{"id":1184,"date":"2025-06-24T14:18:34","date_gmt":"2025-06-24T06:18:34","guid":{"rendered":"https:\/\/imi.nycu.edu.tw\/%e9%ab%98%e6%ad%a3%e5%bd%a5%e5%89%af%e6%95%99%e6%8e%88\/"},"modified":"2026-03-25T14:12:43","modified_gmt":"2026-03-25T06:12:43","slug":"cheng-yen-kao","status":"publish","type":"post","link":"https:\/\/imi.nycu.edu.tw\/en\/cheng-yen-kao\/","title":{"rendered":"Cheng-Yen Kao"},"content":{"rendered":"<div class=\"row\"  id=\"row-850737599\">\n\n\t<div id=\"col-681019331\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<ul>\n<li>Associate Professor<br \/>\nInstitute of Microbiology and Immunology<\/li>\n<li>Research Interests: Mechanisms of Bacterial Antibiotic Resistance; Bacterial Genomics; Virulence Factors and Bacterial Pathogenesis; Gene Regulation and Transcriptomics; Mouse Models of Bacterial Infection; Antibiotic and Probiotic Development<\/li>\n<li>Office: Room R407, Biomedical Building<\/li>\n<li>Tel (Office): +886-2-2826-7112<\/li>\n<li>Tel (Laboratory): +886-2-2826-7000 ext. 65624<\/li>\n<li>E-mail: kaocy@nycu.edu.tw<\/li>\n<li>web site:\u00a0<a href=\"https:\/\/sites.google.com\/view\/kaolab\">https:\/\/sites.google.com\/view\/kaolab<\/a><\/li>\n<li>ORCID:<a href=\"https:\/\/orcid.org\/0000-0001-8782-3912\">\u00a00000-0001-8782-3912<\/a><\/li>\n<\/ul>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-367037886\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<p><img\nfetchpriority=\"high\"\ndecoding=\"async\"\nwidth=\"1200\"\nheight=\"1545\"\nsrc=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u9ad8\u6b63\u5f65\u526f\u6559\u6388_Cheng-Yen-Kao.jpg\"\nclass=\"attachment-original size-original\"\nalt=\"\u9ad8\u6b63\u5f65\u526f\u6559\u6388\"\nsrcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u9ad8\u6b63\u5f65\u526f\u6559\u6388_Cheng-Yen-Kao.jpg 1200w,\nhttps:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u9ad8\u6b63\u5f65\u526f\u6559\u6388_Cheng-Yen-Kao-233x300.jpg 233w,\nhttps:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u9ad8\u6b63\u5f65\u526f\u6559\u6388_Cheng-Yen-Kao-795x1024.jpg 795w,\nhttps:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u9ad8\u6b63\u5f65\u526f\u6559\u6388_Cheng-Yen-Kao-768x989.jpg 768w,\nhttps:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/\u9ad8\u6b63\u5f65\u526f\u6559\u6388_Cheng-Yen-Kao-1193x1536.jpg 1193w\"\nsizes=\"(max-width: 1200px) 100vw, 1200px\"><\/p>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<p>&nbsp;<\/p>\n<\/div>\n\n\t\t<div class=\"tabbed-content\">\n\t\t\t\n\t\t\t<ul class=\"nav nav-tabs nav-uppercase nav-size-normal nav-left\" role=\"tablist\"><li id=\"tab-professional-experience\" class=\"tab active has-icon\" role=\"presentation\"><a href=\"#tab_professional-experience\" role=\"tab\" aria-selected=\"true\" aria-controls=\"tab_professional-experience\"><span>Professional Experience<\/span><\/a><\/li>\n<li id=\"tab-selected-honors-and-awards\" class=\"tab has-icon\" role=\"presentation\"><a href=\"#tab_selected-honors-and-awards\" tabindex=\"-1\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab_selected-honors-and-awards\"><span>Selected Honors and Awards<\/span><\/a><\/li>\n<li id=\"tab-publications-and-research-projects\" class=\"tab has-icon\" role=\"presentation\"><a href=\"#tab_publications-and-research-projects\" tabindex=\"-1\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab_publications-and-research-projects\"><span>Publications and Research Projects<\/span><\/a><\/li>\n<li id=\"tab-laboratory-overview\" class=\"tab has-icon\" role=\"presentation\"><a href=\"#tab_laboratory-overview\" tabindex=\"-1\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab_laboratory-overview\"><span>Laboratory Overview<\/span><\/a><\/li><\/ul><div class=\"tab-panels\"><div id=\"tab_professional-experience\" class=\"panel active entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-professional-experience\">\n<div class=\"av-special-heading av-1wyde5j-178bec8df35a0d430fe73e96c64f78ce av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<div class=\"av-special-heading av-1wyde5j-178bec8df35a0d430fe73e96c64f78ce av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<div class=\"av-special-heading av-1xclv8f-a3f0d2cecbec6a4fcaa467b70d690622 av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<h2 class=\"av-special-heading-tag\"><strong>Education<\/strong><\/h2>\n<\/div>\n<section class=\"av_textblock_section av-1v54hz3-e359758df0b4c30b96ad60df2336b97f\">\n<div class=\"avia_textblock av_inherit_color\">\n<p>\u570b\u7acb\u6210\u529f\u5927\u5b78\u57fa\u790e\u91ab\u5b78\u7814\u7a76\u6240<br \/>\n\u570b\u7acb\u6210\u529f\u5927\u5b78\u00a0 \u5206\u5b50\u91ab\u5b78\u7814\u7a76\u6240\u78a9\u58eb<br \/>\n\u570b\u7acb\u6210\u529f\u5927\u5b78\u00a0 \u57fa\u790e\u91ab\u5b78\u7814\u7a76\u6240\u535a\u58eb<br \/>\n\u570b\u7acb\u967d\u660e\u5927\u5b78 \u535a\u58eb\u5f8c\u7814\u7a76\u54e1<br \/>\nUniversity of Wisconsin-Madison\u535a\u58eb\u5f8c\u7814\u7a76\u54e1<\/p>\n<\/div>\n<\/section>\n<div class=\"av-special-heading av-1ruxb8v-6f011d695bafeaa6094dcb2643914be5 av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-12 el_after_av_hr el_before_av_textblock \">\n<h2 class=\"av-special-heading-tag\"><strong>Professional Experience<\/strong><\/h2>\n<\/div>\n<section class=\"av_textblock_section av-68vgkf-ddfe5488cc3768759f24bf7e063283e2\">\n<div class=\"avia_textblock av_inherit_color\">\n<p>2025\/01~\u7f8e\u570b\u5fae\u751f\u7269\u5b78\u6703\u99d0\u53f0\u5927\u4f7f.<br \/>\n2024\/02~\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u5fae\u751f\u7269\u53ca\u514d\u75ab\u5b78\u7814\u7a76\u6240\u526f\u6559\u6388.<br \/>\n2023\/08~\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u5fae\u83cc\u4e2d\u5fc3\u526f\u4e3b\u4efb<br \/>\n2023\/01~\u793e\u5718\u6cd5\u4eba\u53f0\u7063\u6aa2\u9a57\u53ca\u54c1\u4fdd\u5b78\u6703\u7b2c5\u5c46\u7406\u4e8b<br \/>\n2023\/01~\u53f0\u7063\u5fae\u83cc\u806f\u76df\u7b2c\u4e8c\u5c46\u79d8\u66f8\u9577<br \/>\n2023\/01~\u53f0\u7063\u5fae\u751f\u7269\u5b78\u6703\u7b2c24\u5c46\u79d8\u66f8\u9577<br \/>\n2020-2023. \u793e\u5718\u6cd5\u4eba\u53f0\u7063\u6aa2\u9a57\u53ca\u54c1\u4fdd\u5b78\u6703\u7b2c4\u5c46\u526f\u79d8\u66f8\u9577.<br \/>\n2019-2021. \u7f8e\u570b\u5fae\u751f\u7269\u5b78\u6703\u99d0\u53f0\u7063\u9752\u5e74\u5927\u4f7f.<br \/>\n2019-2022. \u53f0\u7063\u5fae\u751f\u7269\u5b78\u6703\u7b2c23\u5c46\u526f\u79d8\u66f8\u9577.<br \/>\n2019\/08-2024\/01. \u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u5fae\u751f\u7269\u53ca\u514d\u75ab\u5b78\u7814\u7a76\u6240\u526f\u6559\u6388.<\/p>\n<\/div>\n<\/section>\n<\/div>\n<section class=\"av_textblock_section av-1682wiv-8006e72fe9d03e2941376d8c27411fd8\"><\/section>\n<\/div>\n<section class=\"av_textblock_section av-1682wiv-8006e72fe9d03e2941376d8c27411fd8\"><\/section>\n<\/div>\n<div id=\"tab_selected-honors-and-awards\" class=\"panel entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-selected-honors-and-awards\">\n<h2><strong>Awards<\/strong><\/h2>\n<ol>\n<li>Emergence of extensively-drug-resistant hypervirulent <em>Acinetobacter baumannii <\/em>isolated from patients with bacteraemia: bacterial phenotype and virulence analysis\uff0c\u520a\u767b\u65bcInternational Journal of Antimicrobial Agents\uff0c\u7372\u9078\u967d\u660e\u4ea4\u901a\u5927\u5b78113\u5e74\u7b2c4\u5b63 (10-12\u6708) \u91cd\u8981\u8ad6\u6587<\/li>\n<li>Outstanding Teaching Award (National Yang Ming Chiao Tung University). 112\u5b78\u5e74\u5ea6\u967d\u660e\u4ea4\u901a\u5927\u5b78\u6559\u5b78\u5091\u51fa\u6559\u5e2b.<\/li>\n<li>2023 National Yang Ming Chiao Tung University Research Reward Subsidies (2023 Aug to 2025 Jul). 2023\u5e74\u967d\u660e\u4ea4\u901a\u5927\u5b78\u7279\u6b8a\u512a\u79c0\u6559\u7814\u4eba\u54e1\u734e\u52f5<\/li>\n<li>Excellent Teaching Award (College of Life Sciences). 110\u5b78\u5e74\u5ea6\u751f\u547d\u79d1\u5b78\u9662\u6559\u5b78\u512a\u826f\u6559\u5e2b.<\/li>\n<li>Phylogenetic Distribution of CRISPR-Cas Systems in <em>Staphylococcus lugdunensis<\/em>\uff0c\u520a\u767b\u65bcMicrobiology Spectrum\uff0c\u7372\u9078\u967d\u660e\u4ea4\u901a\u5927\u5b78110\u5e74\u7b2c4\u5b63 (10-12\u6708) \u91cd\u8981\u8ad6\u6587<\/li>\n<li>Outstanding alumni, Department of Biochemical Science and Technology, National Chia-Yi University. \u5609\u7fa9\u5927\u5b78\u751f\u5316\u79d1\u6280\u5b78\u7cfb108\u5e74\u5ea6\u5091\u51fa\u7cfb\u53cb.<\/li>\n<\/ol>\n<h2><strong>Conference Chair \/ Organizer<\/strong><\/h2>\n<ol>\n<li><span style=\"color: #333333;\">2025 Mar 22th. (Invited talk &amp; Modulator). Culturomics: The bottleneck in validating a strain\u2019s role in microbiota research and product development. <\/span><em style=\"color: #333333;\">The 8th Annual Conference of Taiwan Microbiota Consortium<\/em><span style=\"color: #333333;\">(2025 ACTMC) &amp; The 3rd Annual Conference of Asia Pacific Microbiota Consortium. National Taiwan University Hospital.<\/span><\/li>\n<li>2024 Oct 5<sup>th<\/sup>. (Moderator). \u7b2c\u4e00\u5c46\u5fae\u751f\u7269\u7d44\u548c\u4ee5\u5fae\u751f\u7269\u7d44\u70ba\u57fa\u790e\u7684\u6cbb\u7642\u5b78\u7814\u8a0e\u6703 1st Symposium on Microbiome and Microbiome-Based Therapeutics (SMMT). Conference rooms, Research Building, 1st Floor, Chang Gung Memorial Hospital, Taiwan.<\/li>\n<li>2022 Aug 25<sup>th<\/sup>-27<sup>th<\/sup>. Committee Chair \u2013 26<sup>th<\/sup> Bacteriology conference. 2022\u53f0\u7063\u7b2c26\u5c46\u7d30\u83cc\u5b78\u7814\u8a0e\u6703.National Yang Ming Chiao Tung University, HsinChu, Taiwan.<\/li>\n<li>2019 Aug 31<sup>st<\/sup>. Committee Chair &#8211; Hot topics in the 119th ASM General Meeting-\u7d30\u83cc\u8a3a\u65b7\u8207\u6297\u85e5\u6027\u65b0\u77e5\u7814\u8a0e\u6703 (Co-hosted by ASM, TSM, and NYMU) National Yang-Ming University.<\/li>\n<\/ol>\n<h2><strong>Invited International Talks<\/strong><\/h2>\n<ol>\n<li>Apr 8th. (Invited talk). Diversity of virulence plasmids and phenotypes in carbapenem-resistant <em>Klebsiella pneumoniae<\/em> and liver abscess-associated <em>Klebsiella pneumoniae.<\/em> 2025\u00a0<em>International Symposium on Molecular Sciences.<\/em> University of Santo Tomas, Manila, Philippins.<\/li>\n<li>2025 Mar 22th. (Invited talk &amp; Modulator). Culturomics: The bottleneck in validating a strain\u2019s role in microbiota research and product development. <em>The 8th Annual Conference of Taiwan Microbiota Consortium<\/em>(2025 ACTMC) &amp; The 3rd Annual Conference of Asia Pacific Microbiota Consortium. National Taiwan University Hospital.<\/li>\n<li>2025 Jan 11<sup>th<\/sup>. (Invited talk). From Biomarkers to Genomics: Decoding Virulence and Plasmids in Carbapenem-Resistant Hypervirulent <em>Klebsiella pneumoniae<\/em>. Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya.<\/li>\n<li>2024 Aug 15<sup>th<\/sup>. (Invited talk). Integrating Fundamental and Applied Microbiology Research to Tackle Urgent Clinical Treatment Challenges. Nanotechnology &amp; Catalysis Research Centre (NANOCAT), Universiti Malaya.<\/li>\n<li>2023 July 6<sup>th<\/sup>-8<sup>th<\/sup>. <em>In Vivo<\/em> Evolution of <em>Escherichia coli<\/em> and Recurrent Urinary Tract Infections. (Invited talk). 19th\u00a0The Asia Pacific Congress of Clinical Microbiology &amp; Infection\u00a0(APCCMI) Seoul, Korea.<\/li>\n<li>2023 May 3<sup>rd<\/sup>. Characterization of the in vivo evolution of pathogens isolated from patients with recurrent urinary tract infections. (Invited talk). PROGRAMME 1ST INTERNATIONAL SCIENTIFIC CONFERENCE ON MICROBIOLOGY-2023. Ulaanbaatar city, Mongolia.<\/li>\n<li>2019 Aug 31<sup>st<\/sup>. New pipeline drugs for post-antibiotic era. (Conference invited talk). Hot topics in the 119th ASM General Meeting-2019\u7d30\u83cc\u8a3a\u65b7\u8207\u6297\u85e5\u6027\u65b0\u77e5\u7814\u8a0e\u6703. National Yang-Ming University, Taipei, Taiwan.<\/li>\n<li>Sep 30<sup>th<\/sup>. A novel screen suggests that regulation of fermentation is critical for cytosolic survival and virulence of <em>Listeria monocytogenes<\/em>. (Conference invited talk). 25<sup>th<\/sup> Annual Midwest Microbial Pathogenesis Conference, University of Iowa, Iowa, IA (MMPC).<\/li>\n<\/ol>\n<\/div>\n<div id=\"tab_publications-and-research-projects\" class=\"panel entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-publications-and-research-projects\">\n<div class=\"av-special-heading av-10md8rr-c752fab7bc091682958c7effdda61054 av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-25 el_after_av_hr el_before_av_textblock \">\n<div class=\"av-special-heading av-119zicf-fe0cbcb596da82d940a795e95a0e6b9a av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-26 el_after_av_hr el_before_av_textblock \">\n<h2 class=\"av-special-heading-tag\"><strong>Publications<\/strong><\/h2>\n<\/div>\n<section class=\"av_textblock_section av-yxqo8v-5d8d218ab6431b7931bac3ce50f30fe8\">\n<div class=\"avia_textblock\">\n<p><strong>2025:<\/strong><\/p>\n<ul>\n<li>Optimization and spectrum characterization of the antibacterial activity of lugdunin.\u00a0<strong><u>Kao CY<\/u><\/strong><u>,<\/u>Longjama N, Hidrosollo JH, Lin LC, Lu JJ. International Journal of Medical Microbiology. (In revision).<\/li>\n<li>Hha of the toxin-antitoxin system regulates diverse phenotypes of uropathogenic\u00a0<em>Proteus mirabilis<\/em> Chao YJ, Lee YJ, Chen HH,\u00a0<strong><u>Kao CY<\/u><\/strong>, Liaw SJ.\u00a0J Microbiol Immunol Infect.\u00a0(In revision).<\/li>\n<li>Isolation and characterization of lytic bacteriophage against carbapenem-resistant\u00a0<em>Enterobacter cloacae<\/em> Kuo HY, Bregente CJB, Thuy TTD, Hidrosollo JH, Cruz-Papa DMD, Gutierrez TA, Huang YT, Chuang YJ, Hsueh PR,\u00a0<strong><u>Kao CY.<\/u><\/strong>Microbiology Spectrum.\u00a0(In revision).<\/li>\n<li>Tracing the evolutionary dynamics of carbapenem-resistant\u00a0<em>Escherichia coli<\/em>in recurrent and multi-site infections. Cheng YY, Tsai YM, Chuang YC, Fan YH, Wang MC, Chen YC, Teng CH, Kuo PY, Thuy TTD, Bregente CJB, Zhang YZ, Lee YH, Ho DZ,\u00a0<strong><u>Kao CY.<\/u>\u00a0<\/strong>\u00a0Gut pathogens.\u00a0(In revision).<\/li>\n<li>Rising threat of metallo-\u03b2-lactamase-producing\u00a0<em>Klebsiella oxytoca\u00a0<\/em>complex in Taiwan. 2013-2022. Huang YT, Bregente CJB, Liao CH, Kuo YW, Lee TF,\u00a0<strong><u>Kao CY*,<\/u><\/strong>Hsueh PR*.\u00a0(*equal contribution). Int J Antimicrob Agents.\u00a02025 Aug;66(2):107515. doi: 10.1016\/j.ijantimicag.2025.107515.\u00a0(SCI, IF: 4.6, Ranking: 17\/137 Infectious Diseases).<\/li>\n<li>Indolenine-substituted pyrazole derivative 4e inhibits planktonic\u00a0<em>Staphylococcus lugdunensis<\/em>growth and biofilm formation by disrupting purine biosynthesis and cell wall integrity. Hidrosollo JH, Liao HW, Yap CH, James JJ, Lu JJ, Tai YH, Wei CC, Thuy TTD, Chin SP, Tay ST*, Chee CF*,\u00a0<strong><u>Kao CY*.<\/u><\/strong>\u00a0(*equal contribution).\u00a0Antimicrob Agents Chemother.\u00a02025 Jul 23:e0019925. doi: 10.1128\/aac.00199-25.\u00a0(SCI, IF: 4.5, Ranking:\u00a064\/352\u00a0Pharmacology &amp; Pharmacy).<\/li>\n<li>Regulatory Networks in\u00a0<em>Helicobacter pylori<\/em>: The Roles of Two-Component Systems and CsrA in Stress Adaptation. Kuo PY,\u00a0<strong><u>Kao CY.<\/u><\/strong>J Microbiol Immunol Infect.\u00a0J Microbiol Immunol Infect. 2025 Jul 1:S1684-1182(25)00132-X. doi: 10.1016\/j.jmii.2025.06.009.\u00a0(SCI, IF: 3.7, Ranking: 35\/137 Infectious Diseases).<\/li>\n<li>Study of\u00a0<em>lug\u00a0<\/em>operon, SCC<em>mec<\/em>elements, antimicrobial resistance, MGEs and STs of\u00a0<em>Staphylococcus lugdunensis<\/em>\u00a0clinical isolates through whole-genome sequencing. Chang TY, Lin LC,\u00a0\u00a0<strong><u>Kao CY.<\/u>\u00a0<\/strong>Lu JJ.\u00a0Int J Mol Sci. 2025 Jun 25;26(13):6106. doi: 10.3390\/ijms26136106.\u00a0(SCI, IF: 4.9, Ranking: 72\/319 Biochemistry &amp; Molecular biology).<\/li>\n<li>Compositional and metabolomic shifts of the gut microbiome in alcohol-related liver disease. Kuo CH,\u00a0El-Omar EM,\u00a0<strong><u>Kao CY<\/u><\/strong>,\u00a0Lin JT, Wu\u00a0CY.\u00a0Journal of Gastroenterology and Hepatology.\u00a0J Gastroenterol Hepatol. 2025 Jun 24. doi: 10.1111\/jgh.17038.\u00a0(SCI, IF:\u00a03.4, Ranking:\u00a047\/147\u00a0Gastroenterology &amp; Hepatology).<\/li>\n<li>The development of live biotherapeutic products: A position statement of Asia-Pacific Microbiome Consortium. Tseng CH, Wong SH, Yu J, Lee YY, Terauchi J, Lai HC, Luo JC,\u00a0<strong><u>Kao CY,<\/u><\/strong>Yu SL, Liou JM, Wu DC, Hou MC, Wu MS, Wu JJ, Sung JJY,\u00a0El-Omar EM, Wu CY. Gut. 2025 Apr 7;74(5):706-713. doi: 10.1136\/gutjnl-2024-334501.\u00a0(SCI, IF: 25.8, Ranking: 4\/147 Gastroenterology &amp; Hepatology).<\/li>\n<li>O-antigen of uropathogenic\u00a0<em>Escherichia coli\u00a0<\/em>is required for induction of neutrophil extracellular traps. Lin WH, Sheu SM, Wu CF, Huang WC, Hsu LJ, Yu KC, Cheng HC,\u00a0<strong><u>Kao CY<\/u><\/strong>, Wu JJ, Wang MC, Teng CH. J Microbiol Immunol Infect. 2025 Apr;58(2):209-218. doi: 10.1016\/j.jmii.2024.12.007.\u00a0(SCI, IF:\u00a03.7, Ranking:\u00a035\/137\u00a0Infectious Diseases).<\/li>\n<li>An Integrated Platform for Investigating Drug-Microbial Interactions to Support Pharmacomicrobiomics Studies. Tai YH*,\u00a0<strong><u>Kao CY*<\/u><\/strong>, Zhang YP, Chiou YJ, Chiu HH, Thuy TTD, Liao HW. (*equal contribution).\u00a0Talanta. 2025 Feb 1;283:127094. doi: 10.1016\/j.talanta.2024.127094. Epub 2024 Oct 24.\u00a0(SCI, IF:\u00a06.1, Ranking: 14\/111\u00a0Chemistry, Analytical).<\/li>\n<li>Antibacterial effects and mechanism of action of Low Energy Shock Waves on uropathogenic\u00a0<em> coli<\/em>investigated by\u00a0<em>in vitro<\/em>\u00a0and\u00a0<em>in vivo<\/em>\u00a0cystitis rat model. Wu ZS,\u00a0<strong><u>Kao CY<\/u><\/strong>, Wang HJ, Lee WC, Luo HL, Huang CC, Chuang YC.\u00a0Int Urol Nephrol. 2025 Jan;57(1):49-61. doi: 10.1007\/s11255-024-04173-8.\u00a0(SCI, IF: 1.9, Ranking: 69\/133\u00a0Urology &amp; Nephrology).<\/li>\n<\/ul>\n<p><strong>2024:<\/strong><\/p>\n<ul>\n<li>Molecular characterization of colistin-resistant\u00a0<em>Klebsiella pneumoniae<\/em>isolates and their conjugative\u00a0<em>mcr<\/em>-carrying plasmids.\u00a0<strong><u>Kao CY*<\/u><\/strong>, Kuo PY*, Lin CC, Cheng YY, Wang MC, Chen YC, Lin WH. (*equal contribution). J Infect Public Health. 2024 Dec;17(12):102588. doi: 10.1016\/j.jiph.2024.102588. Epub 2024 Nov 7.\u00a0(SCI, IF: 4.0, Ranking:\u00a057\/419\u00a0Public, Environmental &amp; Occupational Health).<\/li>\n<li>Emergence of extensively drug-resistant hypervirulent\u00a0<em>Acinetobacter baumannii<\/em>isolated from patients with bacteremia: bacterial phenotype and virulence analysis. Chen PK, Liu CY, Kuo HY, Lee YT, Liu YH, Zhang YZ,\u00a0<strong><u>Kao CY<\/u>.<\/strong>\u00a0Int J Antimicrob Agents.\u00a02024 Dec;64(6):107358. doi: 10.1016\/j.ijantimicag.2024.107358.\u00a0(SCI, IF: 4.6, Ranking: 17\/137 Infectious Diseases).<\/li>\n<li>Defect Engineered Bi2Te3 Nanosheets with Enhanced Haloperoxidase Activity for Marine Antibiofouling. Kulkarnia SS, Tong DK, Wu CT,\u00a0<strong><u>Kao CY<\/u><\/strong>, Chattopadhyaya S. 2024.\u00a0Small. 2024 Oct;20(43):e2401929. doi: 10.1002\/smll.202401929.\u00a0(SCI, IF: 12.1, Ranking:\u00a014\/187\u00a0Physics, Applied).<\/li>\n<li>First report of the chromosomal integration of carbapenemase gene\u00a0<em>bla<\/em>IMP-19 in\u00a0<em>Acinetobacter baumannii<\/em>AB322: the legacy of integron in phage-plasmid?\u00a0Shih YL, Bregente CJB, Chen PK, Thuy TTD, Chen YC, Kuo HY, Lu HF,\u00a0<strong><u>Kao CY<\/u><\/strong>. Microbiol Spectr. 2024 Jun 4;12(6):e0038224. doi: 10.1128\/spectrum.00382-24.\u00a0(SCI, IF:\u00a03.8, Ranking:\u00a058\/163\u00a0Microbiology).<\/li>\n<li>Peptidoglycan endopeptidase MepM of uropathogenic\u00a0<em>Escherichia coli<\/em>contributes to competitive fitness during urinary tract infections.\u00a0Huang WC, Dwija IBNP, Hashimoto M, Wu JJ, Wang MC,\u00a0<strong><u>Kao CY<\/u><\/strong>, Lin WH, Wang S, Teng CH. BMC Microbiol.\u00a02024 May 30;24(1):190. doi: 10.1186\/s12866-024-03290-9.\u00a0(SCI, IF: 4.2, Ranking:\u00a046\/163\u00a0Microbiology).<\/li>\n<li>A 19-year longitudinal study to characterize carbapenem-nonsusceptible\u00a0<em>Acinetobacter\u00a0<\/em>isolated from patients with bloodstream infections and the contribution of conjugative plasmids to carbapenem resistance and virulence.\u00a0Chen PK*, Lee YT*, Liu CY*, Anh K,\u00a0Thuy TTD, Wu JJ,\u00a0Liao CH, Huang YT, Chen YC,\u00a0<strong><u>Kao CY<\/u><\/strong>. (*equal contribution). J Microbiol Immunol Infect. 2024 Apr;57(2):288-299. doi: 10.1016\/j.jmii.2024.01.008. Epub 2024 Feb 8.\u00a0(SCI, IF: 3.7, Ranking: 35\/137 Infectious Diseases).<\/li>\n<li>Molecular characterization of lugdunin inactivation mechanisms and their association with\u00a0<em>Staphylococcus lugdunensis<\/em>genetic types. Lin LC*,\u00a0<strong><u>Kao CY*<\/u><\/strong>, Chang SC, Hidrosollo JH, Lu JJ. (*equal contribution). J Microbiol Immunol Infect. 2024 Apr;57(2):278-287. doi: 10.1016\/j.jmii.2024.01.005. Epub 2024 Jan 20.\u00a0(SCI, IF: 3.7, Ranking: 35\/137 Infectious Diseases).<\/li>\n<li>Characterization of the broad-spectrum antibacterial activity of bacteriocin-like inhibitory substance-producing probiotics isolated from fermented foods. Thuy TTD*,\u00a0Lu HF*,\u00a0Bregente CJB,\u00a0Huang FCA, Tu PC,\u00a0<strong><u>Kao CY<\/u><\/strong>.\u00a0BMC Microbiol. 2024 Mar 11;24(1):85. doi: 10.1186\/s12866-024-03245-0.\u00a0(SCI, IF: 4.2, Ranking: 46\/163 Microbiology).<\/li>\n<li>A longitudinal epidemiology study of fluoroquinolone-nonsusceptible\u00a0<em>Klebsiella pneumoniae<\/em>reveals an increasing prevalence of\u00a0<em>qnrB\u00a0<\/em>and\u00a0<em>qnrS\u00a0<\/em>in Taiwan. Kuo PY*, Lin WH*, Tang SF, Cheng YY, Bregente CJB, Duong TTT, Wang MC, Teng CH, Hsieh YH, Tsai PF, Li YC,\u00a0<strong><u>Kao CY<\/u><\/strong>. (*equal contribution). J Infect Public Health. 2024 Mar;17(3):457-463. doi: 10.1016\/j.jiph.2024.01.005. (SCI, IF: 4.0, Ranking: 57\/419 Public, Environmental &amp; Occupational Health).<\/li>\n<\/ul>\n<p><strong>2023:<\/strong><\/p>\n<ul>\n<li>Characterization of uropathogenic\u00a0<em>Escherichia coli\u00a0<\/em>phylogroups associated with antimicrobial resistance, virulence factor distribution, and virulence-related phenotypes.\u00a0Wang MC*, Fan YH*,\u00a0Zhang YZ,\u00a0Bregente CJB,\u00a0Lin WH, Lin TP, Chen CA,\u00a0<strong><u>Kao CY.<\/u><\/strong>(*equal contribution).\u00a0Infect Genet Evol. 2023 Oct;114:105493. doi: 10.1016\/j.meegid.2023.105493.\u00a0(SCI, IF: 2.6, Ranking: 63\/137\u00a0Infectious Diseases).<\/li>\n<li>Lugdunin production and activity in\u00a0<em>Staphylococcus lugdunensis<\/em>bloodstream isolates are associated with its genotypes.\u00a0Chang SC*,\u00a0<strong><u>Kao CY*<\/u><\/strong>, Lin LC, Hidrosollo JH, Lu JJ.\u00a0(*equal contribution).\u00a0Microbiol Spectr. 2023 Sep 21;11(5):e0129823. doi: 10.1128\/spectrum.01298-23.\u00a0(SCI, IF:\u00a03.8, Ranking:\u00a058\/163\u00a0Microbiology).<\/li>\n<li>A 24-year longitudinal study of\u00a0<em>Klebsiella pneumoniae<\/em>isolated from patients with bacteremia and urinary tract infections reveals the association between capsular serotypes, antibiotic resistance, and virulence gene distribution.\u00a0<strong><u>Kao CY<\/u><\/strong>, Zhang YZ, Bregente CJB, Kuo PY,\u00a0Chen PK,\u00a0Chao JY, Duong TTT, Wang MC, Thuy TTD,\u00a0Hidrosollo JH, Tsai PF, Li YC,\u00a0Lin WH.\u00a0Epidemiol Infect. 2023 Sep 7;151:e155.\u00a0doi: 10.1017\/S0950268823001486.\u00a0(SCI, IF:\u00a02.2, Ranking:\u00a0183\/419\u00a0Public, Environmental &amp; Occupational Health).<\/li>\n<li>Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 MAPK-mediated mitochondrial and autophagic apoptosis. Lai CP, Chen YS, Ying TH,\u00a0<strong><u>Kao CY<\/u><\/strong>,\u00a0Chiou HL, Kao SH, Hsieh YH.\u00a0Kidney Res Clin Pract. 2023 Jul;42(4):487-500.\u00a0doi: 10.23876\/j.krcp.22.114.\u00a0(SCI, IF:\u00a03.8, Ranking:\u00a021\/133\u00a0Urology &amp; Nephrology).<\/li>\n<li>Sequential isolation of metabolites and lipids for the same sample to achieve multiomics by using TRIzol reagent.\u00a0<strong><u>Kao CY*<\/u><\/strong>, Chang CT*, Kuo PY, Lin CJ, Chiu HH, Liao HW.\u00a0(*equal contribution).\u00a0Talanta.\u00a02023 Jun 1:258:124416. doi: 10.1016\/j.talanta.2023.124416.\u00a0(SCI, IF: 6.1, Ranking: 14\/111 Chemistry, Analytical).<\/li>\n<li>Genome-based characterization of conjugative IncHI1B plasmid carrying carbapenemase genes\u00a0<em>bla<\/em><sub>VIM-1<\/sub>,\u00a0<em>bla<\/em><sub>IMP-23<\/sub>, and truncated\u00a0<em>bla<\/em><sub>OXA-256\u00a0<\/sub>in\u00a0<em>Klebsiella pneumoniae<\/em> Wen LL, Kuo PY,\u00a0Thuy TTD, Duong TTT, Huang YT, Hseuh PR, Chen YC,\u00a0<strong><u>Kao CY<\/u><\/strong><u>.<\/u>Infect Genet Evol.\u00a02023 Jun;110:105420. doi: 10.1016\/j.meegid.2023.105420.\u00a0(SCI, IF: 2.6, Ranking: 63\/137 Infectious Diseases).<\/li>\n<li>Characterization of oxacillin-resistant\u00a0<em>Staphylococcus lugdunensis<\/em>isolated from sterile body fluids in a medical center in Taiwan: a 12-year longitudinal epidemiological study.\u00a0Chang SC,\u00a0Hidrosollo JH,\u00a0Lin LC, Ou YH,\u00a0<strong><u>Kao CY*<\/u><\/strong>, Lu JJ*.\u00a0(*equal contribution).\u00a0J Microbiol Immunol Infect.\u00a02023 Apr;56(2):292-298. doi: 10.1016\/j.jmii.2022.08.021.\u00a0(SCI, IF: 3.7, Ranking: 35\/137 Infectious Diseases).<\/li>\n<li>Characterization of host and\u00a0<em>Escherichia coli<\/em>strains causing recurrent urinary tract infections based on molecular typing.\u00a0<strong><u>Kao CY<\/u><\/strong>, Zhang YZ, Yang DC, Chen PK, Teng CH, Lin WH, Wang MC.\u00a0BMC Microbiol. 2023 Mar 30;23(1):90.\u00a0doi:\u00a010.1186\/s12866-023-02820-1.\u00a0(SCI, IF: 4.2, Ranking: 46\/163 Microbiology).<\/li>\n<li>Licochalcone A Suppresses Renal Cancer Cell Proliferation and Metastasis by Engagement of Sp1-Mediated LC3 Expression. Tseng TY, Lee CH, Lee HL, Su CY,\u00a0<strong><u>Kao CY<\/u><\/strong>, Tsai JP, Hsieh YH.\u00a0Pharmaceutics. 2023 Feb 17;15(2):684. doi: 10.3390\/pharmaceutics15020684.\u00a0(SCI, IF:\u00a05.5, Ranking:\u00a034\/352\u00a0Pharmacology &amp; Pharmacy).<\/li>\n<\/ul>\n<p><strong>2022:<\/strong><\/p>\n<ul>\n<li>Anti-<em>Helicobacter pylori<\/em>activity of potential probiotic\u00a0<em>Lactiplantibacillus<\/em>\u00a0<em>pentosus<\/em>\u00a0Thuy TTD, Kuo PY, Lin SM,\u00a0<strong><u>Kao CY<\/u><\/strong>.\u00a0BMC Microbiol. 2022 Nov 21;22(1):277.\u00a0\u00a0doi: 10.1186\/s12866-022-02701-z.\u00a0(SCI, IF: 4.2, Ranking: 46\/163 Microbiology).<\/li>\n<li>Heparin is required for the formation of granules in connective tissue mast cells.\u00a0<a href=\"https:\/\/loop.frontiersin.org\/people\/126472\/overview\">Dzhagalov<\/a>I,\u00a0<a href=\"https:\/\/loop.frontiersin.org\/people\/1928196\/overview\">Herrera-Heredia<\/a>\u00a0SA, Hsu HP,\u00a0<strong><u>Kao CY<\/u><\/strong>, Tsai YH, Yamaguchi Yu, Roers A, Hsu CL.\u00a0Front Immunol. 2022 Nov 9;13:1000405.\u00a0doi:\u00a010.3389\/fimmu.2022.1000405.\u00a0(SCI, IF:\u00a05.9, Ranking:\u00a032\/183\u00a0Immunology).<\/li>\n<li>Plasmid-mediated quinolone resistance determinants in fluoroquinolone-nonsusceptible\u00a0<em>Escherichia coli<\/em>isolated from patients with urinary tract infections in a university hospital in Taiwan, 2009-2010 and 2020. Kuo PY, Lo YT, Chiou YJ, Chen CA,\u00a0Hidrosollo JH, Thuy TTD,\u00a0Zhang YZ, Wang MC, Lin TP, Lin WH*,\u00a0<strong><u>Kao CY<\/u><\/strong>*.\u00a0(*equal contribution).\u00a0J Glob Antimicrob Resist.\u00a02022 Sep;30:241-248. doi: 10.1016\/j.jgar.2022.06.004.\u00a0(SCI, IF: 3.2, Ranking:\u00a043\/137 Infectious Diseases).<\/li>\n<li>Whole-genome-sequence-based characterization of an extensively drug-resistant uropathogenic\u00a0<em>Escherichia coli<\/em> Thuy TTD*, Lu HF*,\u00a0Kuo PY*,\u00a0Lin WH, Lin TP, Lee YZ, Duong TTT, Wang MC, Lee YH, Wen LL, Chen YC,\u00a0<strong><u>Kao CY<\/u>.<\/strong>(*equal contribution). BMC Microbiol. 2022 Jun 6;22(1):150.\u00a0\u00a0doi:10.1186\/s12866-022-02562-6\u00a0(SCI, IF: 4.2, Ranking: 46\/163 Microbiology).<\/li>\n<li>Uremic Toxin Producing\u00a0<em>Bacteroides<\/em>Species Prevail the Gut Microbiota of Taiwanese CKD patients: An analysis using a new Taiwan Microbiome Baseline.\u00a0Shivani S*,\u00a0<strong><u>Kao CY*<\/u><\/strong>,\u00a0Amrita C,\u00a0Chen JW, Lai LC, Lin WH, Lu TP, Huang IH, Tsai MH, Teng CH, Wu JJ, Hsieh YH, Wang MC, Chuang EC. (*equal contribution).\u00a0Front Cell Infect Microbiol.\u00a02022 Apr 26;12:726256. doi: 10.3389\/fcimb.2022.726256\u00a0(SCI, IF:\u00a04.8, Ranking:\u00a032\/163\u00a0Microbiology).<\/li>\n<li><em>Escherichia coli<\/em>urinary tract infections: host age-related differences in bacterial virulence factors and antimicrobial susceptibility.\u00a0Lin WH, Wang MC, Liu<sup>\u00a0<\/sup>PY, Chen<sup>\u00a0<\/sup>PS, Wen LL, Teng CH,\u00a0<strong><u>Kao CY<\/u><\/strong>.\u00a0J Microbiol Immunol Infect.\u00a0\u00a02022 Apr;55(2):249-256. doi: 10.1016\/j.jmii.2021.04.001.\u00a0(SCI, IF: 3.7, Ranking: 35\/137 Infectious Diseases).<\/li>\n<li>Accurate Detection of Oxacillin-Resistant\u00a0<em>Staphylococcus lugdunensis<\/em>by Use of Agar Dilution.\u00a0<strong><u>Kao CY<\/u>*<\/strong>, Wu HH*, Chang SC, Lin LC, Liu TP,\u00a0 Lu JJ. (*equal contribution).\u00a0J Microbiol Immunol Infect.\u00a02022 Apr;55(2):234-240. doi: 10.1016\/j.jmii.2021.02.009.\u00a0(SCI, IF: 3.7, Ranking: 35\/137 Infectious Diseases).<\/li>\n<li>A longitudinal\u00a09-year study of the molecular epidemiology of carbapenem-resistant\u00a0<em>Enterobacteriaceae\u00a0<\/em>isolated from a regional hospital in northern Taiwan: Predominance of carbapenemase KPC-2 and OXA-48. Duong TTT*,\u00a0Tsai YM*, Wen LL, Chiu HC, Chen PK, Thuy TTD, Kuo PY, Hidrosollo JH, Wang S, Zhang YZ, Lin WH, Wang MC,\u00a0<strong><u>Kao CY<\/u><\/strong>.\u00a0(*equal contribution).\u00a0Front Microbiol.\u00a02022 Mar 11;13:703113.\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.3389\/fmicb.2022.703113\">3389\/fmicb.2022.703113<\/a>(SCI, IF: 4.5, Ranking:\u00a038\/163\u00a0Microbiology).<\/li>\n<\/ul>\n<p><strong>2021:<\/strong><\/p>\n<ul>\n<li>Phylogenetic Distribution of CRISPR-Cas Systems in\u00a0<em>Staphylococcus lugdunensis.<\/em><strong><u>Kao CY*<\/u><\/strong>, Lu JJ*, Lin LC, Lin HC, Chang SC. (*equal contribution).\u00a0Microbiol Spectr. 2021 Dec 22;9(3):e0124721. doi: 10.1128\/spectrum.01247-21.\u00a0(SCI, IF:\u00a03.8, Ranking:\u00a058\/163\u00a0Microbiology).<\/li>\n<li>Untargeted Microbial Exometabolomics and Metabolomics Analysis of\u00a0<em>Helicobacter pylori\u00a0<\/em>J99 and\u00a0<em>jhp0106<\/em><strong><u>Kao CY<\/u><\/strong>, Kuo PY, Liao HW. Metabolites. 2021 Nov;11(12), 808; doi:10.3390\/metabo11120808. (SCI, IF:\u00a03.47, Ranking:\u00a0124\/319\u00a0Biochemistry &amp; Molecular biology)<\/li>\n<li>Distinct Characteristics of\u00a0<em>Escherichia coli<\/em>Isolated from Patients with Urinary Tract Infections in a Medical Center at A Ten-Year Interval. Lin WH*, Zhang YZ*, Liu PY*, Chen PS, Wang S, Kuo PY, Thuy TTD, Duong TTT, Wen LL, Hsieh YH, Wang MC,\u00a0<strong><u>Kao CY<\/u><\/strong>. (*equal contribution). Pathogens. 2021 Sep 8;10(9):1156.\u00a0doi: 10.3390\/pathogens10091156\u00a0(SCI, IF: 3.3, Ranking: 74\/163 Microbiology)<\/li>\n<li>Glycosyltransferase Jhp0106 (PseE) contributes to flagellin maturation in\u00a0<em>Helicobacter pylori<\/em>.\u00a0Yang KY*,\u00a0<strong><u>Kao CY<\/u>*<\/strong>, Su SW Marcia*, Wang S, Chen YL, Hu ST, Chen JW, Teng CH, Tsai PJ, Wu JJ. (*equal contribution).\u00a0Helicobacter. 2021 Apr;26(2):e12787. doi: 10.1111\/hel.12787. Epub 2021 Feb 15.\u00a0(SCI, IF: 4.3, Ranking:\u00a034\/147\u00a0Gastroenterology &amp; Hepatology)<\/li>\n<\/ul>\n<p><strong>2020:<\/strong><\/p>\n<ul>\n<li>Combination of modified carbapenem inactivation method (mCIM) and EDTA-CIM (eCIM) for phenotypic detection of carbapenemase-producing\u00a0<em>Enterobacteriaceae<\/em>.\u00a0Tsai YM, Wang S, Chiu HC,\u00a0<strong><u>Kao CY<\/u>*<\/strong>, Wen LL*. (*equal contribution).\u00a0BMC Microbiol. 2020 Oct 17;20(1):315. doi: 10.1186\/s12866-020-02010-3.\u00a0(SCI, IF: 4.2, Ranking: 46\/163 Microbiology).<\/li>\n<li>Defeating antibiotic-resistant bacteria: exploring alternative drug targets for a post-antibiotic era. Wang CH, Hsieh YH, Zach P,\u00a0<strong><u>Kao CY<\/u><\/strong>.\u00a0Int J Mol Sci. 2020 Feb 5;21(3). pii: E1061. doi: 10.3390\/ijms21031061. (SCI, IF: 4.9, Ranking: 72\/319 Biochemistry &amp; Molecular biology)<\/li>\n<\/ul>\n<p><strong>2019:<\/strong><\/p>\n<ul>\n<li>Mutation of the transcriptional regulator YtoI rescues Listeria monocytogenes mutants deficient in the essential shared metabolite 1,4-dihydroxy-2-naphthoate (DHNA). Chen GY*,\u00a0<strong><u>Kao CY*<\/u><\/strong>, Smith H, Rust D, Zach P, Li AY, Sauer JD. (*equal contribution). Infect Immun.\u00a02019 Dec 17;88(1). pii: e00366-19. doi: 10.1128\/IAI.00366-19.\u00a0(SCI, IF: 2.8, Ranking: 57\/137 Infectious disease)<\/li>\n<li>Fermented soymilk and soy and cow milk mixture, supplemented with orange peel fiber or\u00a0<em>Tremella<\/em><em>flava<\/em>\u00a0fermented powder as prebiotics for high EPS-producing\u00a0<em>Lactobacillus pentosus<\/em>\u00a0SLC 13. Huang ML, Huang JY,\u00a0<strong><u>Kao CY<\/u><\/strong>, Fang TJ. J Sci Food Agric. 2019 Jul;99(9):4373-4382. doi: 10.1002\/jsfa.9671.\u00a0(SCI, IF: 3.5, Ranking: 18\/94 Agriculture, Multidisciplinary)<\/li>\n<\/ul>\n<p><strong>2018:<\/strong><\/p>\n<ul>\n<li>Characterization of CRISPR-Cas systems in Clinical\u00a0<em>Klebsiella pneumoniae<\/em>Isolates Uncovers its Potential Association with Antibiotic Susceptibility. Li HY*,\u00a0<strong><u>Kao CY<\/u>*<\/strong>, Lin WH, Zheng PX, Yan JJ, Wang MC, Teng CH, Wu JJ. (*equal contribution). Front Microbiol. 2018 Jul 16;9:1595. doi: 10.3389\/fmicb.2018.01595.\u00a0(SCI, IF: 4.5, Ranking: 38\/163 Microbiology).<\/li>\n<li>Comparative Genomics of\u00a0<em>Escherichia coli<\/em>Sequence Type 219 Clones from the Same Patient: Evolution of the IncI1\u00a0<em>bla<\/em>CMY-Carrying Plasmid\u00a0<em>in Vivo<\/em>.\u00a0\u00a0<strong><u>Kao CY<\/u><\/strong>, Chen JW, Liu TL, Yan JJ, Wu JJ. Front Microbiol. 2018 Jul 16;9:1518. doi: 10.3389\/fmicb.2018.01518.\u00a0(SCI, IF: 4.5, Ranking: 38\/163 Microbiology).<\/li>\n<li>Complete genome sequence of\u00a0<em>Lactobacillus pentosus<\/em>SLC13, isolated from mustard pickles, a potential probiotic strain with antimicrobial activity against foodborne pathogenic microorganisms. Huang ML, Huang JY,\u00a0<strong><u>Kao CY<\/u><\/strong>, Fang TJ. Gut Pathog. 2018 Jan 18;10:1. doi: 10.1186\/s13099-018-0228-y. eCollection 2018.\u00a0(SCI, IF: 4.0, Ranking: 35\/147\u00a0Gastroenterology &amp; Hepatology)<\/li>\n<\/ul>\n<p><strong>2017:\u00a0<\/strong><\/p>\n<ul>\n<li>Inactivation of ferric uptake regulator (Fur) attenuates\u00a0<em>Helicobacter pylori\u00a0<\/em>J99 motility by disturbing the flagellar motor switch and autoinducer-2 production. Lee AY*,\u00a0<strong><u>Kao CY*<\/u><\/strong>, Wang YK, Lin SY, Lai TY, Sheu BS, Lo CJ,Wu JJ. (*equal contribution). Helicobacter. 2017 Aug;22(4). doi: 10.1111\/hel.12388. Epub 2017 Apr 12.\u00a0(SCI, IF: 4.3, Ranking: 34\/147 Gastroenterology &amp; Hepatology).<\/li>\n<li>Characterization of high exopolysaccharide-producing\u00a0<em>Lactobacillus\u00a0<\/em>strains isolated from mustard pickles for potential probiotic applications. Huang JY,\u00a0<strong><u>Kao CY<\/u><\/strong>, Liu WS, Fang TJ. Int Microbiol. 2017 Jun;20(2):75-84. doi: 10.2436\/20.1501.01.287.\u00a0(SCI, IF: 2.3, Ranking: 113\/177 Biotechnology and Applied Microbiology)<\/li>\n<li>Molecular Characterization of Antimicrobial Susceptibility of\u00a0<em>Salmonella<\/em>Isolates: First Identification of a Plasmid Carrying\u00a0<em>qnrD<\/em>\u00a0or\u00a0<em>oqxAB<\/em>\u00a0in Taiwan.\u00a0<strong><u>Kao CY*<\/u><\/strong>, Chen CA*, Liu YF, Wu HM,<sup>\u00a0<\/sup>Chiou CS,<sup>\u00a0<\/sup>Yan JJ,<sup>\u00a0<\/sup>Wu<sup>\u00a0<\/sup> (*equal contribution) J Microbiol Immunol Infect. 2017 Apr;50(2):214-223. doi: 10.1016\/j.jmii.2015.03.004. Epub 2015 May 14.\u00a0(SCI, IF: 3.7, Ranking: 35\/137 Infectious Diseases).<\/li>\n<li>Complete Genome Sequence of Carbapenem-Resistant\u00a0<em>Klebsiella pneumoniae<\/em>Strain 1756, Isolated from a Pus Specimen.\u00a0<strong><u>Kao CY<\/u><\/strong>,\u00a0Yan JJ, Lin YC, Zheng PX, Wu JJ. Genome Announc. 2017 Mar 30;5(13). pii: e00066-17. doi: 10.1128\/genomeA.00066-17.<\/li>\n<li>The\u00a0<em>Helicobacter pylori<\/em>J99\u00a0<em>jhp0106<\/em>\u00a0gene, under the Control of the CsrA\/RpoN Regulatory System, Modulates Flagella Formation and Motility.\u00a0<strong><u>Kao CY<\/u><\/strong>,\u00a0Chen<sup>\u00a0<\/sup>JW, Wang S, Sheu BS, Wu JJ. Front Microbiol. 2017 Mar 28;8:483. doi: 10.3389\/fmicb.2017.00483. eCollection 2017.\u00a0(SCI, IF: 4.5, Ranking: 38\/163 Microbiology).<\/li>\n<li>Orange Peel Fiber and\u00a0<em>Tremella flava<\/em>Chen Fermented Powder Effectively Induce Exopolysaccharide Production by\u00a0<em>Lactobacillus plantarum<\/em>\u00a0SLC 13. Huang JY, Huang ML,\u00a0<strong><u>Kao CY<\/u><\/strong>, Fang TJ. Int. J. Agric. Biol.\u00a02017. 19(3):437-444. doi: 10.17957\/IJAB\/15.0298. (SCI, IF: 0.822, Ranking: 38\/58 Agriculture, Multidisciplinary)<\/li>\n<\/ul>\n<p><strong>2016:<\/strong><\/p>\n<ul>\n<li>Molecular characterization of extended-spectrum \u03b2-lactamase-producing\u00a0<em>Escherichia coli<\/em>and\u00a0<em>Klebsiella<\/em> isolates in Mongolia.\u00a0<strong><u>Kao CY<\/u><\/strong>, Udval<sup>\u00a0<\/sup>U, Huang YT, Wu<sup>\u00a0<\/sup>HM, Huang<sup>\u00a0<\/sup>AH, Bolormaa<sup>\u00a0<\/sup>E, Yan<sup>\u00a0<\/sup>JJ, Urangoo Z, Batbaatar G, Khosbayar<sup>\u00a0<\/sup>T, Wu<sup>\u00a0<\/sup>JJ. J Microbiol Immunol Infect. 2016 Oct;49(5):692-700. doi: 10.1016\/j.jmii.2015.05.009.\u00a0(SCI, IF: 3.7, Ranking: 35\/137 Infectious Diseases).<\/li>\n<li>Plasmid-mediated quinolone resistance determinants in quinolone-resistant\u00a0<em>Escherichia coli<\/em>isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015.\u00a0<strong><u>Kao CY<\/u><\/strong>, Wu HM, Lin WH, Tseng CC, Yan<sup>\u00a0<\/sup>JJ, Wang MC, Teng CH, Wu<sup>\u00a0<\/sup> Sci Rep. 2016 Aug 30;6:32281. doi: 10.1038\/srep32281.\u00a0(SCI, IF: 3.9, Ranking: 25\/135 Multidisciplinary Sciences)<\/li>\n<li>Overproduction of active efflux pump and variations of OprD dominate in imipenem-resistant\u00a0<em>Pseudomonas aeruginosa<\/em>isolated from patients with bloodstream infection in Taiwan.\u00a0<strong><u>Kao CY*<\/u><\/strong>, Chen SS*, Hung<sup>\u00a0<\/sup>KH,<sup>\u00a0<\/sup>Wu<sup>\u00a0<\/sup>HM, Hsueh<sup>\u00a0<\/sup>PR, Yan<sup>\u00a0<\/sup>JJ, Wu<sup>\u00a0<\/sup> (*equal contribution) BMC Microbiol. 2016 Jun 13;16(1):107. doi: 10.1186\/s12866-016-0719-2.\u00a0(SCI, IF: 4.2, Ranking: 46\/163 Microbiology).<\/li>\n<li>An integrated microfluidic system for diagnosis of the resistance of Helicobacter pylori to quinolone-based antibiotics. Chao CY, Wang CH, Che YJ,\u00a0<strong><u>Kao CY<\/u><\/strong>, Wu JJ, Lee GB. Biosens Bioelectron. 2016 Apr 15;78:281-9. doi: 10.1016\/j.bios.2015.11.046. (SCI, IF: 10.5, Ranking: 3\/111 Chemistry, Analytical)<\/li>\n<li>First characterization of fluoroquinolone resistance mechanisms in CTX-M-producing\u00a0<em>Escherichia coli<\/em>from Mongolia.\u00a0<strong><u>Kao CY<\/u><\/strong>, Udval<sup>\u00a0<\/sup>U, Wu<sup>\u00a0<\/sup>HM, Bolormaa<sup>\u00a0<\/sup>E, Yan<sup>\u00a0<\/sup>JJ, Khosbayar<sup>\u00a0<\/sup>T, Wu<sup>\u00a0<\/sup> Infect Genet Evol. 2016 Mar;38:79-81. doi:10.1016\/j.meegid.2015.12.010.\u00a0(SCI, IF: 2.6, Ranking: 63\/137 Infectious Diseases).<\/li>\n<li><em>Helicobacter pylori\u00a0<\/em>Infection: An Overview of Bacterial Virulence Factors and Pathogenesis.\u00a0<strong><u>Kao CY<\/u><\/strong>, Sheu BS, Wu JJ. Biomed J. 2016 Feb;39(1):14-23. doi: 10.1016\/j.bj.2015.06.002. Epub 2016 Apr 1. (SCI, IF: 4.4, Ranking: 89\/319 Biochemistry &amp; Molecular biology)<\/li>\n<\/ul>\n<p><strong>2015:\u00a0<\/strong><\/p>\n<ul>\n<li>Intracellular Osteopontin Induced by CagA-positive\u00a0<em>Helicobacter pylori<\/em>Promotes Beta-catenin Accumulation and Interleukin-8 Secretion in Gastric Epithelial cells. Chang WL, Yang HB,<sup>\u00a0<\/sup>Cheng HC, Yeh YC,\u00a0<strong><u>Kao CY<\/u><\/strong>, Wu JJ, Lu CC, Sheu BS. Helicobacter. 2015 Dec;20(6):476-84. doi: 10.1111\/hel.12225. Epub 2015 Mar 3.\u00a0\u00a0(SCI, IF: 4.3, Ranking: 34\/147 Gastroenterology &amp; Hepatology).<\/li>\n<li>The Challenge of Fluoroquinolone Resistance: Epidemiology, Mechanisms, and Clinical impact.\u00a0<strong><u>Kao CY<\/u><\/strong>, Wu JJ. J Biomed Lab Sci. \u53f0\u7063\u751f\u6aa2\u96dc\u8a8c.2015 Sep;27(3):77-86.<\/li>\n<li>Carbapenem Resistance: Epidemiology, Mechanisms and Screening Methods.\u00a0<strong><u>Kao CY<\/u><\/strong>, Wu JJ. J Biomed Lab Sci. \u53f0\u7063\u751f\u6aa2\u96dc\u8a8c. 2015 Mar;27(1):1-9.<\/li>\n<li>Genome Sequence and Annotation of\u00a0<em>Helicobacter pylori<\/em>Strain Hp238 Isolated from a Taiwanese Patient with MALT Lymphoma.\u00a0<strong><u>Kao<sup>\u00a0<\/sup>CY<\/u><\/strong>, Chen<sup>\u00a0<\/sup>JW, Huang<sup>\u00a0<\/sup>YT, Sheu<sup>\u00a0<\/sup>SM, Sheu<sup>\u00a0<\/sup>BS, Wu JJ. Genome Announc. 2015 Feb 19;3(1). pii: e00006-15. doi: 10.1128\/genomeA.00006-15.<\/li>\n<\/ul>\n<p><strong>2014:\u00a0\u00a0<\/strong><\/p>\n<ul>\n<li>CsrA regulates\u00a0<em>Helicobacter pylori\u00a0<\/em>J99 motility and adhesion by controlling flagella formation.\u00a0<strong><u>Kao CY<\/u><\/strong>, SheuBS,<sup>\u00a0<\/sup>Wu JJ. Helicobacter. 2014 Dec;19(6):443-54. doi: 10.1111\/hel.12148.\u00a0(SCI, IF: 4.3, Ranking: 34\/147 Gastroenterology &amp; Hepatology).<\/li>\n<li>The Complex Interplay among Bacterial Motility and Virulence Factors in Different\u00a0<em>Escherichia coli<\/em><strong><u>Kao CY<\/u><\/strong>, Lin WH, Tseng CC, Wu AB, Cheng SW, Wang MC, Wu JJ.\u00a0 Eur J Clin Microbiol Infect Dis. 2014 Dec;33(12):2157-62. doi: 10.1007\/s10096-014-2171-2.\u00a0(SCI, IF: 3.0, Ranking:\u00a048\/137\u00a0Infectious Diseases)<\/li>\n<li>Dissemination of OXA-Carbapenemase-Producing\u00a0<em>Acinetobacter baumannii\u00a0<\/em>ST195 and ST642 in a Mongolian Hospital.\u00a0<strong><u>Kao CY<\/u><\/strong>, UdvalU, Oyunchimeg<sup>\u00a0<\/sup>R, Wu<sup>\u00a0<\/sup>HM, Huang<sup>\u00a0<\/sup>AH, Bolormaa<sup>\u00a0<\/sup>E, Munkhtuya<sup>\u00a0<\/sup>E, Yan<sup>\u00a0<\/sup>JJ, Batbaatar<sup>\u00a0<\/sup>G, Khosbayar<sup>\u00a0<\/sup>T, Wu<sup>\u00a0<\/sup> Infect Genet Evol. 2014 Dec;28:313-6. doi: 10.1016\/j.meegid.2014.10.024.\u00a0(SCI, IF: 2.6, Ranking: 63\/137 Infectious Diseases).<\/li>\n<li>Higher glucose level can enhance the<em> pylori<\/em>adhesion and virulence related with type IV secretion system in AGS cells. Sheu SM, Cheng H,\u00a0<strong>Kao CY<\/strong>, Yang YJ, Wu JJ, Sheu BS. J Biomed Sci. 2014 Oct 9;21(1):96. doi:10.1186\/s12929-014-0096-9.\u00a0(SCI, IF: 12,1, Ranking: 9\/195 Medicine, Research, &amp; Experimental)<\/li>\n<li>Clinical and microbiologic characteristics of\u00a0<em>Klebsiella pneumonia\u00a0<\/em>from community-acquired recurrent urinary tract infections. Lin WH,\u00a0<strong><u>Kao CY<\/u><\/strong>, Yang DC, Tseng CC. Wu AB, Teng CH, Wang MC, Wu JJ. Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1533-9. doi: 10.1007\/s10096-014-2100-4.\u00a0(SCI, IF: 3.0, Ranking: 48\/137 Infectious Diseases).<\/li>\n<li>First Report of the Prevalence of Extended-Spectrum \u03b2-Lactamase Producing\u00a0<em>Escherichia coli<\/em>in Two Mongolian Hospitals.\u00a0<strong><u>Kao CY*<\/u><\/strong>, Udval U*, Wu HM, Bolormaa E, Yan JJ, Khosbayar T, Wu JJ. (*equal contribution) Infect Genet Evol. 2014 Jul;25:66-8. doi: 10.1016\/j.meegid.2014.04.012.\u00a0\u00a0(SCI, IF: 2.6, Ranking: 63\/137 Infectious Diseases).<\/li>\n<li>Heteroresistance of\u00a0<em>Helicobacter pylori\u00a0<\/em>from the same patient prior to antibiotic treatment.\u00a0<strong><u>Kao CY<\/u><\/strong>, Lee AY, Huang AH, Song PI, Yang YJ, Sheu SM, Chang WL, Sheu BS, Wu JJ. Infect Genet Evol. 2014 Apr;23:196-202. doi: 10.1016\/j.meegid.2014.02.009.\u00a0(SCI, IF: 2.6, Ranking: 63\/137 Infectious Diseases).<\/li>\n<\/ul>\n<p><strong>\u00a02012:<\/strong><\/p>\n<ul>\n<li>Higher motility enhances bacterial density and inflammatory response in dyspeptic patients infected with\u00a0<em>Helicobacter pylori<\/em>.\u00a0<strong><u>Kao CY<\/u><\/strong>, Sheu BS, Sheu SM, Yang HB, Chang WL, Cheng HC, Wu JJ. Helicobacter. 2012 Dec;17(6):411-6. doi: 10.1111\/j.1523-5378.2012.00974.x.\u00a0(SCI, IF: 4.3, Ranking: 34\/147 Gastroenterology &amp; Hepatology).<\/li>\n<li>Gemifloxacin can partially overcome quinolone resistance of\u00a0<em> pylori<\/em>with\u00a0<em>gyrA<\/em>\u00a0mutation in Taiwan. Chang WL,\u00a0<strong><u>Kao CY<\/u><\/strong>, Wu CT, Huang AH, Wu JJ, Yang HB, Cheng HC, Sheu BS. Helicobacter. 2012 Jun;17(3):210-5. doi: 10.1111\/j.1523-5378.2012.00935.x.\u00a0(SCI, IF: 4.3, Ranking: 34\/147 Gastroenterology &amp; Hepatology).<\/li>\n<li>Length of thymidine homopolymeric repeats modulates promoter activity of\u00a0<em>sabA<\/em>in\u00a0<em>Helicobacter pylori<\/em>.\u00a0<strong><u>Kao CY<\/u><\/strong>, Sheu SM, Sheu BS, Wu JJ. Helicobacter. 2012 Jun;17(3):203-9. doi: 10.1111\/j.1523-5378.2012.00936.x.\u00a0(SCI, IF: 4.3, Ranking: 34\/147 Gastroenterology &amp; Hepatology).<\/li>\n<li><em> pylori<\/em>clinical isolates have diverse\u00a0<em>babAB<\/em>\u00a0genotype distributions over different topographic sites of stomach with correlation to clinical disease outcomes. Sheu SM, Sheu BS, Chiang WC,\u00a0<strong><u>Kao CY<\/u><\/strong>, Wu HM, Yang HB, Wu JJ. BMC Microbiol. 2012 May 30;12:89. doi: 10.1186\/1471-2180-12-89.\u00a0(SCI, IF: 4.2, Ranking: 46\/163 Microbiology).<\/li>\n<\/ul>\n<h2><strong>Research Projects<\/strong><\/h2>\n<ul>\n<li>2025\/08-2026\/07.\u00a0Co-Principal investigator.\u00a0National Science and Technology Council.\u00a0Title:\u00a0Investigate the impact of the microbiota and metabolism on MASLDHCC and develop probiotics or post-biotics with the potential to improve and prevent MASLD-HCC.\u00a0Grant number: NSTC\u00a0114-2314-B-A49-088-.<\/li>\n<li>2025\/08-2026\/07.\u00a0Co-Principal investigator.\u00a0National Science and Technology Council.\u00a0Title:\u00a0Investigation into the evolution of carbapenem-resistant\u00a0<em>Escherichia coli\u00a0<\/em>within the host and its association with recurrent and multi-site infections.\u00a0Grant number:\u00a0NSTC 114-2635-B-385-001-.<\/li>\n<li>2025\/05-2026\/04.\u00a0Co-Principal investigator. National Science and Technology Council.\u00a0Title:\u00a0Establishment of research collaboration and technical service for national human microbiome core facilities. Grant number: NSTC\u00a0114-2740-B-A49-003-.<\/li>\n<li>2025\/05-2026\/04. Co-Principal investigator. National Science and Technology Council. Title: The study of\u00a0<em>Akkermansia muciniphila<\/em>and related metabolites as a biomarker or an adjuvant therapy for hepatocellular carcinoma\u00a0(II). Grant number: NSTC 114-2321-B-A49-004-.<\/li>\n<li>2025\/01-2025\/12.\u00a0\u00a0Principal investigator.\u00a0KMU-NYCU joint grant. Exploring the metabolites of probiotics isolated from Taiwanese to evaluate their potential future.\u00a0Grant number: NYCUKMU-114-I004.<\/li>\n<li>2025\/01-2025\/12.\u00a0Co-Principal investigator. Taipei City Hospital.\u00a0Investigation of the role of gut microbiota in patients with primary premature ejaculation disorder and its effect on dapoxetine response.\u00a0Grant number:\u00a0TBD.<\/li>\n<li>2025\/01-2025\/12.\u00a0Principal investigator.Industry-academia collaboration grant. Title:\u00a0\u00a0Drug testing using an interstitial cystitis rat model.\u00a0Grant number:\u00a0114A140063.<\/li>\n<li>2025\/01-2025\/12.\u00a0Principal investigator.\u00a0CGMH-NYCU Joint Research Program. Title:\u00a0Exploring the potential of low-energy shock waves and bacteriophages in the treatment of recurrent urinary tract infections (II):\u00a0<em>In vivo<\/em>Grant number:\u00a0114W094004.<\/li>\n<li>2025\/01-2025\/12.\u00a0Co-Principal investigator. Taipei\u00a0Tzu Chi Hospital\u00a0research grant. Title:\u00a0Study alternative mechanisms of Staphylococcus lugdunensis against lugdunin.\u00a0Grant number:\u00a0TBD.<\/li>\n<li>2025\/01-2025\/12.\u00a0Co-Principal investigator.\u00a0Taipei Veterans General Hospital research grant. Title:\u00a0Role of urinary microbiome in kidney calcium oxalate stone formation.\u00a0Grant number:\u00a0TBD.<\/li>\n<li>2025\/01-2025\/12.\u00a0Co-Principal investigator.\u00a0Taipei Veterans General Hospital research grant. Title:\u00a0Characterization of plasmids carrying carbapenemase genes in carbapenem-resistant\u00a0<em>Klebsiella pneumoniae<\/em>and\u00a0<em>Escherichia coli<\/em>\u00a0isolated from urinary tract infection and bacteremia patients.\u00a0Grant number:\u00a0V114C-075.<\/li>\n<li>2025\/01-2025\/12.\u00a0Co-Principal investigator.\u00a0Taoyuan General Hospital\u00a0research grant\u00a0(Ministry of Health and Welfare). Title:\u00a0Investigation of the effects of carbapenemase-siderophore-carrying plasmids from\u00a0<em>Escherichia coli<\/em>and\u00a0<em>Klebsiella pneumoniae<\/em>\u00a0on bacterial antimicrobial resistance and virulence.\u00a0Grant number:\u00a0PTH114126.<\/li>\n<li>2025\/01-2025\/12.\u00a0Co-Principal investigator.\u00a0Taoyuan General Hospital\u00a0research grant\u00a0(Ministry of Health and Welfare). Title: Investigation of the antibiotic resistance, virulence-associated genes, and phenotypes among different species within the\u00a0<em>Klebsiella pneumoniae<\/em>species complex. Grant number: PTH-114012.<\/li>\n<li>2025\/01-2025\/12.\u00a0Co-Principal investigator.\u00a0National Taiwan University\u00a0Hospital research grant (Hsin-Chu branch). Title:\u00a0Exploring the characteristics of hypervirulent and carbapenem-resistant Pseudomonas aeruginosa (I): phenotypic and genotypic analysis.\u00a0Grant number:\u00a0114-HCH064.<\/li>\n<li>2024\/12.\u00a0Principal investigator.Ministry of Science and Technology Research Promotion Center for Life Sciences. 2024\u00a0Taiwan Society for Microbiology Annual conference.<\/li>\n<li>2024\/08-2028\/07.\u00a0Principal investigator.Industry-academia collaboration grant\u00a0(Biomedical Industry Ph.D. Program, NYCU). Title:\u00a0 Development of next-generation probiotic products with enhanced metabolic disease improvement efficiency. Grant number:\u00a0113A140106.<\/li>\n<li>2024\/08-2025\/07.\u00a0Co-Principal investigator. En Chu Kong Hospital research grant. Title:\u00a0Investigation of the evolution of carbapenem-resistant\u00a0<em>Escherichia coli<\/em>in the host and its association with recurrent infections (second year).\u00a0Grant number: ECKH_W11303.<\/li>\n<li>2024\/08-2027\/07. Principal investigator.\u00a0National Science and Technology Council (Excellent Young Scholars Fund).\u00a0Title:\u00a0Development of novel indolenine-substituted pyrazole small molecules to combat multidrug-resistant staphylococcal infections and investigation of their antibacterial and anti-biofilm mechanisms.\u00a0Grant number:\u00a0113-2628-B-A49-011-MY3.<\/li>\n<li>2024\/08-2025\/07.\u00a0Co-Principal investigator. National Science and Technology Council. Title:\u00a0Combating Carbapenem Resistance in\u00a0<em>Klebsiella pneumoniae<\/em>Complex and\u00a0<em>Enterobacteriaceae\u00a0<\/em>Complex: Taiwan&#8217;s Diverse Strategies.\u00a0Grant number:\u00a0113-2314-B-002-129-.<\/li>\n<li>2024\/08-2025\/07.\u00a0Co-Principal investigator. National Science and Technology Council. Title: Investigation of the anti-lugunin mechanism of\u00a0<em>Staphylococcus lugdununsis<\/em>.\u00a0Grant number: 113-2320-B-182A-014-.<\/li>\n<li>2024\/06-2025\/02. Principal investigator. Ministry of Education. Title: The New Southbound Policy: Overseas Internship Program. Grant number: 113005400N02.<\/li>\n<li>2024\/05-2025\/04.\u00a0Co-Principal investigator. National Science and Technology Council.\u00a0Title:\u00a0Establishment of research collaboration and technical service for national human microbiome core facilities. Grant number: NSTC\u00a0113-2740-B-A49-003-.<\/li>\n<li>2024\/05-2025\/04. Co-Principal investigator. National Science and Technology Council. Title: The study of\u00a0<em>Akkermansia muciniphila<\/em>and related metabolites as a biomarker or an adjuvant therapy for hepatocellular carcinoma (I). Grant number: NSTC 113-2321-B-A49-014-.<\/li>\n<li>2024\/01-2024\/12.\u00a0The Higher Education Sprout Project of the National Yang Ming Chiao Tung University and Ministry of Education (MOE), Taiwan.<\/li>\n<li>2024\/01-2024\/12.\u00a0Principal investigator.\u00a0CGMH-NYCU Joint Research Program. Title:\u00a0Exploring the potential of low energy shock waves and bacteriophages in the treatment of recurrent urinary tract infections (I):\u00a0<em>In vitro<\/em>Grant number:\u00a0CGMH-NYCU-113-CORPG8P0211.<\/li>\n<li>2024\/01-2024\/12.\u00a0Co-Principal investigator.\u00a0National Taiwan University\u00a0Hospital research grant (Hsin-Chu branch). Title:\u00a0Isolation and characterization of lytic bacteriophages targeting carbapenem-resistant\u00a0<em>Enterobacter<\/em>Grant number:\u00a0113-HCH057.<\/li>\n<li>2024\/01-2024\/12.\u00a0Co-Principal investigator.\u00a0Research Project of Shin Kong Wu Ho-Su Memorial Hospital. Title:\u00a0Screening and investigation of antibacterial and antivirulence botanical compounds.\u00a0Grant number:\u00a02024SKHAND011.<\/li>\n<li>2024\/01-2024\/12.\u00a0Co-Principal investigator.\u00a0Research Project of\u00a0Shin Kong Wu Ho-Su Memorial Hospital. Title:\u00a0Investigation of the\u00a0<em>in vitro<\/em>evolution of\u00a0<em>Acinetobacter baumannii\u00a0<\/em>under carbapenem-selected stress.\u00a0Grant number:\u00a02024SKHAND009.<\/li>\n<li>2024\/01-2024\/12.\u00a0Co-Principal investigator.\u00a0Taipei Veterans General Hospital research grant. Title:\u00a0To investigate the evolution of pathogen within host and its pathogenesis of recurrent urinary tract infection (II).\u00a0Grant number: V113C-200.<\/li>\n<li>2024\/01-2024\/12.\u00a0Co-Principal investigator.\u00a0Taipei Veterans General Hospital research grant. Title:\u00a0The change of saliva microbiota after interventional sialendoscopy in sialolithiasis patients.\u00a0Grant number: V113C-192.<\/li>\n<li>2024\/01-2024\/12.\u00a0Principal investigator.\u00a0Yen Tjing Ling Medical Foundation, Taiwan.\u00a0Title:\u00a0Characterization of colistin resistance mechanisms in colistin-nonsusceptible\u00a0<em> pneumoniae\u00a0<\/em>and the role(s) of\u00a0<em>mcr<\/em>-carrying plasmids in its pathogenesis.\u00a0Grant number: CI-113-29.<\/li>\n<li>2023\/12-2024\/11.\u00a0Principal investigator.Company industry-academia collaboration grant.\u00a0Title:\u00a0Isolation, characterization, and product development of probiotics with potential applications (I). Grant number: 112A40114Y.<\/li>\n<li>2023\/10-2024\/09.\u00a0Principal investigator.Company industry-academia collaboration grant. Title:\u00a0Isolation and characteristics of probiotics\u00a0with potential applications for\u00a0improving the gastrointestinal health of animals (I).\u00a0Grant number:\u00a0\u00a0112A40105Y.<\/li>\n<li>2023\/10-2025\/12.\u00a0The Higher Education Sprout Project of the National Yang Ming Chiao Tung University and Ministry of Education (MOE), Taiwan.<\/li>\n<li>2023\/08-2024\/07.\u00a0Co-Principal investigator. National Science and Technology Council. Title:\u00a0Multi-faceted analysis of the evolution and drug resistance of endemic uropathogens: a 24-year longitudinal research from a Southern Taiwan Medical Center.\u00a0Grant number:\u00a0112-2314-B-006-060-.<\/li>\n<li>2023\/08-2026\/07. Principal investigator.\u00a0National Science and Technology Council.\u00a0Title: Multi-faceted analysis of the evolution of Escherichia coli within-host and its interaction with microbiota to explore the mechanisms of recurrent urinary tract infections.\u00a0Grant number:\u00a0112-2320-B-A49-045-MY3.<\/li>\n<li>2023\/08-2026\/07.\u00a0Co-Principal investigator. National Science and Technology Council.\u00a0Title:\u00a0Effects of Low Energy Shock Waves on urinary tract bacteria-\u00a0<em>in vitro<\/em>and in experimental cystitis model in rats. Grant number: NSTC 112-2314-B-182A-135-MY3.<\/li>\n<li>2023\/08-2024\/07.\u00a0Co-Principal investigator. En Chu Kong Hospital research grant. Title:\u00a0Investigation of the evolution of carbapenem-resistant Escherichia coli in the host and its association with recurrent infections.\u00a0Grant number: ECKH_W11201.<\/li>\n<li>2023\/06-2023\/09.\u00a0Principal investigator.\u00a0Ministry of Education. Title: The New Southbound Policy: Overseas Internship Program.\u00a0Grant number: 111005400N01.<\/li>\n<li>2023\/05-2024\/04.\u00a0Co-Principal investigator. National Science and Technology Council.\u00a0Title:\u00a0Establishment of research collaboration and technical service for national human microbiome core facilities.\u00a0Grant number:\u00a0NSTC\u00a0112-2740-B-A49-002-.<\/li>\n<li>2023\/03-2024\/02.\u00a0Principal investigator.Company industry-academia collaboration grant. Title: Isolation and characterization of probiotics with potential applications for the prevention of vaginal infections (I). Grant number:\u00a0 112A40071Y.<\/li>\n<li>2023\/03-2024\/02.\u00a0Co-Principal investigator.\u00a0Chang Gung Medical Foundation CMRP grant.\u00a0Title:\u00a0Characterization of lugdunin activity produced by\u00a0<em>Staphylococcus lugdunensis<\/em>isolates from 2003-2020 in Chang Gung Memorial Hospital: epidemiology, antibacterial activity, association with different genotypes, and gene regulation. Grant number: CMRPG3N0091.<\/li>\n<li>2023\/01-2023\/12.\u00a0Co-Principal investigator.\u00a0Taipei Veterans General Hospital research grant. Title:\u00a0\u00a0Investigation of within-host bacterial evolution and pathogenesis in polymicrobial urinary tract infections.\u00a0Grant number:\u00a0V112C-203.<\/li>\n<li>2023\/01-2023\/12.\u00a0Principal investigator.\u00a0Yen Tjing Ling Medical Foundation, Taiwan.\u00a0Title:\u00a0Characterization of uropathogenic Escherichia coli in different phylogenetic groups.\u00a0Grant number:\u00a0CI-112-19.<\/li>\n<li>2023\/01-2023\/12.\u00a0Co-Principal investigator.\u00a0Taipei Veterans General Hospital\u00a0research grant. Title:\u00a0To investigate the evolution of pathogen within host and its pathogenesis of recurrent urinary tract infection.\u00a0Grant number: V112C-208.<\/li>\n<li>2022\/08-2025\/07. Co-Principal investigator. National Science and Technology Council. Title:\u00a0The effects of testicular microenvironment on spermatogenesis in men with non-obstructive azoospermia &#8211; Analysis of testicular steroidogenesis patterns and metaproteomics of testicular bacteria microbiome.\u00a0Grant number: MOST 111-2314-B-075-044-MY3.<\/li>\n<li>2022\/08-2023\/07. Co-Principal investigator. En Chu Kong Hospital research grant. Title:\u00a0Investigation of the phenotypic and genomic evolution of carbapenem-resistant\u00a0<em>Escherichia coli<\/em>in the host.\u00a0Grant number: ECKH_W11105.<\/li>\n<li>2022\/08-2023\/07.\u00a0Co-Principal investigator.\u00a0Chang Gung Medical Foundation CMRP grant.\u00a0Title:\u00a0Characterization of an endemic\u00a0<em>Staphylococcus lugdunensis\u00a0<\/em>type 6 in a\u00a0 medical center.\u00a0Grant number: CMRPG3M1041.<\/li>\n<li>2022\/08.\u00a0Principal investigator.Ministry of Science and Technology Research Promotion Center for Life Sciences. 2022 26th bacteriology conference.<\/li>\n<li>2022\/06-2022\/05.\u00a0Principal investigator.BXB\u00a0company industry-academia collaboration grant. Title:\u00a0Isolation and characterization of probiotics with potential applications. Grant number:\u00a0TBC<\/li>\n<li>2021\/10-2022\/09.\u00a0Principal investigator.BENED Biomedical company industry-academia collaboration grant. Title: The role(s) of probiotics on anti-<em>Helicobacter pylori<\/em>\u00a0activity and its mechanisms (II). Grant number: YM110J063.<\/li>\n<li>2021\/08-2022\/07.\u00a0Principal investigator.Ministry of Science and Technology, Republic of China, Taiwan. Title: Investigate the evolution of\u00a0<em>Escherichia coli<\/em>\u00a0within host and its pathogenesis of recurrent urinary tract infection. Grant number: 110-2320-B-A49A-524-.<\/li>\n<li>2021\/08-2022\/07.\u00a0Co-Principal investigator.\u00a0Chang Gung Medical Foundation CMRP grant.\u00a0Title: Determination of the association of CRISPR-Cas system with oxacillin susceptibility, MLST sequence types,\u00a0and virulence in\u00a0<em>Staphylococcus lugdunensis<\/em>. Grant number: CMRPG3L0631.<\/li>\n<li>2021\/01-2021\/12. Principal investigator. National Yang-Ming University-Far Eastern Memorial Hospital Joint Research Program, Taiwan.\u00a0Title: Characterization of carbapenem-non-susceptible\u00a0<em>Acinetobacter<\/em>isolated from patients with bloodstream infection.\u00a0Grant number: 110DN14.<\/li>\n<li>2021\/01-2021\/12. Principal investigator. Yen Tjing Ling Medical Foundation, Taiwan.\u00a0Title: Characterization of\u00a0<em> coli<\/em>isolated from patients with recurrent urinary tract infections.\u00a0Grant number: CI-110-13.<\/li>\n<li>2020\/10-2021\/10. Principal investigator. Ministry of Science and Technology, Republic of China, Taiwan.\u00a0Title: Increasing the international visibility of Taiwan society of microbiology.\u00a0Grant number: 109-2926-I-010-505.<\/li>\n<li>2020\/10-2021\/09. Co-Principal investigator.\u00a0Chang Gung Medical Foundation CMRP grant. Title: Determination of oxacillin susceptibility and SCC<em>mec<\/em>structure of predominant sequence type 3, 6, and 27\u00a0<em>Staphylococcus lugdunensis\u00a0<\/em>in Taiwan.\u00a0Grant number: CMRPG3K1421.<\/li>\n<li>2020\/08-2021\/07. Principal investigator. BENED Biomedical company industry-academia collaboration grant.\u00a0Title: The\u00a0role(s)\u00a0of probiotics on anti-<em>Helicobacter pylori<\/em>activity and its mechanisms.\u00a0Grant number: YM109C036.<\/li>\n<li>2020\/08-2022\/07. Co-Principal investigator. En Chu Kong Hospital research grant.\u00a0\u00a0Title: Molecular characterization of carbapenem-resistant\u00a0<em>Enterobacteriaceae<\/em>in a regional teaching hospital in Taiwan, 2011-2019.\u00a0Grant number: ECKH_W10901 &amp; ECKH_W11001.<\/li>\n<li>2020\/08-2023\/07.\u00a0Principal investigator.\u00a0Ministry of Science and Technology, Taiwan. Title: Characterization of the role(s) of PASTA kinase-mediated signaling pathways in resistance of Staphylococcus aureus to \u03b2-lactam antibiotics. Grant number: 109-2320-B-010 -036 -MY3.<\/li>\n<li>2019\/10-2020\/10.\u00a0Principal investigator.\u00a0Ministry of Science and Technology, Taiwan. Title: Connect American and Taiwan societies for microbiology to promote the international visibility of microbiology research in Taiwan . Grant number:108-2911-I-010-508.<\/li>\n<li>2017\/10-2019\/10.\u00a0Principal investigator.\u00a0Postdoctoral Research Abroad Program, Ministry of Science and Technology, Taiwan. Title: Characterization of Listeria monocytogenes CFPTS gene cluster in central nervous systemic infection. Grant number: 106-2917-I-564-070.<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<section class=\"av_textblock_section av-wxancv-a67709c652ba842916b53b07686485fa\">\n<div class=\"avia_textblock\"><\/div>\n<\/section>\n<\/div>\n<\/div>\n<div id=\"tab_laboratory-overview\" class=\"panel entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-laboratory-overview\">\n<h2><strong>Research Focus<\/strong><\/h2>\n<p><img width=\"1280\" height=\"853\"\ndecoding=\"async\"\nclass=\"alignnone size-full wp-image-587\"\nsrc=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1.jpg\"\nalt=\"\u7814\u7a76\u65b9\u5411\u793a\u610f\u5716\"\nwidth=\"1280\"\nheight=\"853\"\nsrcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1.jpg 1280w,\nhttps:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1-300x200.jpg 300w,\nhttps:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1-1024x682.jpg 1024w,\nhttps:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1-768x512.jpg 768w\"\nsizes=\"(max-width: 1280px) 100vw, 1280px\" srcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1.jpg 1280w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1-300x200.jpg 300w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1-1024x682.jpg 1024w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image001-1-768x512.jpg 768w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/><\/p>\n<p>\u6211\u5011\u81f4\u529b\u65bc\u4e86\u89e3\u7d30\u83cc\u7684\u81f4\u75c5\u6a5f\u8f49\u3001\u6297\u751f\u7d20\u6297\u85e5\u6027\u3001\u83cc\u76f8\u4f5c\u7528\u8207\u85e5\u7269\u958b\u767c\u3002\u7814\u7a76\u4e3b\u8981\u805a\u7126\u65bc\u4e09\u5927\u9818\u57df\uff1a\u7d30\u83cc\u81f4\u75c5\u6a5f\u5236\u7684\u57fa\u790e\u7814\u7a76\u3001\u6297\u751f\u7d20\u6297\u85e5\u6027\u6a5f\u5236\uff0c\u4ee5\u53ca\u61c9\u7528\u5fae\u751f\u7269\u5b78\uff0c\u7279\u5225\u662f\u5c0f\u5206\u5b50\u6cbb\u7642\u85e5\u7269\u7684\u958b\u767c\u3002\u4ee5\u4e0b\u662f\u6211\u5011\u65bc\u904e\u53bb\u4e94\u5e74\uff082020\u20132025\u5e74\uff09\u5728\u9019\u4e9b\u9818\u57df\u4e2d\u7684\u7814\u7a76\u6210\u679c\u7e3d\u7d50\uff1a<\/p>\n<p>\u4e00\u3001\u57fa\u790e\u7814\u7a76: \u81ea2020\u5e74\u81f32025\u5e74\uff0c\u6211\u7684\u7814\u7a76\u805a\u7126\u65bc\u591a\u7a2e\u4eba\u985e\u75c5\u539f\u83cc\u7684\u751f\u7406\u8207\u81f4\u75c5\u6a5f\u5236\uff0c\u7279\u5225\u8457\u91cd\u65bc\u57fa\u56e0\u8abf\u63a7\u8207\u4ee3\u8b1d\u9014\u5f91\u3002\u5728\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\uff08<em>Helicobacter pylori<\/em>\uff09\u4e2d\uff0c\u6211\u5011\u63ed\u793a\u4e86CsrA\u5982\u4f55\u5354\u8abf\u97ad\u6bdb\u7d44\u88dd\u8207\u5bbf\u4e3b\u4e92\u4f5c\u3002\u6211\u5011\u9032\u4e00\u6b65\u767c\u73fe\u53d7CsrA\u8abf\u63a7\u7684Jhp0106\u53ef\u80fd\u70ba\u4e00\u7a2e\u53c3\u8207\u97ad\u6bdb\u5f62\u6210\u8207\u83cc\u9ad4\u5b9a\u6b96\u7684\u91a3\u57fa\u8f49\u79fb\u9176\uff08Helicobacter. 2021 Apr;26(2):e12787\uff09\u3002\u900f\u904e\u751f\u7269\u8cc7\u8a0a\u5206\u6790\uff0c\u6211\u5011\u4e5f\u9451\u5b9a\u51faJhp0417\u8207Jhp0106\u53ef\u80fd\u7686\u53c3\u8207\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u7684\u97ad\u6bdb\u751f\u5408\u6210\u3002\u6211\u5011\u63a5\u8457\u5229\u7528TRIzol\u3001\u7532\u9187\u8207MTBE\u7b49\u8403\u53d6\u65b9\u6cd5\u9032\u884cuntargeted metabolomics\u8207lipidomics\uff0c\u5206\u6790<em>jhp0417<\/em>\u7a81\u8b8a\u682a\u8207\u91ce\u751f\u578b\u83cc\u682a\uff0c\u7d50\u679c\u986f\u793aTRIzol\u53ef\u6709\u6548\u81ea\u55ae\u4e00\u6a23\u672c\u4e2d\u540c\u6642\u8403\u53d6\u4ee3\u8b1d\u7269\u8207\u8102\u8cea\uff08Talanta. 2023 Jun 1;258:124416\uff09\u3002\u76ee\u524d\u6211\u5011\u6b63\u6df1\u5165\u6b64\u7814\u7a76\uff0c\u900f\u904e\u591a\u9ad4\u5b78\u6df1\u5165\u63a2\u8a0eCsrA\u8abf\u63a7\u7db2\u7d61\u6a5f\u5236\u3002\u7e3d\u7d50\u4f86\u8aaa\uff0c\u9019\u4e9b\u7814\u7a76\u6709\u52a9\u65bc\u52a0\u5f37\u6211\u5011\u5c0d\u7d30\u83cc\u81f4\u75c5\u6a5f\u8f49\u7684\u4e86\u89e3\uff0c\u4e26\u70ba\u672a\u4f86\u6cbb\u7642\u7b56\u7565\u63d0\u4f9b\u6f5b\u5728\u7814\u7a76\u76ee\u6a19\u3002<\/p>\n<p>\u4e8c\u3001\u6297\u751f\u7d20\u6297\u85e5\u6027\u7814\u7a76: \u6211\u7684\u6297\u85e5\u6027\u7814\u7a76\u6574\u5408\u4e86\u8a3a\u65b7\u6280\u8853\u958b\u767c\u3001\u6297\u85e5\u6027\u57fa\u56e0\u76e3\u6e2c\uff0c\u4ee5\u53ca\u53ef\u79fb\u52d5\u907a\u50b3\u6838\u9178\u7247\u6bb5\u7684\u8ffd\u8e64\u3002\u6211\u5011\u9a57\u8b49\u4e86mCIM\u8207eCIM\u6aa2\u6e2ccarbapenemase\u7684\u6e96\u78ba\u6027\uff0c\u4e26\u6307\u51fa\u591a\u7a2ecarbapenemase\u5171\u651c\u5e36\u6642\u53ef\u80fd\u5f71\u97ff\u6aa2\u6e2c\u8868\u73fe\uff08BMC Microbiol. 2020 Oct 17;20(1):315\uff09\u3002\u5c0d\u65bc<em>Staphylococcus lugdunensis<\/em>\uff0c\u57f9\u990a\u7a00\u91cb\u6cd5\u6bd4\u5176\u4ed6\u65b9\u6cd5\u66f4\u80fd\u6e96\u78ba\u8a55\u4f30\u5176\u5c0doxacillin\u7684\u654f\u611f\u6027\uff08J Microbiol Immunol Infect. 2022 Apr;55(2):234-240\uff09\u3002\u57fa\u56e0\u9ad4\u6d41\u884c\u75c5\u5b78\u7814\u7a76\u986f\u793a\uff0c\u591a\u91cd\u6297\u85e5\u6027\u7684\u5927\u8178\u687f\u83cc\u3001\u514b\u96f7\u4f2f\u6c0f\u80ba\u708e\u83cc\u3001\u8207\u9b91\u6c0f\u4e0d\u52d5\u687f\u83cc\u5ee3\u6cdb\u651c\u5e36carbapenemase\u3001<em>mcr<\/em>\u8207<em>qnr<\/em>\u7b49\u6297\u85e5\u57fa\u56e0\uff08Front Microbiol. 2022 Mar 11;13:703113\uff1bJ Glob Antimicrob Resist. 2022 Sep;30:241-248\uff1bEpidemiol Infect. 2023 Sep 7;151:e155\uff1bJ Infect Public Health. 2024 Mar;17(3):457-463\uff1bJ Microbiol Immunol Infect. 2024 Apr;57(2):288-299\uff1bMicrobiol Spectr. 2024 Jun 4;12(6):e0038224\uff1bJ Infect Public Health. 2024 Dec;17(12):102588\uff1bInt J Antimicrob Agents. 2025 Aug;66(2):107515\uff09\u3002\u9019\u4e9b\u6297\u85e5\u57fa\u56e0\u4e5f\u5e38\u4f4d\u65bc\u80fd\u63d0\u5347\u7d30\u83cc\u81f4\u75c5\u529b\u7684\u8cea\u9ad4\u4e0a\uff0c\u6211\u5011\u5df2\u8b49\u5be6\u900f\u904e\u8cea\u9ad4\u8f49\u79fb\u5f8c\uff0c\u7d30\u83cc\u5c0d<em>Galleria mellonella<\/em>\u7684\u81f4\u75c5\u529b\u986f\u8457\u4e0a\u5347\uff08BMC Microbiol. 2022 Jun 6;22(1):150\uff1bInfect Genet Evol. 2023 Jun;110:105420\uff09\u3002\u6b64\u5916\uff0c\u6211\u5011\u767c\u73fe\u5f9e\u5e74\u9577\u75c5\u4eba\u5206\u96e2\u7684\u5927\u8178\u687f\u83cc\u682a\uff0c\u5176\u6297\u85e5\u6027\u666e\u904d\u9ad8\u65bc\u5152\u7ae5\u6216\u5e74\u8f15\u6210\u4eba\u7684\u83cc\u682a\uff08J Microbiol Immunol Infect. 2022 Apr;55(2):249-256\uff09\uff0c\u800c\u4e14\u5927\u8178\u687f\u83cc\u4e0d\u540c\u7684phylogroup\u5176\u81f4\u75c5\u6027\u4e5f\u6709\u6240\u5dee\u7570\uff0c\u5176\u4e2dB2\u7fa4\u83cc\u682a\u8f03\u5177\u81f4\u75c5\u6027\uff08Infect Genet Evol. 2023 Oct;114:105493\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd1\u534a\u6578\u53cd\u8986\u6027\u6ccc\u5c3f\u9053\u611f\u67d3\u75c5\u4eba\u611f\u67d3\u7684\u662f\u540c\u4e00clone\uff0c\u6211\u5011\u76ee\u524d\u6b63\u91dd\u5c0d\u5bbf\u4e3b\u9ad4\u5167\u7684\u83cc\u682a\u6f14\u5316\u8207\u81f4\u75c5\u6027\u8b8a\u5316\u9032\u884c\u7814\u7a76\uff08BMC Microbiol. 2023 Mar 30;23(1):90\uff1bGut Pathogens, In revision\uff09\u3002\u5728<em>S. lugdunensis<\/em>\u4e2d\uff0c\u6211\u5011\u63a2\u8a0e\u4e86CRISPR-Cas\u7cfb\u7d71\u985e\u578b\u8207\u6297\u85e5\u6027\u3001\u5e8f\u5217\u578b\u8207lugdunin\u7522\u91cf\u4e4b\u9593\u7684\u95dc\u806f\uff0c\u53cd\u6620\u51fa\u6297\u85e5\u6027\u8207\u7d30\u83cc\u9632\u79a6\u6a5f\u5236\u9593\u7684\u8907\u96dc\u4e92\u52d5\uff08Microbiol Spectr. 2021 Dec 22;9(3):e0124721\uff1bJ Microbiol Immunol Infect. 2023 Apr;56(2):292-298\uff1bMicrobiol Spectr. 2023 Sep 21;11(5):e0129823\uff1bJ Microbiol Immunol Infect. 2024 Apr;57(2):278-287\uff09\u3002\u6700\u8fd1\uff0c\u6211\u5011\u805a\u7126\u65bc\u5177\u9ad8\u5ea6\u6bd2\u529b\u8207\u6975\u5ea6\u6297\u85e5\u6027\u7684\u83cc\u682a\u3002\u7814\u7a76\u767c\u73feST2\u578b<em>A. baumannii<\/em>\u682a\u5c55\u73fe\u66f4\u5f37\u7684\u81f4\u75c5\u6027\u8207\u6297\u85e5\u6027\uff08Int J Antimicrob Agents. 2024 Dec;64(6):107358\uff09\uff0c\u51f8\u986f\u5176\u70ba\u65b0\u8208\u9ad8\u98a8\u96aa\u75c5\u539f\u9ad4\u7684\u5a01\u8105\u3002\u6211\u5011\u6b63\u91dd\u5c0d\u591a\u7a2e\u5177\u985e\u4f3c\u9ad8\u98a8\u96aa\u7279\u6027\u7684\u83cc\u7a2e\u5c55\u958b\u76f8\u95dc\u7814\u7a76\u3002<\/p>\n<p>\u4e09\u3001\u61c9\u7528\u5fae\u751f\u7269\u5b78: \u6211\u7684\u61c9\u7528\u5fae\u751f\u7269\u5b78\u7814\u7a76\u81f4\u529b\u65bc\u5c07\u57fa\u790e\u7814\u7a76\u6210\u679c\u8f49\u8b6f\u70ba\u6cbb\u7642\u7b56\u7565\uff0c\u805a\u7126\u65bc\u76ca\u751f\u83cc\u3001\u5c0f\u5206\u5b50\u6297\u83cc\u7269\u8cea\u8207\u566c\u83cc\u9ad4\u7642\u6cd5\u3002\u6211\u5011\u9451\u5b9a\u51fa<em>Lactiplantibacillus pentosus<\/em> SLC13\u8207\u5176\u4ed6\u672c\u571f\u83cc\u682a\u5177\u5099\u6297\u75c5\u539f\u83cc\u8207\u514d\u75ab\u8abf\u7bc0\u6f5b\u529b\uff08BMC Microbiol. 2022 Nov 21;22(1):277\uff1bBMC Microbiol. 2024 Mar 11;24(1):85\uff09\uff0c\u76ee\u524d\u6b63\u63a2\u8a0e\u5176\u6291\u83cc\u7684\u5206\u5b50\u6a5f\u5236\u3002\u91dd\u5c0d\u9769\u862d\u6c0f\u967d\u6027\u75c5\u539f\u83cc\uff0c\u6211\u5011\u7814\u7a76\u4e86\u7522\u751flugdunin\u7684<em>S. lugdunensis<\/em>\uff0c\u767c\u73fe\u5176\u6297\u83cc\u6d3b\u6027\u53ef\u80fd\u53d7CRISPR-Cas\u7cfb\u7d71\u8abf\u63a7\uff0c\u5f8c\u7e8c\u7814\u7a76\u6b63\u9032\u4e00\u6b65\u63a2\u8a0e\u5176\u751f\u5408\u6210\u7684\u8abf\u7bc0\u6a5f\u5236\uff08Microbiol Spectr. 2023 Sep 21;11(5):e0129823\uff09\u3002\u8207\u99ac\u4f86\u4e9e\u5927\u5b78\u5408\u4f5c\uff0c\u6211\u5011\u8a55\u4f30\u4e86indolenine\u884d\u751f\u72694e\uff0c\u4e26\u8b49\u5be6\u5176\u5728\u7d30\u80de\u8207\u52d5\u7269\u6a21\u578b\u4e2d\u5177\u6297\u751f\u7269\u819c\u6d3b\u6027\uff08Antimicrob Agents Chemother. 2025 Jul 23:e0019925\uff09\uff0c\u5f8c\u7e8c\u4e5f\u6b63\u8a55\u4f30\u5176\u5176\u4ed6\u884d\u751f\u7269\u8207\u4f5c\u7528\u6a5f\u5236\u3002\u6b64\u5916\uff0c\u6211\u5011\u4ea6\u8b49\u5be6\u4f4e\u80fd\u91cf\u9707\u6ce2\u7642\u6cd5\u53ef\u6709\u6548\u6cbb\u7642UPEC\u5f15\u8d77\u7684\u5927\u9f20\u8180\u80f1\u708e\uff08Int Urol Nephrol. 2025 Jan;57(1):49-61\uff09\u3002\u5728\u566c\u83cc\u9ad4\u7642\u6cd5\u65b9\u9762\uff0c\u6211\u5011\u6210\u529f\u5206\u96e2\u51fa\u91dd\u5c0dcarbapenem-resistant <em>Enterobacter cloacae<\/em>\u7684\u88c2\u89e3\u578b\u566c\u83cc\u9ad4\uff0c\u65bc\u8815\u87f2\u8207\u5c0f\u9f20\u611f\u67d3\u6a21\u578b\u4e2d\u5747\u986f\u8457\u63d0\u5347\u5b58\u6d3b\u7387\uff08Microbiology Spectrum, In revision\uff09\u3002\u5728\u74b0\u5883\u5fae\u751f\u7269\u5b78\u9818\u57df\uff0c\u6211\u5011\u5831\u5c0e\u7d93\u5de5\u7a0b\u8a2d\u8a08\u7684Bi\u2082Te\u2083\u5948\u7c73\u7247\u65bc\u6d77\u6d0b\u9632\u6c59\u61c9\u7528\u4e2d\u5c55\u73fe\u512a\u7570\u7684haloperoxidase\u6d3b\u6027\uff08Small. 2024 Oct;20(43):e2401929\uff09\u3002\u8fd1\u671f\uff0c\u6211\u5011\u5df2\u555f\u52d5\u91dd\u5c0d<em>Akermansia muciniphila<\/em>\u8207<em>Bacteroides<\/em>\u7b49\u6b21\u4e16\u4ee3\u76ca\u751f\u83cc\u7684\u7814\u7a76\uff0c\u63a2\u8a0e\u5176\u65bc\u8178\u809d\u8ef8\u8abf\u63a7\u8207\u9152\u7cbe\u6027\u809d\u75c5\u7b49\u4ee3\u8b1d\u75be\u75c5\u6cbb\u7642\u4e0a\u7684\u6f5b\u529b\u3002\u9019\u4e9b\u7814\u7a76\u986f\u793a\u6211\u5011\u81ea\u83cc\u682a\u7be9\u9078\u81f3\u8f49\u8b6f\u61c9\u7528\u65bc\u5fae\u751f\u7269\u6cbb\u7642\u7522\u54c1\u958b\u767c\u7684\u5b8c\u6574\u7814\u7a76\u93c8\u3002<\/p>\n<h2><strong>Laboratory Members<\/strong><\/h2>\n<p>PhD students<\/p>\n<ul>\n<li>Jazon Harl Hidrosollo<\/li>\n<li>Yen-Zheng Zhang<\/li>\n<li>Pei-Yun Kuo<\/li>\n<li>Tran Thi Dieu Thuy<\/li>\n<li>Tran Thi Thuy Duong<\/li>\n<li>Carl\u00a0Jay Ballena Bregente<\/li>\n<li>Pek\u00a0Kee Chen<\/li>\n<li>Pei-Chun Tu<\/li>\n<li>Ya-Yu Zheng<\/li>\n<li>Nevia Longjam<\/li>\n<\/ul>\n<p>Master students<\/p>\n<ul>\n<li>Alonso Enrique Africa<\/li>\n<li>Tzu-Lin Chang<\/li>\n<li>Jia-Yu Xie<\/li>\n<li>Laishram Yashmine Devi<\/li>\n<li>Yi-Ru Boey<\/li>\n<li>Rong-Xuan Wu<\/li>\n<li>Nguyen Van Tat Thanh<\/li>\n<li>Yi-Chien\u00a0Kao<\/li>\n<li>Shen-Shawn Ruan<\/li>\n<li>Ramgie Micaller Bartolata<\/li>\n<li>\u5433\u4f73\u5029<\/li>\n<\/ul>\n<p>Undergraduate students<\/p>\n<ul>\n<li>\u674e\u4f73\u82ae<\/li>\n<li>\u5b6b\u4e8e\u7136<\/li>\n<li>\u856d\u4ef2\u752b<\/li>\n<li>\u6797\u8afa\u8c50<\/li>\n<li>\u912d\u5b87\u5747<\/li>\n<li>\u9ad8\u7487<\/li>\n<\/ul>\n<h2><strong>Laboratory Photos<\/strong><\/h2>\n<div style=\"display:flex; gap:20px; flex-wrap:wrap;\">\n<div style=\"flex:1; min-width:220px;\">\n    <img decoding=\"async\"\n    src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image004.jpg\"\n    alt=\"\u5be6\u9a57\u5ba4\u6210\u54e1\uff08\u4e00\uff09\"\n    style=\"width:100%; height:auto;\">\n  <\/div>\n<div style=\"flex:1; min-width:220px;\">\n    <img decoding=\"async\"\n    src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2025\/06\/image003.jpg\"\n    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