{"id":1903,"date":"2026-07-30T09:51:55","date_gmt":"2026-07-30T01:51:55","guid":{"rendered":"https:\/\/imi.nycu.edu.tw\/%e5%bc%b5%e9%81%93%e6%ac%a3%e5%8a%a9%e7%90%86%e6%95%99%e6%8e%88tao-hsin-chang\/"},"modified":"2026-07-30T10:36:08","modified_gmt":"2026-07-30T02:36:08","slug":"tao-hsin-chang","status":"publish","type":"post","link":"https:\/\/imi.nycu.edu.tw\/en\/tao-hsin-chang\/","title":{"rendered":"Tao-Hsin Chang"},"content":{"rendered":"<div class=\"row\"  id=\"row-2102851860\">\n\n\t<div id=\"col-1183471886\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<ul>\n<li>Assistant Professor<\/li>\n<li>Area of Expertise\uff1a Structural &amp; Synthetic Biology,\u00a0 Cell Signaling,\u00a0 Protein Design, Neurovascular Biology,\u00a0 Immunology &amp; Microbiology<\/li>\n<li>Office Location\uff1a Biomedical Building (R402)<\/li>\n<li>Office Phone\uff1a +886-2-28267114<\/li>\n<li>Lab Phone\uff1a +886-2-28267000 ext 65621<\/li>\n<li>Personal Website\uff1aUnder construction<\/li>\n<li>ORCID\uff1a https:\/\/orcid.org\/0000-0001-7242-2585&nbsp;<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-250786248\" class=\"col medium-6 small-12 large-6\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1895\" src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/\u5f35\u9053\u6b23\u8001\u5e2b_\u5c65\u6b77\u5f62\u8c61\u7167\u96fb\u5b50\u6a94.jpg\" alt=\"\u5f35\u9053\u6b23\u8001\u5e2b\" width=\"1000\" height=\"1287\" srcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/\u5f35\u9053\u6b23\u8001\u5e2b_\u5c65\u6b77\u5f62\u8c61\u7167\u96fb\u5b50\u6a94.jpg 1000w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/\u5f35\u9053\u6b23\u8001\u5e2b_\u5c65\u6b77\u5f62\u8c61\u7167\u96fb\u5b50\u6a94-233x300.jpg 233w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/\u5f35\u9053\u6b23\u8001\u5e2b_\u5c65\u6b77\u5f62\u8c61\u7167\u96fb\u5b50\u6a94-796x1024.jpg 796w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/\u5f35\u9053\u6b23\u8001\u5e2b_\u5c65\u6b77\u5f62\u8c61\u7167\u96fb\u5b50\u6a94-768x988.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/p>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n\n\t\t<div class=\"tabbed-content\">\n\t\t\t\n\t\t\t<ul class=\"nav nav-tabs nav-uppercase nav-size-normal nav-left\" role=\"tablist\"><li id=\"tab-professional-experience\" class=\"tab active has-icon\" role=\"presentation\"><a href=\"#tab_professional-experience\" role=\"tab\" aria-selected=\"true\" aria-controls=\"tab_professional-experience\"><span>Professional Experience<\/span><\/a><\/li>\n<li id=\"tab-selected-honors-and-awards\" class=\"tab has-icon\" role=\"presentation\"><a href=\"#tab_selected-honors-and-awards\" tabindex=\"-1\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab_selected-honors-and-awards\"><span>Selected Honors and Awards<\/span><\/a><\/li>\n<li id=\"tab-publications-and-research-projects\" class=\"tab has-icon\" role=\"presentation\"><a href=\"#tab_publications-and-research-projects\" tabindex=\"-1\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab_publications-and-research-projects\"><span>Publications and Research Projects<\/span><\/a><\/li>\n<li id=\"tab-laboratory-overview\" class=\"tab has-icon\" role=\"presentation\"><a href=\"#tab_laboratory-overview\" tabindex=\"-1\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab_laboratory-overview\"><span>Laboratory Overview<\/span><\/a><\/li><\/ul><div class=\"tab-panels\"><div id=\"tab_professional-experience\" class=\"panel active entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-professional-experience\">\n<div class=\"av-special-heading av-1wyde5j-178bec8df35a0d430fe73e96c64f78ce av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<div class=\"av-special-heading av-1wyde5j-178bec8df35a0d430fe73e96c64f78ce av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<div class=\"av-special-heading av-1xclv8f-a3f0d2cecbec6a4fcaa467b70d690622 av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<div class=\"av-special-heading av-1xfg3sb-bf432a71e6108c7bfdf2b1ea53665e9b av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<h2><strong>Education<\/strong><\/h2>\n<\/div>\n<section class=\"av_textblock_section av-1urtw17-810d4a153e2fb55d9a5ae5516be971df\">\n<div class=\"avia_textblock av_inherit_color\">\n<ul>\n<li>Ph.D. in Clinical Medicine, University of Oxford, UK (2015)<\/li>\n<li>M.Sc. in Biochemical Sciences, National Taiwan University, TW (2006)<\/li>\n<li>B.Sc. in Plant Pathology &amp; Chemistry (sub-major), National Chung Hsing University, TW (2004)<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<div class=\"av-special-heading av-1r4fy97-beb19cb75e91f48b46d5670683469203 av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-12 el_after_av_hr el_before_av_textblock \">\n<h2><strong>Professional Experience<\/strong><\/h2>\n<\/div>\n<section class=\"av_textblock_section av-1q69vuj-9b0a32805d5ae45a5a628ac1d7300142\">\n<div class=\"avia_textblock av_inherit_color\">\n<ul>\n<li>Assistant Professor, Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, TW (2026 \u2013 Present)<\/li>\n<li>Mentor, the Mentoring Program, Taiwanese American Association of Biotechnology (TAAB), US (2024 \u2013 Present)<\/li>\n<li>Principal Scientist, GlaxoSmithKline (GSK), US (2025 \u2013 2026)<\/li>\n<li>Senior Scientist, Integer Bio, US (2024 \u2013 2025)<\/li>\n<li>Research Specialist, Howard Hughes Medical Institute (HHMI), US (2020 \u2013 2023)<\/li>\n<li>Human Frontier Science Program (HFSP) Long-Term Fellow, Johns Hopkins University School of Medicine, US (2017 \u2013 2020)<\/li>\n<li>Postdoctoral Research Scientist, University of Oxford, UK (2015 \u2013 2017)<\/li>\n<li>Research Assistant, Academia Sinica, TW (2007 \u2013 2010)<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<div class=\"hr av-1opjb2z-1df0a1f1558cbccfb94bd8939af790e2 hr-short avia-builder-el-14 el_after_av_textblock el_before_av_heading hr-left\"><\/div>\n<div class=\"hr av-1ei2s8b-1570bb28c39f36e084a341106c7c4d20 hr-short avia-builder-el-18 el_after_av_textblock el_before_av_textblock hr-left\"><\/div>\n<\/div>\n<\/div>\n<section class=\"av_textblock_section av-1682wiv-8006e72fe9d03e2941376d8c27411fd8\"><\/section>\n<\/div>\n<section class=\"av_textblock_section av-1682wiv-8006e72fe9d03e2941376d8c27411fd8\"><\/section>\n<\/div>\n<div id=\"tab_selected-honors-and-awards\" class=\"panel entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-selected-honors-and-awards\">\n<div class=\"av-special-heading av-1wyde5j-178bec8df35a0d430fe73e96c64f78ce av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<div class=\"av-special-heading av-1wyde5j-178bec8df35a0d430fe73e96c64f78ce av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<div class=\"av-special-heading av-1xclv8f-a3f0d2cecbec6a4fcaa467b70d690622 av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \">\n<div class=\"av-special-heading av-1xfg3sb-bf432a71e6108c7bfdf2b1ea53665e9b av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-9 el_before_av_textblock avia-builder-el-first \"><\/div>\n<div class=\"av-special-heading av-1mcllx7-51bb03e00041bcf93e2dae84332b5d92 av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-15 el_after_av_hr el_before_av_textblock \">\n<h2><strong>Awards<\/strong><\/h2>\n<\/div>\n<section class=\"av_textblock_section av-1kvidwr-5f8d60fee2c741812641702f938f3d70\">\n<div class=\"avia_textblock av_inherit_color\">\n<p>&#8211; Yushan Young Fellow, Ministry of Education, TW (2026 \u2013 2030)<\/p>\n<p>&#8211; Human Frontier Science Program (HFSP) Long-Term Fellowship (2017 \u2013 2020)<\/p>\n<p>&#8211; Travel Grant Award, Annual Meeting of Biophysical Society, US (2016)<\/p>\n<p>&#8211; Nuffield Department of Clinical Medicine (NDM) Graduate Research Prize, University of Oxford, UK (2015)<\/p>\n<p>&#8211; Best Student Presentation Award, EMBO workshop on Wnt Signaling: Stem Cells, Development, and Disease, AU (2014)<\/p>\n<p>&#8211; Clarendon Scholarship, Somerville College Scholarship, NDM Prize Studentship, University of Oxford, UK (2010-2014)<\/p>\n<p>&#8211; Dean Award, National Taiwan University, TW (2006)<\/p>\n<p>&#8211; Best Presentation Award, Annual Meeting of the Taiwan Society of Biochemistry and Molecular Biology, TW (2005)<\/p>\n<p>&#8211; Ching O Medal Award, National Chung Hsing University, TW (2000)<\/p>\n<h2><strong>Conference Chair \/ Organizer<\/strong><\/h2>\n<p>&#8211; Co-organizer and committee, Taiwanese Life Science Association in the UK (2012)<\/p>\n<h2><strong>Invited International Talks<\/strong><\/h2>\n<p>&#8211; Director Special Seminar, National Eye Institute, NIH, US (2023)<\/p>\n<p>&#8211; Human Frontier Science Program Awardees Meeting, FR (2021)<\/p>\n<p>&#8211; American Crystallographic Association Annual Meeting, US (2020)<\/p>\n<p>&#8211; British Biophysical Society Biennial Meeting, UK (2016)<\/p>\n<\/div>\n<\/section>\n<div class=\"hr av-1ei2s8b-1570bb28c39f36e084a341106c7c4d20 hr-short avia-builder-el-18 el_after_av_textblock el_before_av_textblock hr-left\"><\/div>\n<\/div>\n<\/div>\n<section class=\"av_textblock_section av-1682wiv-8006e72fe9d03e2941376d8c27411fd8\"><\/section>\n<\/div>\n<section class=\"av_textblock_section av-1682wiv-8006e72fe9d03e2941376d8c27411fd8\"><\/section>\n<\/div>\n<div id=\"tab_publications-and-research-projects\" class=\"panel entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-publications-and-research-projects\">\n<div class=\"av-special-heading av-10md8rr-c752fab7bc091682958c7effdda61054 av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-25 el_after_av_hr el_before_av_textblock \">\n<div class=\"av-special-heading av-119zicf-fe0cbcb596da82d940a795e95a0e6b9a av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-26 el_after_av_hr el_before_av_textblock \">\n<div class=\"av-special-heading av-119txq3-a91c0104c08c0ee8e169fb4e5def782c av-special-heading-h2 custom-color-heading blockquote modern-quote avia-builder-el-23 el_after_av_hr el_before_av_textblock \">\n<h2 class=\"av-special-heading-tag\"><strong>Publications<\/strong><\/h2>\n<\/div>\n<section class=\"av_textblock_section av-ywj5vv-e4ac3bc87620735f910c2caf5acbc32a\">\n<div class=\"avia_textblock\">\n<ul>\n<li>&#8211; Hillier, J., Zhao, Y., Carrique, L., Malinauskas, T., Ruza, R.R., Chang, T.H., Yi, G., Duyvesteyn. H., Yu, J., Lu, W., Pardon, E., Steyaert, J., Zhu, Y., Ni, T., and Jones, E.Y. (2024). Structural Insights into Frizzled3 through Nanobody Modulators. Nature Communications 15, 7228 DOI: 10.1038\/s41467-024-51451-1<\/li>\n<li>&#8211; Zhu, N., Smallwood, P.M., Rattner, A., Chang, T.H., Williams, J., Wang, Y., and Nathans, J. (2024). Utility of protein-protein binding surfaces composed of anti-parallel alpha-helices and beta-sheets selected by phage display. Journal of Biological Chemistry 300, 107283. DOI: 10.1016\/j.jbc.2024.107283<\/li>\n<li>&#8211; Chang, T.H.#, Hsieh, F.L., Gu, X., Smallwood, P.M., Kavran, M.J., Gabelli, S.B., and Nathans, J.# (2023). Structural insights into Plasmalemma Vesicle-Associated Protein (PLVAP): implications for vascular endothelial diaphragms and fenestrae. Proc Natl Acad Sci U S A 120, e2221103120 DOI: 10.1073\/pnas.2221103120 #Co-corresponding author<\/li>\n<li>&#8211; Hsieh, F.L.*, Chang, T.H.*#, Gabelli, S.B., and Nathans, J.# (2023). Structure of Wnt inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a Cell-Surface Lipid-Binding Protein. Proc Natl Acad Sci U S A 120, e2217096120 DOI: 10.1073\/pnas.2217096120 *Equal Contribution, #Co-corresponding author<\/li>\n<li>&#8211; Chang, T.H., Hsieh, F.L., Smallwood, P.M., Gabelli, S.B., and Nathans, J. (2020). Structure of the RECK CC domain, an evolutionary anomaly. Proc Natl Acad Sci USA 117, 15104-15111 DOI: 10.1073\/pnas.2006332117<\/li>\n<li>&#8211; Chang, T.H., Hsieh, F.L., Zebisch, M., Harlos, K., Elegheert, J., and Jones, E.Y. (2015). Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5\/6, and proteoglycan. eLife 4, e06554 DOI: 10.7554\/elife.06554<\/li>\n<li>&#8211; Kakugawa, S.*, Langton, P.F.*, Zebisch, M.*, Howell, S.A., Chang, T.H., Liu, Y., Feizi, T., Bineva, G., O&#8217;Reilly, N., Snijders, A.P., Jones, E.Y., and Vincent, J.P. (2015). Notum deacylates Wnt proteins to suppress signalling activity. Nature 519, 187-192. *Equal Contribution DOI: 10.1038\/nature14259<\/li>\n<li>&#8211; Chang, C.K., Teng, K.H., Lin, S.W., Chang, T.H., and Liang, P.H. (2013). Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction. Biochemistry 52, 2783-2792. DOI: 10.1021\/bi4001276<\/li>\n<li>&#8211; Chang, T.H.*, Chang, S.J.*, Hsieh, F.L., Ko, T.P., Lin, C.T., Ho, M.R., Wang, I., Hsu, S.T., Guo, R.T., Chang, W., and Wang, A.H. (2013). Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein. PLoS pathogens 9, e1003563. *Equal Contribution DOI: 10.1371\/journal.ppat.1003563<\/li>\n<li>&#8211; Hsieh, F.L.*, Chang, T.H.*, Ko, T.P., and Wang, A.H. (2011). Structure and mechanism of an Arabidopsis medium\/long-chain-length prenyl pyrophosphate synthase. Plant Physiology 155, 1079-1090. *Equal Contribution (Featured on Cover) DOI: 10.1104\/pp.110.168799<\/li>\n<li>&#8211; Hsieh, F.L., Chang, T.H., Ko, T.P., and Wang, A.H. (2010). Enhanced specificity of mint geranyl pyrophosphate synthase by modifying the R-loop interactions. Journal of Molecular Biology 404, 859-873. DOI: 10.1016\/j.jmb.2010.10.011<\/li>\n<li>&#8211; Chang, T.H.#, Hsieh, F.L., Ko, T.P., Teng, K.H., Liang, P.H., and Wang, A.H.# (2010). Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. The Plant Cell 22, 454-467. #Co-corresponding author (Highlighted in A-IMBN research and Photon Factory science) DOI: 10.1105\/tpc.109.071738<\/li>\n<li>&#8211; C, K.M.C.*, Hudock, M.P.*, Zhang, Y.*, Guo, R.T., Cao, R., No, J.H., Liang, P.H., Ko, T.P., Chang, T.H., Chang, S.C., Chang, Y., Axelson, J., Kumar, A., Wang, A.H. and Oldfield, E. (2008). Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. Journal of Medicinal Chemistry 51, 5594-5607. *Equal Contribution DOI: 10.1021\/jm800325y<\/li>\n<li>&#8211; Guo, R.T.*, Cao, R.*, Liang, P.H., Ko, T.P., Chang, T.H., Hudock, M.P., Jeng, W.Y., Chen, C.K., Zhang, Y., Song, Y., Kuo, C.J., Yin, F., Oldfield, E., and Wang, A.H. (2007). Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci USA 104, 10022-10027. *Equal Contribution DOI: 10.1073\/pnas.0702254104<\/li>\n<li>&#8211; Chang, T.H., Guo, R.T., Ko, T.P., Wang, A.H., and Liang, P.H. (2006). Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination. Journal of Biological Chemistry 281, 14991-15000. (Highlighted in SPring-8 Research Frontiers) DOI: 10.1074\/jbc.M512886200<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<h2><strong>Books:<\/strong><\/h2>\n<p>&#8211; Hsieh, F.L.#, and Chang, T.H.# (2023). Antibody Display technology (ADbody) to present challenging and unstable target proteins on the antibodies. Methods in Molecular Biology (Genotype Phenotype Coupling 373-382) DOI: 10.1007\/978-1-0716-3279-6_21 #Co-corresponding authors<\/p>\n<\/div>\n<div id=\"tab_laboratory-overview\" class=\"panel entry-content\" role=\"tabpanel\" aria-labelledby=\"tab-laboratory-overview\">\n<h2><strong>Research Focus:<\/strong><\/h2>\n<p><strong>Structural &amp; Synthetic Cell Signaling Laboratory<\/strong><\/p>\n<p>We bridge fundamental science and translational medicine to tackle major biomedical challenges. Our core mission is to decode, manipulate, and reprogram the cellular signaling networks that regulate human health and drive disease. Integrating structural biology (X-ray crystallography &amp; Cryo-EM), cell biology, and AI-guided protein design, our multidisciplinary approach seeks to discover novel therapeutic avenues for cancer, vascular disorders, neurodegenerative conditions, and infectious diseases.<\/p>\n<p><strong>Our Key Research Directions<\/strong><\/p>\n<p>\u2022 Decoding Cellular Signaling: Uncovering how key signaling pathways control neurovascular development, immune defense, and tumorigenesis.<\/p>\n<p>\u2022 Understanding Disease Mechanisms: Mapping out how faulty or dysregulated pathway signaling shifts cellular behavior from healthy to: pathological states.<\/p>\n<p>\u2022 Engineering New Therapeutics: Harnessing AI and synthetic biology to design custom proteins capable of reprogramming cellular signals for clinical and scientific applications.<\/p>\n<h2><strong>Lab Members:<\/strong><\/h2>\n<p><strong>Join Our Team<\/strong><\/p>\n<p>Are you interested in working with us? Applications are open to both domestic and international students. We welcome applicants from diverse backgrounds (both scientific and non-traditional).<\/p>\n<p>Potential candidates are encouraged to reach out via email. Please include your CV and a short statement outlining your interest in our lab. Additional supporting documents (such as transcripts or a thesis) are welcome but not required.<\/p>\n<p>We also encourage applications for other positions, including postdoctoral fellows and visiting scientists, particularly those who have or can secure external funding.<\/p>\n<p><strong>Current Lab Status<\/strong><\/p>\n<p>Our team is growing! An experienced Research Assistant and an established Postdoctoral Fellow will be joining the lab in early 2027.<\/p>\n<h2><strong>Lab Photos:<\/strong><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1901\" src=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/image001.png\" alt=\"\u5be6\u9a57\u5ba4\u7167\u7247\" width=\"1474\" height=\"541\" srcset=\"https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/image001.png 1474w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/image001-300x110.png 300w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/image001-1024x376.png 1024w, https:\/\/imi.nycu.edu.tw\/wp-content\/uploads\/2026\/07\/image001-768x282.png 768w\" sizes=\"auto, (max-width: 1474px) 100vw, 1474px\" \/><\/p>\n<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":1904,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[],"class_list":["post-1903","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-30"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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