wang, Y.C.\u00a0Teng, M.H.\u00a0Chang, K.H.\u00a0Liao, F.S.\u00a0Nian, C.C.\u00a0Chao, JW\u00a0Tsai, W.L.\u00a0Hwang, M.W.\u00a0Lin, T.Y.\u00a0Tzeng, P.N.\u00a0Wang, M.\u00a0Campbell, L.K.\u00a0Chen, T.F.\u00a0Tsai, <strong>P.C.\u00a0Chang<\/strong><strong>*<\/strong>, H.J.\u00a0Kung. Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. Aging Cell 2020; 19(5):e13107.<\/li>\n<li>Kant, C.H. Yen, J.H. Hung, C.K. Lu, C.Y. Tung,<strong> P.C. Chang<\/strong>, Y.H. Chen, Y.C. Tyan, Y.A. Chen. Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma. Scientific Reports 2019; 9(1):1968.<\/li>\n<li>H. Liu, J.W. Tsai, J.L. Chen, W.S. Yang, <strong>P.C. Chang<\/strong>, P.L. Cheng, D.L. Turner, Y. Yanagawa, T.W. Wang, J.Y. Yu. Ascl1 promotes tangential migration and confines migratory routes by induction of Ephb2 in the telencephalon. Scientific Reports 2017; 7(42895):1.<\/li>\n<li>F. Chiou, <strong>P.C. Chang<\/strong>, C.I. Chou, C.F. Chen. Protein constituent contributes to the hypotensive and vasorelaxant activities of <em>Cordyceps Sinensis<\/em>. Life Sciences 2000; 66(14):1369-1376.<\/li>\n<\/ol>\n<\/div>\n<section class=\"av_textblock_section av-hnzwvk-10ffa767538f43a722ceaaccc0c6e919\">\n<div class=\"avia_textblock\"><\/div>\n<\/section>\n<div class=\"av-special-heading av-kznhx2qs-e11d2066d27099926dbee1f2a5a6bb3b av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-25 el_after_av_textblock el_before_av_textblock \">\n<h2 class=\"av-special-heading-tag\"><strong>Research Projects<\/strong><\/h2>\n<\/div>\n<section class=\"av_textblock_section av-kznhwcjk-cbd8a23f555c3a2b9eeb88a5f3f6efe0\">\n<div class=\"avia_textblock av_inherit_color\">\n<ol>\n<li>Characterization of TWEAK as a novel circulating aging factor [TWEAK\u6210\u70ba\u5faa\u74b0\u8001\u5316\u56e0\u5b50\u4e4b\u7279\u6027\u7814\u7a76]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 2023\/08\/01-2026\/07\/31, National Science and Technology Council (NSTC) (112-2314-B-A49 -023 -MY3; 3 years)<\/span><\/li>\n<\/ol>\n<ol start=\"2\">\n<li>Study the SUMOylation of histone demethylase KDM4A in the pathogenesis and treatment of KSHV-associated primary effusion lymphoma (PEL) [\u63a2\u8a0e SUMO \u4fee\u98fe\u7d44\u7e54\u86cb\u767d\u53bb\u7532\u57fa\u9176KDM4A \u5c0d\u5361\u6ce2\u897f\u8089\u7624\u76f8\u95dc\u6027\u76b0\u75b9\u75c5\u6bd2\u611f\u67d3\u6240\u5f15\u767c\u7684\u539f\u767c\u6027\u7a4d\u6db2\u6dcb\u5df4\u7624\u4e4b\u81f4\u75c5\u6a5f\u5236\u8207\u6cbb\u7642\u6f5b\u529b]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 2022\/08\/01-2025\/07\/31, National Science and Technology Council (NSTC) (111-2320-B-A49 -030 -MY3; 3 years)<\/span><\/li>\n<\/ol>\n<ol start=\"3\">\n<li>Investigation of the mechanism and medical implications of a novel histone lysine demethylase KDM4A interacting long non-coding RNAs (LncRNAs) LINC01061 in viral reactivation and tumorigenesis [\u63a2\u8a0e\u7d44\u86cb\u767d\u53bb\u7532\u57fa\u9176 KDM4A \u7d50\u5408\u9577\u93c8\u975e\u7de8\u78bcRNA (lncRNAs) LINC01061 \u53c3\u8207\u75c5\u6bd2\u6d3b\u5316\u8207\u7d30\u80de\u764c\u5316\u7684\u6a5f\u5236\u53ca\u5176\u91ab\u7642\u89d2\u8272(111-113)]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 2022\/01\/01-2024\/12\/31, National Health Research Institutes (NHRI-EX111-11125BI; 3 years)<\/span><\/li>\n<\/ol>\n<ol start=\"4\">\n<li>Epigenetic regulation of IL-10 production in virus induced B-lymphocyte in modulation host inflammatory response and cell pathogenesis[\u63a2\u8a0e\u75c5\u6bd2\u8a98\u767cB\u6dcb\u5df4\u7d30\u80de\u751f\u6210IL-10\u4e4b\u8868\u95dc\u57fa\u56e0\u9ad4\u8abf\u63a7\u53ca\u8abf\u7bc0\u5bbf\u4e3b\u7d30\u80de\u4e4b\u767c\u708e\u53cd\u61c9(1\/2~2\/2)]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 202107-201312, Ministry of Science and Technology (MOST) (109-2926-I-010-503 -, 111-2926-I-010-502-G; 2 years) &#8212; \u8207CCF\u5408\u4f5c\u8a08\u756b<\/span><\/li>\n<\/ol>\n<ol start=\"5\">\n<li>Using KSHV reactivation as a model to identify oncogenic long non-coding RNAs (LncRNAs) and elucidate their role in epigenetic regulation of human cancer [\u5229\u7528\u81f4\u764c\u6027\u5361\u6ce2\u6c0f\u8089\u7624\u76f8\u95dc\u6027\u76b0\u75b9\u75c5\u6bd2\u7576\u7814\u7a76\u6a21\u5f0f\u5c0b\u627e\u764c\u5316\u76f8\u95dc\u4e4b\u9577\u93c8\u975e\u7de8\u78bcRNA\u4e26\u63a2\u8a0e\u5176\u5728\u8868\u89c0\u907a\u50b3\u6027\u816b\u7624\u767c\u751f\u904e\u7a0b\u4e2d\u6240\u626e\u6f14\u7684\u89d2\u8272]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 2019\/08\/01-2022\/07\/31, Ministry of Science and Technology (MOST) (108-2320-B-010-029-MY3; 3 years)<\/span><\/li>\n<\/ol>\n<ol start=\"6\">\n<li>Using KSHV as a model to study the role of SUMOylation in regulating the chromatin remodeling mediated transcription regulation and oncogenic characteristic of JMJD2A [\u5229\u7528\u5361\u6ce2\u897f\u8089\u7624\u76f8\u95dc\u6027\u76b0\u75b9\u75c5\u6bd2\u7576\u4f5c\u5be6\u9a57\u6a21\u5f0f:\u63a2\u8a0eSUMO\u4fee\u98fe\u7d44\u7e54\u86cb\u767d\u53bb\u7532\u57fa\u9176JMJD2A\u5c0d\u5176\u9644\u57fa\u56e0\u9ad4\u8abf\u63a7\u57fa\u56e0\u8868\u73fe\u8207\u7d30\u80de\u764c\u5316\u80fd\u529b\u4e4b\u5f71\u97ff]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 20160801-20190731, Ministry of Science and Technology (MOST) (105-2320-B-010-007-MY3; 3 years)<\/span><\/li>\n<\/ol>\n<ol start=\"7\">\n<li>The role of REST in epigenetic regulation of neuroendocrine cancer stem cell-mediated chemoresistence [REST\u6240\u8abf\u63a7\u4e4b\u9644\u57fa\u56e0\u9ad4\u8f49\u5316\u5c0d\u795e\u7d93\u5167\u5206\u6ccc\u5206\u5316\u764c\u75c7\u5e79\u7d30\u80de\u5c0e\u81f4\u4e4b\u651d\u8b77\u817a\u764c\u5316\u7642\u6a5f\u5236\u4e4b\u7814\u7a76]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 20150801-20160731, Ministry of Science and Technology (MOST) (104-2320-B-010-038-; 1 year)<\/span><\/li>\n<\/ol>\n<ol start=\"8\">\n<li>MAOA mediates REST action on neuroendocrine differentiation and autophagy activation of prostate cancer relapse[MAOA \u5728\u5fa9\u767c\u578b\u651d\u8b77\u817a\u764c\u4e2dREST\u9020\u6210\u4e4b\u764c\u7d30\u80de\u795e\u7d93\u5167\u5206\u6ccc\u6a23\u5206\u5316\u8207\u81ea\u566c\u6a5f\u5236\u6d3b\u5316\u4e2d\u6240\u626e\u6f14\u7684\u89d2\u8272(1\/2~2\/2)]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 20140901 ~20170331, Ministry of Science and Technology (MOST) (103-2911-I-010-515 -, 104-2911-I-010-505 ; 2 years) &#8212; \u8207USC\u5408\u4f5c\u8a08\u756b<\/span><\/li>\n<\/ol>\n<ol start=\"9\">\n<li>SUMO and KSHV: Epigenetic regulation of Oncogenic Herpesvirus[SUMO\u8207\u5361\u6ce2\u897f\u8089\u7624\u76f8\u95dc\u76b0\u75b9\u75c5\u6bd2:\u9644\u57fa\u91d1\u9ad4\u8abf\u63a7\u81f4\u764c\u6027\u75c5\u6bd2\u76b0\u75b9(102-105)]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 20130101-20161231, National Health Research Institutes (NHRI-EX105-10215BC; 4 years)<\/span><\/li>\n<\/ol>\n<ol start=\"10\">\n<li>The role of SUMO-2\/3 in epigenetic regulation of herpesvirus: Implication in developing novel SUMO-2\/3 target therapy [\u9644\u57fa\u56e0\u9ad4\u6a21\u5f0f\u63a2\u5f0fSUMO-2\/3 \u8abf\u63a7\u75b1\u75b9\u75c5\u6bd2\u7684\u751f\u9577\u8207\u81f4\u75c5\u6a5f\u5236:\u767c\u5c55SUMO-2\/3\u5c08\u4e00\u6027\u6a19\u9776\u85e5\u7269(1\/3~3\/3)]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 20120801~20150731, National Science Council (NSC) (101-2321-B-010-017-; 102-2321-B-010-015-; 103-2321-B-010-006-; 3 years)<\/span><\/li>\n<\/ol>\n<ol start=\"11\">\n<li>Autophagy, neuroendocrine differentiation and prostate cancer therapeutic resistance [\u7d30\u80de\u81ea\u566c\u6a5f\u5236\u5728\u795e\u7d93\u5167\u5206\u6ccc\u5206\u5316\u5c0e\u81f4\u4e4b\u6297\u651d\u8b77\u817a\u764c\u6cbb\u7642\u4f5c\u7528\u4e4b\u63a2\u8a0e]\n<strong style=\"color: #555555;\">PI<\/strong><span style=\"color: #555555;\">, 20120801~20150731, National Science Council (NSC) (101-2320-B-010-047-MY3; 3 years).<\/span><\/li>\n<\/ol>\n<\/div>\n<\/section>\n<\/div>\n<div id=\"tab_laboratory-overview\" class=\"panel entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-laboratory-overview\">\n<div class=\"av-special-heading av-kznibasw-ab1d390a1c059ac2d896fbe42b8508d0 av-special-heading-h2 avia-builder-el-30 el_before_av_textblock avia-builder-el-first \">\n<h2><strong>Research Focus<\/strong><\/h2>\n<\/div>\n<section class=\"av_textblock_section av-5f354g-c71313f9179911d4d101270c7a819aed\">\n<div class=\"avia_textblock\"><\/div>\n<\/section>\n<section class=\"av_textblock_section av-loz2feyo-296e968d96159ae031e9c61be4482228\">\n<div class=\"avia_textblock\">\n<p><strong>(I) Virus-Host interaction: Epigenetic regulation of herpesvirus oncogenesis<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-554\" src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001.jpg\" alt=\"Virus-Host interaction\" width=\"1471\" height=\"1036\" srcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001.jpg 1471w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-300x211.jpg 300w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1024x721.jpg 1024w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-768x541.jpg 768w\" sizes=\"auto, (max-width: 1471px) 100vw, 1471px\" \/><\/p>\n<p>\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u4e3b\u8981\u5206\u70ba\u4e09\u5927\u985e:<\/p>\n<p>(1) DNA\u7532\u57fa\u5316; (2)\u7d44\u86cb\u767d\u7532\u57fa\u5316; (3)\u9577\u93c8\u975e\u7de8\u78bcRNA\u3002<\/p>\n<p>\u6211\u5011\u4ee5\u81f4\u764c\u76b0\u75b9\u75c5\u6bd2KSHV\u4f5c\u70ba\u7814\u7a76\u6a21\u578b\uff0c\u63a2\u8a0e\u7b2c\u4e00\u500b\u88ab\u767c\u73fe\u80fd\u79fb\u9664\u7d44\u86cb\u767d\u4e09\u7532\u57fa\u7684\u53bb\u7532\u57fa\u9176KDM4A\/JMJD2A\u5728\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u8207\u816b\u7624\u5f62\u6210\u4e2d\u7684\u89d2\u8272\u3002\u7814\u7a76\u767c\u73fe\uff0cKDM4A\u80fd\u8b93\u67d3\u8272\u8cea\u7dad\u6301\u4f4e\u7684\u57fa\u56e0\u6291\u5236\u6a19\u8a8c3K9me3\uff0c\u8b93\u57fa\u56e0\u5728\u53d7\u5230\u523a\u6fc0\u6642\u53ef\u4ee5\u5feb\u901f\u555f\u52d5\u3002\u9032\u4e00\u6b65\u767c\u73fe\uff0cKSHV\u7684\u75c5\u6bd2\u86cb\u767dK-bZIP\uff0c\u662fSUMO E3\u9023\u63a5\u9176\uff0c\u4ed6\u6703\u5c0d KDM4A\u9032\u884cSUMO\u4fee\u98fe\u3002\u9019\u500b\u4fee\u98fe\u5c0d KDM4A \u7d50\u5408\u67d3\u8272\u8cea\u4e26\u767c\u63ee\u53bb\u7532\u57fa\u5316\u81f3\u95dc\u91cd\u8981\u3002\u66f4\u6709\u8da3\u7684\u662f\uff0c\u6211\u5011\u767c\u73feKSHV \u4e5f\u6703\u8a98\u5c0eKIKAT\u65b0\u578b\u9577\u93c8\u975e\u7de8\u78bcRNA (lncRNA) \u8868\u73fe\uff0cKIKAT\u80fd\u5f15\u5c0eKDM4A\u5f80\u555f\u52d5\u5b50\u5340\u57df\u4e0a\u6e38\u79fb\u52d5\uff0c\u96e2\u958b\u8f49\u9304\u8d77\u59cb\u4f4d\u9ede (TSS)\uff0c\u4e26\u5f62\u6210\u4e00\u500b\u300c\u9694\u96e2\u5668\u300d\uff0c\u963b\u64cbH3K9me3\u5165\u4fb5\uff0c\u78ba\u4fdd\u57fa\u56e0\u80fd\u5feb\u901f\u555f\u52d5\u3002\u6b64\u5916\uff0c\u6211\u5011\u5229\u7528single-cell RNA-seq\u8207bulk RNA-seq\u8b49\u5be6\uff0cKDM4A\u5c0dKSHV\u5728\u88c2\u89e3\u671f\u7684\u75c5\u6bd2\u57fa\u56e0\u8868\u9054\u8207\u75c5\u6bd2\u7522\u751f\u81f3\u95dc\u91cd\u8981\uff0c\u4e26\u4e14\u80fd\u4fc3\u9032\u611f\u67d3\u7d30\u80de\u7684\u5b58\u6d3b\u3001\u79fb\u52d5\u548c\u8840\u7ba1\u65b0\u751f\uff0c\u70ba\u75c5\u6bd2\u63d0\u4f9b\u5145\u8db3\u990a\u5206\u3002<\/p>\n<p>\u7c21\u55ae\u4f86\u8aaa\uff0c\u75c5\u6bd2\u4e0d\u53ea\u80fd\u8b93\u81ea\u5df1\u5728\u9700\u8981\u6642\u5feb\u901f\u518d\u6d3b\u5316\u4e26\u5927\u91cf\u8907\u88fd\uff0c\u9084\u6703\u5229\u7528\u9ad8\u8d85\u7684\u8868\u89c0\u907a\u50b3\u624b\u6cd5\u6539\u9020\u7d30\u80de\u67d3\u8272\u8cea\u74b0\u5883\uff0c\u300c\u8eb2\u907f\u300d\u514d\u75ab\u7cfb\u7d71\u4ee5\u53ca\u5c0e\u81f4\u764c\u75c7\u5f62\u6210\u3002\u56e0\u6b64\uff0c\u5982\u679c\u80fd\u963b\u65b7KDM4A\u7684\u529f\u80fd\uff0c\u5c31\u6709\u6a5f\u6703\u6e05\u9664\u611f\u67d3\u7d30\u80de\u3001\u6291\u5236\u764c\u7d30\u80de\u64f4\u6563\uff0c\u4e14\u6e1b\u5c11\u75c5\u6bd2\u91cf\u3002\u76ee\u524d\uff0c\u6211\u5011\u6b63\u5728\u6df1\u5165\u63a2\u7d22KDM4A\u5728\u4e0d\u540c\u75c5\u6bd2\u8207\u764c\u75c7\u4e2d\u7684\u89d2\u8272\uff0c\u4e26\u767c\u5c55\u4ee5\u963b\u65b7KDM4A\u53ca\u5176SUMO\u4fee\u98fe\u70ba\u6838\u5fc3\u7684\u5168\u65b0\u6297\u75c5\u6bd2\u81f4\u764c\u6cbb\u7642\u7b56\u7565\u3002<\/p>\n<p><strong>\u00a0(II) Tumor-Immune Interplay in HBV-Associated HCC<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-553\" src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image003.png\" alt=\"Tumor-Immune Interplay in HBV-Associated HCC\" width=\"1156\" height=\"1125\" srcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image003.png 1156w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image003-300x292.png 300w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image003-1024x997.png 1024w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image003-768x747.png 768w\" sizes=\"auto, (max-width: 1156px) 100vw, 1156px\" \/><\/p>\n<p>\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291 (ICI) \u900f\u904e\u6062\u5fa9\u514d\u75ab\u529b\uff0c\u91cd\u5851\u764c\u75c7\u6cbb\u7642\uff0c\u4f46\u5176\u6548\u679c\u5e38\u53d7T\u7d30\u80de\u8870\u7aed\u9650\u5236\u3002\u6700\u65b0\u7814\u7a76\u767c\u73fe\uff0cT\u7d30\u80de\u53ef\u80fd\u9032\u5165\u4e00\u7a2e\u5e79\u7d30\u80de\u72c0\u614b\uff0c\u7dad\u6301T\u7d30\u80de\u529f\u80fd\uff0c\u5ef6\u7e8c\u514d\u75ab\u6548\u80fd\u3002\u75c5\u6bd2\u76f8\u95dc\u809d\u7d30\u80de\u764c (HCC) \u5c0dICI\u7684\u53cd\u61c9\u512a\u65bc\u975e\u75c5\u6bd2\u6027HCC\uff0c\u56e0\u6b64\u6211\u5011\u6b63\u63a2\u8a0eHBV\u76f8\u95dcHCC\u4e2d\u662f\u5426\u5b58\u5728\u5177\u6709\u5e79\u7d30\u80de\u7279\u6027\u4e4bT\u7d30\u80de\uff0c\u4e26\u8a55\u4f30\u5176\u4f5c\u70ba\u514d\u75ab\u7642\u6cd5\u65b0\u6a19\u9776\u7684\u6f5b\u529b\u3002<\/p>\n<p><strong>(III) Epigenetic regulation of lineage plasticity in prostate cancer progression<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-552\" src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image005.png\" alt=\"Epigenetic regulation of lineage plasticity in prostate cancer progression\" width=\"1524\" height=\"1132\" srcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image005.png 1524w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image005-300x223.png 300w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image005-1024x761.png 1024w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image005-768x570.png 768w\" sizes=\"auto, (max-width: 1524px) 100vw, 1524px\" \/><\/p>\n<p>\u8868\u89c0\u907a\u50b3\u6a5f\u5236\u6703\u8abf\u63a7\u7d30\u80de\u53ef\u5851\u6027\uff0c\u80fd\u4f7f\u76f8\u540c\u57fa\u56e0\u578b\u5728\u74b0\u5883\u523a\u6fc0\u4e0b\u7522\u751f\u7d30\u80de\u591a\u6a23\u6027\uff0c\u4e26\u6210\u70ba\u6cbb\u7642\u6297\u6027\u7684\u95dc\u9375\u56e0\u7d20\u3002\u6211\u5011\u7684\u7814\u7a76\u767c\u73fe\u96c4\u6fc0\u7d20\u525d\u596a\u3001IL-6 \u53ca\u7f3a\u6c27\u53ef\u8a98\u5c0e\u651d\u8b77\u817a\u764c\u8d70\u5411\u795e\u7d93\u5167\u5206\u6ccc\u5206\u5316\u3002\u900f\u904eRNA-seq\u8207ChIP-seq\u5206\u6790\uff0c\u6211\u5011\u9451\u5b9a\u51fa\u591a\u500b\u8207NEPC \u767c\u5c55\u76f8\u95dc\u7684\u7de8\u78bc\u8207\u975e\u7de8\u78bc\u57fa\u56e0\uff0c\u7d93\u7531\u6d3b\u5316\u81ea\u566c\u9014\u5f91\u4fc3\u9032\u816b\u7624\u7d30\u80de\u5206\u5316\u8207\u5b58\u6d3b\u3002\u900f\u904esingle-cell RNA-seq\u5206\u6790\uff0c\u63ed\u793aNEPC\u5177\u6709\u4e0d\u540c\u4e9e\u7fa4\uff0c\u4e14\u767c\u73feREST\u8207N-MYC\u662f\u8abf\u63a7NEPC\u9032\u5165\u4e0d\u540c\u4e9e\u7fa4\u7684\u95dc\u9375\u8868\u89c0\u63a7\u56e0\u5b50\u3002\u9019\u4e9b\u767c\u73fe\u4e0d\u50c5\u52a0\u6df1\u6211\u5011\u5c0d\u81f4\u6b7b\u6027\u651d\u8b77\u817a\u764c\u7684\u7406\u89e3\uff0c\u4e5f\u70ba\u500b\u4eba\u5316\u7cbe\u6e96\u91ab\u7642\u63d0\u4f9b\u4e86\u65b0\u5951\u6a5f\u3002<\/p>\n<p><strong>(IV) Tumor microenvironment in head and neck cancer progression<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-555\" src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image006.jpg\" alt=\"Tumor microenvironment in head and neck cancer progression\" width=\"1473\" height=\"1061\" srcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image006.jpg 1473w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image006-300x216.jpg 300w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image006-1024x738.jpg 1024w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image006-768x553.jpg 768w\" sizes=\"auto, (max-width: 1473px) 100vw, 1473px\" \/><\/p>\n<p>\u767c\u708e\u8207\u6297\u767c\u708e\u578b\u5de8\u566c\u7d30\u80de\u6240\u5851\u9020\u7684\u5fae\u74b0\u5883\uff0c\u4e0d\u50c5\u53c3\u8207\u5bbf\u4e3b\u9632\u79a6\uff0c\u4e5f\u4fc3\u9032\u764c\u75c7\u7684\u767c\u5c55\u3002\u6211\u5011\u767c\u73fe\uff0c\u764c\u75c7\u5e79\u7d30\u80de (CSCs)\u6703\u8a98\u5c0e M1 \u5de8\u566c\u7d30\u80de\u7522\u751f\u8207\u795e\u7d93\u5167\u5206\u6ccc\u5206\u5316\u76f8\u95dc\u7684\u7d30\u80de\u6fc0\u7d20\u3002\u7d50\u5408\u8f49\u9304\u9ad4\u8207\u8cea\u8b5c\u5206\u6790\uff0c\u767c\u73fe\u91a3\u89e3\u4f5c\u7528\u5c0d\u65bc\u76f8\u95dc\u7d30\u80de\u6fc0\u7d20\u7684\u7522\u751f\u6709\u91cd\u8981\u8ca2\u737b\u3002\u56e0\u6b64\uff0cCSC\u8a98\u5c0e\u7684 M1\u5de8\u566c\u7d30\u80de\u6703\u4f7f\u764c\u7d30\u80de\u8d70\u5411\u6cbb\u7642\u6297\u6027\u795e\u7d93\u5167\u5206\u6ccc\u5206\u5316\u764c\u3002\u9019\u4e9b\u767c\u73fe\u63d0\u4f9b\u4e86\u4f7f\u7528\u514d\u75ab\u7642\u6cd5\u4f86\u963b\u6b62\u764c\u75c7\u66f4\u60e1\u6027\u7684\u6cbb\u7642\u6a5f\u6703\u3002<\/p>\n<p><strong>(V) Muscle-to-brain axis in aging<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-551\" src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image007.png\" alt=\"\" width=\"1409\" height=\"968\" srcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image007.png 1409w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image007-300x206.png 300w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image007-1024x704.png 1024w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image007-768x528.png 768w\" sizes=\"auto, (max-width: 1409px) 100vw, 1409px\" \/><\/p>\n<p>\u808c\u8089\u8cea\u91cf\u548c\u529b\u91cf\u7684\u55aa\u5931\uff0c\u7a31\u70ba\u808c\u5c11\u75c7\uff0c\u662f\u8001\u5e74\u4eba\u865b\u5f31\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u4e5f\u662f\u751f\u6d3b\u54c1\u8cea\u4e0b\u964d\u548c\u91ab\u7642\u652f\u51fa\u589e\u52a0\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u7136\u800c\uff0c\u5c0d\u65bc\u808c\u8089\u8cea\u91cf\u55aa\u5931\u8207\u795e\u7d93\u9000\u5316\u4e4b\u9593\u7684\u95dc\u806f\u5c1a\u4e0d\u6e05\u695a\u3002\u7d30\u80de\u5916\u56ca\u6ce1 (EVs)\uff0c\u4f8b\u5982\u5916\u6ccc\u9ad4\uff0c\u662f\u7531\u7d30\u80de\u91cb\u653e\u7684\u5c0f\u9846\u7c92\uff0c\u4ecb\u5c0e\u7d30\u80de\u9593\u7684\u901a\u8a0a\uff0c\u5c07\u7269\u8cea\u8f49\u79fb\u5230\u53d7\u9ad4\u7d30\u80de\u3002\u6211\u5011\u7684\u7814\u7a76\u767c\u73fe\uff0c\u4f86\u81ea\u840e\u7e2e\u808c\u8089\u7d30\u80de\u7684\u5916\u6ccc\u9ad4\uff0c\u53ef\u4ee5\u7d93\u7531\u8840\u6db2\u5c07\u5fae\u5c0fRNA\u8f49\u79fb\u5230\u795e\u7d93\u7d30\u80de\uff0c\u8abf\u63a7\u795e\u7d93\u7d30\u80de\u4e2d\u7684\u7de8\u78bc\u548c\u975e\u7de8\u78bcRNA\uff0c\u5c0e\u81f4\u795e\u7d93\u7d30\u80de\u529f\u80fd\u969c\u7919\u3002<\/p>\n<\/div>\n<\/section>\n<section class=\"av_textblock_section av-kznifv87-6f7174ad7b0e3055262386c069bdaca4\">\n<div class=\"avia_textblock\">\n<h2><strong>Laboratory Members<\/strong><\/h2>\n<p><strong>\u73fe\u5728\u6210\u54e1<\/strong><strong>:<\/strong><\/p>\n<p><strong>\u535a\u58eb\u751f<\/strong><strong>: <\/strong>\u6c88\u66c9\u6d25<\/p>\n<p><strong>\u78a9\u58eb\u751f<\/strong><strong>: <\/strong>\u9ec3\u5100\u7db8\u3001\u984f\u4e4b\u5bb8\u3001\u834a\u7fbd\u828a\u3001\u5433\u67cf\u6bc5<\/p>\n<p><strong>\u5927\u5b78\u90e8<\/strong><strong>: <\/strong>\u738b\u7d39\u4e1e\u3001\u694a\u777f\u5947\u3001\u738b\u742e\u8ce2<\/p>\n<p><strong>\u52a9\u7406<\/strong><strong>: <\/strong>\u8b1d\u8559\u5982\u3001\u9ec3\u74b5\u5e06<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u6b77\u5c46\u78a9\u58eb\u7562\u696d\u751f<\/strong><strong> (<\/strong><strong>\u5165\u5b78<\/strong><strong>):<\/strong><\/p>\n<p><strong>2011\/09 <\/strong><strong>\u5f35\u6021\u5a77<\/strong> (\u8ad6\u6587\u767c\u8868: PLoS One. 2014 Feb 14; 9(2):e88556)<\/p>\n<p><strong>2011\/09 <\/strong><strong>\u694a\u5955\u7a0b<\/strong> (\u8ad6\u6587\u767c\u8868: BMC Genomics. 2013 Nov 23; 14:824)<\/p>\n<p><strong>2013\/09 <\/strong><strong>\u694a\u5b9b\u73ca<\/strong> (\u8ad6\u6587\u767c\u8868: PLoS Pathogens. 2015 Jul 21; 11(7):e1005051)<\/p>\n<p><strong>2013\/09 <\/strong><strong>\u674e\u677e\u9060<\/strong> (\u8ad6\u6587\u767c\u8868: Oncotarget. 2016 May 3; 7(18):26137)<\/p>\n<p><strong>2015\/09 <\/strong><strong>\u7f85\u52fb\u91cc<\/strong><\/p>\n<p><strong>2015\/09 <\/strong><strong>\u9ec3\u8a69\u6674<\/strong><\/p>\n<p><strong>2016\/09 <\/strong><strong>\u694a\u4f73\u84d3<\/strong> (\u8ad6\u6587\u767c\u8868: Aging cell. 2020 Mar 31:e13107\u00a0)<\/p>\n<p><strong>2016\/09 <\/strong><strong>\u674e\u6085\u8aa0<\/strong><\/p>\n<p><strong>2017\/09 <\/strong><strong>\u6797\u5ead\u5b87<\/strong> (\u8ad6\u6587\u767c\u8868: J Virol. 2020 Jan 17;94(3): e01280-19)<\/p>\n<p><strong>2017\/09 <\/strong><strong>\u6c5f\u739f\u6167<\/strong> (\u8ad6\u6587\u767c\u8868: Sci Rep. 2020 Apr 22;10(1):6805)<\/p>\n<p><strong>2017\/09 <\/strong><strong>\u912d\u5ead\u4f03<\/strong> (\u8ad6\u6587\u767c\u8868: Am J Cancer Res. 2023 Sep 15;13(9):3983-4002)<\/p>\n<p><strong>2017\/09 <\/strong><strong>\u8449<\/strong><strong>\u00a0 <\/strong><strong>\u8473<\/strong> (\u8ad6\u6587\u767c\u8868:\u00a0J Virol 2022; 96(16):e0075522.)<\/p>\n<p><strong>2017\/09 <\/strong><strong>\u65bd\u6587\u4ec1<\/strong><\/p>\n<p><strong>2018\/09 <\/strong><strong>\u9ad8\u6668\u5a97<\/strong><\/p>\n<p><strong>2019\/09 <\/strong><strong>\u6c88\u5f69\u6587<\/strong><\/p>\n<p><strong>2020\/09 <\/strong><strong>\u80e1\u5247\u52fb<\/strong> (\u8ad6\u6587\u767c\u8868: Am J Cancer Res. 2023 Nov;13(10):4560-45782)<\/p>\n<p><strong>2020\/09 <\/strong><strong>\u9673\u67cf\u5b89<\/strong> (\u8ad6\u6587\u767c\u8868: Am J Cancer Res. 2024 May 15;14(5):2103-2123)<\/p>\n<p><strong>2021\/09 <\/strong><strong>\u912d\u88d5\u5f18<\/strong><\/p>\n<p><strong>2022\/09 <\/strong><strong>\u6e38\u51f1\u5a77<\/strong><\/p>\n<p><strong>2022\/09 <\/strong><strong>\u7c21\u6c9b\u82b9<\/strong><\/p>\n<p><strong>2023\/09 <\/strong><strong>\u6d2a\u8a60\u667a<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u6b77\u5c46\u535a\u58eb\u7562\u696d\u751f<\/strong><strong>:<\/strong><\/p>\n<p><strong>\u5f35\u6021\u5a77<\/strong><strong> (Sep 2014 ~ Jun 2018)<\/strong><\/p>\n<ol>\n<li>C. Chang, T.Y. Wang, <strong>Y.T. Chang<\/strong>, C.Y. Chu, C.L. Lee, H.W. Hsu, T.A. Zhou, Z. Wu, R.H. Kim, S.J. Desai, S. Liu, H.J. Kung. Autophagy Pathway Is Required for IL-6 Induced Neuroendocrine Differentiation and Chemoresistance of Prostate Cancer LNCaP Cells. PLoS ONE 2014; 9:e88556 .<\/li>\n<li>P. Lin, <strong>Y.T. Chang<\/strong>, S.Y. Lee, M. Campbell, T.C. Wang, S.H. Shen, H.J. Chung, Y.H. Chang, Allen W Chiu, C.C. Pan, C.H. Lin, C.Y. Chu, H.J. Kung, C.Y. Cheng, P.C. Chang. REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling. Oncotarget 2016; 7:26137~26151.<\/li>\n<li><strong>T. Chang<\/strong>, T.P Lin, M. Campbell, C.C. Pan, S.H. Lee, H.C. Lee, M.H. Yang, H.J. Kung, P.C. Chang. REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer. Scientific Reports 2017; 3(7):42795.<\/li>\n<li>C. Lin, <strong>Y.T. Chang<\/strong>, M. Campbell, H.C. Lee, J. C. Shih, P.C. Chang. MAOA- a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells. Scientific Reports 2017; 7:46338.<strong> [<\/strong><strong>\u7b2c\u4e00\u4f5c\u8005<\/strong><strong>]<\/strong><\/li>\n<li><strong>T. Chang<\/strong>, T.P. Lin, J.T. Tang, M. Campbell, Y.L. Luo, S.Y. Lu, C.P. Yang, T.Y. Cheng, C.H. Chang, T.T. Liu, C.H. Lin, H.J. Kung, C.C. Pan, P.C. Chang. HOTAIR is a REST-regulated LncRNA that Promotes Neuroendocrine Differentiation in Castration Resistant Prostate Cancer. Cancer Letters 2018; 433:43-52.<\/li>\n<\/ol>\n<p><strong>\u694a\u5b9b\u73ca<\/strong><strong> (Sep 2015 ~ Jun 2020) (<\/strong><strong>\u73fe\u8077<\/strong><strong>: Lerner Research Institute, Cleveland Clinic <\/strong><strong>\u535a\u58eb\u5f8c\u7814\u7a76\u54e1<\/strong><strong>)<\/strong><\/p>\n<ol>\n<li><strong>S. Yang<\/strong>, W.W. Yeh, M. Campbell, L. Chang, P.C. Chang. Long non-coding RNA KIKAT\/LINC01061 as a novel epigenetic regulator that relocates KDM4A on chromatin and modulates viral reactivation. PLoS Pathogens 2021; 17(6):e1009670.<\/li>\n<li>Campbell, <strong>W.S. Yang<\/strong>, W.W. Yeh, C.H. Kao, P.C.\u00a0Chang. Epigenetic Regulation of Kaposi&#8217;s sarcoma-associated herpesvirus Latency. Frontiers in Microbiology 2020; 19(11):850.<\/li>\n<li>P. Yang, <strong>W.S.\u00a0Yang<\/strong>, Y.H.\u00a0Wong, K.H.\u00a0Wang, Y.C.\u00a0Teng, M.H.\u00a0Chang, K.H.\u00a0Liao, F.S.\u00a0Nian, C.C.\u00a0Chao, JW\u00a0Tsai, W.L.\u00a0Hwang, M.W.\u00a0Lin, T.Y.\u00a0Tzeng, P.N.\u00a0Wang, M.\u00a0Campbell, L.K.\u00a0Chen, T.F.\u00a0Tsai, P.C.\u00a0Chang, H.J.\u00a0Kung. Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. Aging Cell 2020; 19(5):e13107.<\/li>\n<li><strong>S. Yang<\/strong>,\u00a0T.Y. Lin,\u00a0L. Chang, W.W.\u00a0Yeh, S.C.\u00a0Huang, T.Y.\u00a0Chen, Y.T.\u00a0Hsieh, S.T.\u00a0Chen, W.C.\u00a0Li,\u00a0C.C. Pan, M.\u00a0Campbell, C.H.\u00a0Yen, Y.A.\u00a0Chen, P.C.\u00a0Chang*. HIV-1 Tat Interacts with a Kaposi&#8217;s Sarcoma-Associated Herpesvirus Reactivation-Upregulated Antiangiogenic Long Noncoding RNA, LINC00313, and Antagonizes Its Function. Journal of Virology 2020; 94(3):e01280-19.<\/li>\n<li><strong>S. Yang<\/strong>, M. Campbell, H.J. Kung, P.C. Chang. In vitro SUMOylation Assay to Study SUMO E3 Ligase Activity. JoVE-Journal of Visualized Experiments 2018; 131(e56629):1-6.<\/li>\n<li><strong>S. Yang<\/strong>, M. Campbell, P.C. Chang*. SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication. PLoS Pathogens 2017; 13(2):e1006216.<\/li>\n<li><strong>S. Yang<\/strong>, H.W. Hsu, M. Campbell, C.Y. Cheng, P.C. Chang. K-bZIP mediated SUMO-2\/3 specific modification on the KSHV genome negatively regulates lytic gene expression and viral reactivation. PLoS Pathogens 2015; 11(7):e1005051<\/li>\n<\/ol>\n<p><strong>\u5f35\u9f8d<\/strong><strong> (Sep 2016 ~ Feb 2020)<\/strong><\/p>\n<ol>\n<li>Lin,<strong> L. Chang<\/strong>, H.W. Chu, H.J. Lin, P.C. Chang, R.Y.L. Wang, B. Unnikrishnan, J.Y. Mao, S.Y. Chen, C.C. Huang. High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots. Small 2019; 15(41):e1902641. <strong>[<\/strong><strong>\u7b2c\u4e00\u4f5c\u8005<\/strong><strong>]<\/strong><\/li>\n<\/ol>\n<p><strong>\u5f35\u666f\u6b23<\/strong><strong> (Sep 2016 ~ July 2024)<\/strong><\/p>\n<ol>\n<li><strong>H. Chang<\/strong>,, T.Y. Cheng, W.W. Yeh, Y.L. Luo, M. Campbell, T.C. Kuo, T.W. Shen, Y.C. Hong, C.H. Tsai, Y.C. Peng, C.C. Pan, M.H. Yang, J.C. Shih, H.J. Kung, W.J. Huang, P.C. Chang*, T.P. Lin*. REST-repressed lncRNA LINC01801 induces neuroendocrine differentiation in prostate cancer via transcriptional activation of autophagy. American Journal of Cancer Research 2023; 15;13(9):3983-4002.<\/li>\n<li><strong>H. Chang<\/strong>, P.H. Yu, P.F. Hsieh, J.H. Hong, C.H. Chiang, H.M. Cheng, H.C. Wu, C.Y. Huang, T.P. Lin. Prostate health index density aids the diagnosis of prostate cancer detected using magnetic resonance imaging targeted prostate biopsy in Taiwanese multicenter study. Journal of the Chinese Medical Association 2024; 1;87(7):678-685.<\/li>\n<\/ol>\n<\/div>\n<\/section>\n<div class=\"av-special-heading av-kznieimq-0701f956b0370fae0c34f525caf7c7f6 av-special-heading-h3 avia-builder-el-39 el_after_av_textblock el_before_av_textblock \">\n<h2 class=\"av-special-heading-tag\"><strong>Laboratory Photos<\/strong><\/h2>\n<\/div>\n<div style=\"display:flex; flex-wrap:wrap; gap:20px;\">\n<div style=\"flex:1 1 calc(33.333% - 20px); min-width:220px;\">\n    <img decoding=\"async\" src=\"\u5716\u7247\u7db2\u5740\"\n         alt=\"\u63cf\u8ff0\uff08\u4e00\uff09\"\n         style=\"width:100%; height:auto;\">\n  <\/div>\n<div style=\"flex:1 1 calc(33.333% - 20px); min-width:220px;\">\n    <img decoding=\"async\" src=\"\u5716\u7247\u7db2\u5740\"\n         alt=\"\u63cf\u8ff0\uff08\u4e8c\uff09\"\n         style=\"width:100%; height:auto;\">\n  <\/div>\n<div style=\"flex:1 1 calc(33.333% - 20px); min-width:220px;\">\n    <img decoding=\"async\" src=\"\u5716\u7247\u7db2\u5740\"\n         alt=\"\u63cf\u8ff0\uff08\u4e09\uff09\"\n         style=\"width:100%; height:auto;\">\n  <\/div>\n<\/div>\n<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":1066,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-1064","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-full-time-faculty2"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - 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