Ivan Dzhagalov 葛一樊副教授 - 國立陽明交通大學微生物及免疫學研究所

葛一樊副教授

微生物及免疫學研究所副教授
專長領域:thymus. T cell development, macrophages, phagocytosis, efferocytosis, fibroblasts, Heparan sulfate, heparin, mast cells
辦公室位置: 生物醫學大樓(R406)
TEL (辦公室): +886-2-28267231
TEL (實驗室): +886-2-28267000 ext 65623
E-mail: ivan.dzhagalov@nycu.edu.tw
Web site: http://www.ym.edu.tw/~ivan/index_e.html
ORCID: 0000-0001-9209-4582

主要經歷論文著作計畫實驗室

學歷

Trakia University Medical School, Stara Zagora, Bulgaria – M.D. (1994 – 2000)

Duke University, Durham, NC, U.S.A – Ph.D. (2001 – 2007)

經歷

University of California, Berkeley, USA – postdoctroral fellow (2007 – 2012)

Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan – Assistant Professor (2013 – 2021)

Institute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei, Taiwan – Associate Professor (2021 – present)

論文

1. Fan HH, Tsai TL, Dzhagalov IL, Hsu CL. Evaluation of Mitochondria Content and Function in Live Cells by Multicolor Flow Cytometric Analysis. Methods Mol Biol. 2021; 2276:203-213.
2. Hsu HP, Chen YT, Chen YY, Lin CY, Chen PY, Liao SY, Lim CCY, Yamaguchi Y, Hsu CL, Dzhagalov IL. Heparan sulfate is essential for thymus growth. J Biol Chem. 2021; 296:100419.
3. Chu CF, Feng HK, Sun KH, Hsu CL, Dzhagalov IL. Examination of Fas-Induced Apoptosis of Murine Thymocytes in Thymic Tissue Slices Reveals That Fas Is Dispensable for Negative Selection. Front Cell Dev Biol. 2020; 8:586807.
4. Maslova A, Ramirez RN, Ma K, Schmutz H, Wang C, Fox C, Ng B, Benoist C, Mostafavi S et al. Immunological Genome Project. Deep learning of immune cell differentiation. Proc Natl Acad Sci U S A. 2020 Sep 25:202011795.
5. Immunological Genome Project. ImmGen at 15. Nat Immunol. 2020 Jul; 21(7):700-703.
6. Chou YJ, Lin CC, Dzhagalov IL, Chen NC, Lin CH, Lin CC, Chen ST, Chen KH, Fu SL. Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy. Sci Rep. 2020 May 21; 10(1):8422.
7. Zhou TA, Hsu CL, Dzhagalov IL. Testing the efficiency and kinetics of negative selection using thymic slices. Methods Mol Biol. 2020; 2111:205-219
8. Kurd NS, Lutes LK, Yoon J, Chan SW, Dzhagalov IL, Hoover AR, Robey EA. A role for phagocytosis in inducing cell death during thymocyte negative selection. Elife. 2019; 8:e48097
9. Fontaine MAC, Westra MM, Bot I, Jin H, Franssen AJPM, Bot M, de Jager SCA, Dzhagalov I, He YW, van Vlijmen BJM, Gijbels MJJ, Reutelingsperger CP, van Berkel TJC, Sluimer JC, Temmerman L, Biessen EAL. Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells. Sci Rep. 2019; 9(1):14547.
10. Hsu C-L, Dzhagalov IL. Metabolite Transporters—The Gatekeepers for T Cell Metabolism. Immunometabolism. 2019;1:e190012.
11. Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang HR, Jung JU, Ting JP. NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. Cell Host Microbe. 2019; 25(4):602-616.
12. Wei CW, Zhou TA, Dzhagalov IL, Hsu CL. Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T J. Vis. Exp. 2019; 143:e58844.
13. Hsu MJ, Chang FP, Lu YH, Hung SC, Wang YC, Yang AH, Lee HJ, Sung SH, Wang YF, Yu WC, Hsu TR, Huang PH, Chang SK, Dzhagalov I, Hsu CL, Niu DM. Identification of lysosomal and extralysosomal globotriaosylceramide (Gb3) accumulation before the occurrence of typical pathological changes in the endomyocardial biopsies of Fabry disease patients. Genet Med. 2019; 21(1):224-232
14. Wei CW, Lee CY, Lee DJ, Chu CF, Wang JC, Wang TC, Jane WN, Chang ZF, Leu CM, Dzhagalov IL, Hsu CL. Equilibrative Nucleoside Transporter 3 Regulates T Cell Homeostasis by Coordinating Lysosomal Function with Nucleoside Availability. Cell Rep. 2018; 23(8):2330-2341.

實驗室介紹

Research focus: Our research focuses on the development and functional specialization of the macrophages in the thymus. While the ability of these cells to engulf dying thymocytes is well known, much of the b. We are particularly interested in: 1) the mutually beneficial interactions between thymic macrophages and other stromal cells in the thymus; 2) key metabolic adaptation of thymic macrophages; 3) functions other than phagocytosis performed by thymic macrophages to support T cell development in the thymus.

Interactions between thymic macrophages (green), fibroblasts (red), and CD301⁺ dendritic cells (cyan) in the cortex of the thymus. Image by Hui-Kui Cheng.

葛一樊副教授

學歷

Trakia University Medical School, Stara Zagora, Bulgaria – M.D. (1994 – 2000)

Duke University, Durham, NC, U.S.A – Ph.D. (2001 – 2007)

經歷

University of California, Berkeley, USA – postdoctroral fellow (2007 – 2012)

Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan – Assistant Professor (2013 – 2021)

Institute of Microbiology and Immunology, National Yang-Ming Chiao-Tung University, Taipei, Taiwan – Associate Professor (2021 – present)

論文

Fan HH, Tsai TL, Dzhagalov IL, Hsu CL. Evaluation of Mitochondria Content and Function in Live Cells by Multicolor Flow Cytometric Analysis. Methods Mol Biol. 2021; 2276:203-213.

Hsu HP, Chen YT, Chen YY, Lin CY, Chen PY, Liao SY, Lim CCY, Yamaguchi Y, Hsu CL, Dzhagalov IL. Heparan sulfate is essential for thymus growth. J Biol Chem. 2021; 296:100419.

Chu CF, Feng HK, Sun KH, Hsu CL, Dzhagalov IL. Examination of Fas-Induced Apoptosis of Murine Thymocytes in Thymic Tissue Slices Reveals That Fas Is Dispensable for Negative Selection. Front Cell Dev Biol. 2020; 8:586807.

Maslova A, Ramirez RN, Ma K, Schmutz H, Wang C, Fox C, Ng B, Benoist C, Mostafavi S et al. Immunological Genome Project. Deep learning of immune cell differentiation. Proc Natl Acad Sci U S A. 2020 Sep 25:202011795.

Immunological Genome Project. ImmGen at 15. Nat Immunol. 2020 Jul; 21(7):700-703.

Chou YJ, Lin CC, Dzhagalov IL, Chen NC, Lin CH, Lin CC, Chen ST, Chen KH, Fu SL. Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy. Sci Rep. 2020 May 21; 10(1):8422.

Zhou TA, Hsu CL, Dzhagalov IL. Testing the efficiency and kinetics of negative selection using thymic slices. Methods Mol Biol. 2020; 2111:205-219

Kurd NS, Lutes LK, Yoon J, Chan SW, Dzhagalov IL, Hoover AR, Robey EA. A role for phagocytosis in inducing cell death during thymocyte negative selection. Elife. 2019; 8:e48097

Hsu C-L, Dzhagalov IL. Metabolite Transporters—The Gatekeepers for T Cell Metabolism. Immunometabolism. 2019;1:e190012.

Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang HR, Jung JU, Ting JP. NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. Cell Host Microbe. 2019; 25(4):602-616.

Wei CW, Zhou TA, Dzhagalov IL, Hsu CL. Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T J. Vis. Exp. 2019; 143:e58844.

Wei CW, Lee CY, Lee DJ, Chu CF, Wang JC, Wang TC, Jane WN, Chang ZF, Leu CM, Dzhagalov IL, Hsu CL. Equilibrative Nucleoside Transporter 3 Regulates T Cell Homeostasis by Coordinating Lysosomal Function with Nucleoside Availability. Cell Rep. 2018; 23(8):2330-2341.

實驗室介紹

實驗室成員

Current lab members:

PhD students:

Tyng-An Zhou/周庭安

Sandra Abril Herrera-Heredia/金珏儒

Hsuan-Po Hsu/徐璿博

Hsing-Kai Feng/馮興凱

MS students

Hui-Kui Cheng/鄭惠瑰

Nan-Kai Wang/王南開

Ching-Hsiang Chiu/邱敬翔

Yu-Chien Ma/馬語謙

Li-Wen Yu/余麗雯

實驗室照片