Shir-Ly Huang黃雪莉教授 - 國立陽明交通大學微生物及免疫學研究所

黃雪莉教授

微生物及免疫學研究所教授
專長領域: 細菌生化、細菌生理、蛋白質體學、藥物研發
辦公室位置: 生物醫學大樓(R312)
TEL (辦公室): +886-2-28267108
TEL (實驗室): +886-2-28267000 ext 65620
E-mail: sl.huang@nycu.edu.tw

主要經歷論文著作計畫實驗室

學歷

1990 美國愛荷華大學 (The University of Iowa) 微生物學系博士

1985 陽明醫學院微生物及免疫學研究所碩士

1983 台灣大學農業化學系學士

經歷

台灣微生物生態學學會理事長 (2014-2018)

美國微生物學會 Country Ambassador to Taiwan (2012-2015)

國立陽明交通大學國際事務處國際長 (2/2021~11/2021)

國立陽明大學國際事務處國際長 (8/2019~1/2021)

國立陽明大學微生物及免疫學研究所所長 (2/2017~2/2021)

國立陽明大學醫學院微生物學科科主任 (2/2017~2/2021)

國立中央大學生命科學系教授兼系主任 (8/2010~7/2013)

國立中央大學生物科技與生醫工程中心教授兼中心主任 (8/2007~7/2013)

生物技術開發中心製藥計畫藥物發展組研究員 (1992~1995)

美國禮萊藥廠 (Eli Lilly & Co.) 博士後研究員 (1991~1992)

獲獎榮譽

指導學生於國內外獲獎超過50人次

(校外獎項)

第十七屆國家新創獎新創精進獎 (2020)

台灣創新技術博覽會銀牌獎 (2018)

台北國際發明暨交易展銅牌獎 (2013)

千里馬盃全國創業競賽金牌 (2012)

日本舉辦第一屆台灣產學智慧財產展金賞 (2012)

台北國際發明暨交易展金牌獎(2011)

第八屆國家新創獎 (2011)

第七屆國家新創獎 (2010)

台灣農業化學會學術榮譽獎 (2008)

(校內獎項)

國立陽明交通大學生命科學院第三季重要期刊論文 (109年度)

醫學學系網路教學評量優良教師獎狀 (105-109學年度)

醫學系網路教學評量優良教師琉璃獎座 (107學年度)

研討會主持人/主辦人

2022	The 5th Annual Conference of Taiwan Microbiota Consortium, 2022 ACTMC (Session chair)
2021	The 4th Annual Conference of Taiwan Microbiota Consortium, 2021 ACTMC (Session chair)
2020, 2021	Pe-internship “Microbial biotechnology and drug discovery”, NYCU, Taiwan (Organizer)
2020	Taiwan-Australia Symposium on Microbiota Biomedical Exchange- Advances and Applications in Microbial Precision Medicine Technologies, Taiwan (Session chair)
2018, 2019	Summer school and internship “Microbial biotechnology and drug discovery”, NYMU, Taiwan (Organizer)
2018	2018 Annual Meeting of Taiwan Society of Microbial Ecology, Taiwan. (Symposium chair)
2017	2017 Annual Meeting of Taiwan Society of Microbial Ecology, Taiwan. (Symposium chair)
2017	Summer school and internship “Frontiers in Microbiome and Cancer Immunology”, NYMU, Taiwan (Organizer)
2017	The 9th Asian Symposium on Microbial Ecology, Korea (Symposium organizing committee, Session chair)
2016	The 8thAsian Symposium on Microbial Ecology, Taiwan (Symposium chair, Opening remarks, Keynote session chair)
2015	Cross-Straits Symposium on Environmental Microbiology, Taiwan (Symposium chair, Opening remarks, Keynote session chair)
2013	The 5th Taiwan-Korea-Japan International Symposium on Microbial Ecology (Symposium chair, Opening remarks, Keynote session chair)
2010	International Biogas and Biofuel Workshop (Workshop chair, Opening remarks, Keynote session chair)
2010	International Symposium on Microbial Ecology (Organizer, Keynote session chair)

國際合作學者

Dr. Kyoung Lee

Professor/Director, Department of Bio Health Science, Changwon National University, South Korea

Dr. Nguyen Ngoc Tuan

Lecturer/Assistant Dean, Faculty of Applied Sciences, Ton Duc Thang University, Vietnam

Dr. Marina L. Sidorenko,

Leading Researcher, Soil ecology sector, Federal Scientific Center of the East Asia Terrestrial Biodiversity, FEB RAS, Russia

國際邀請演講

Vietnam	2nd International Conference of Applied Science, Ton Duc Thang University, Ho Chi Minh City (2018) Thai Nguyen University of Agriculture and Forestry, Hanoi (2017) University of Science & Technology of, Hanoi (2017)
Japan	The 15th International Symposium on Biocatalysis and Agricultural Biotechnology, Hiroshima (2019) University of Tokyo Tokyo Institute of Technology
Korea	Pusan National University, Busan (2014, 2015) Changwon National University, Changwon (2014, 2015)
Australia	Australian Nuclear Science and Technology Organization
Russia	The 1st International Conference on North East Asia Biodiversity, Vladivostok (2018)
Taiwan	2019 MOST North America-Asia Pacific Science & Technology International Cooperation Research Symposium, Taipei The 11th Asian Symposium on Microbial Ecology, Taichung (2019) 2019 International Symposium of Microbiota Technology, Research, and Development, Taipei 5th Microbiome R&D and Business Collaboration Congress Asia (2019)

論文

Weng, Chen-Tsung, Shir-Ly Huang*, Hui-Wen Yang, Chih-Chin Kao, Cheng-Chung Wei, Yu-Feng Huang. 2021. Oral microbiota in xerostomia patients – a preliminary study. Journal of Dental Sciences. https://doi.org/10.1016/j.jds.2021.08.007 (Available online 28 August 2021)
Phan, Ha My Ti, Marina L. Sidorenko, Po-Chun Tsai, Shir-Ly Huang*. 2021. Whole-genome shotgun sequence of Bacillus mycoides strain U53, a psychrotolerant bacterium Isolated from Sakhalin Region, Russia. Microbiology Resource Announcements 10(1): e01257-20.
Dai, Shih-Ping, Wei-Shan Hsieh, Chien-Hua Chen, Yueh-Hao Lu, Hsu-Shan Huang, Der-Ming Chang, Shir-Ly Huang, Wei-Hsin Sun. 2020. TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain. Journal of Neuroinflammation 17(1): 170.
Rajendran, Ranjith Kumar, Yi-Wen Lee, Pei-Hsin Chou, Shir-Ly Huang, Roland Kirschner*, Chu-Ching Lin*. 2020. Biodegradation of the endocrine disrupter 4-t-octylphenol by the non-ligninolytic fungus Fusarium falciforme RRK20: Process optimization, estrogenicity assessment, metabolite identification and proposed pathways. Chemosphere 240, 124876.
Madda, Rashmi, Shih-Chang Lin, Wei- Hsin Sun*, Shir-Ly Huang*. Differential expressions of plasma proteins in systemic lupus erythematosus patients identified by proteomic analysis. Journal of Microbiology, Immunology and Infection 52(5), 816-826.
Hung, Kuo-Chan, Ngoc Tuan Nguyen, Yu-Ling Sun and Shir-Ly Huang*. 2019. Bio-Fenton reaction involved in the cleavage of the ethoxylate chain of nonionic surfactants by dihydrolipoamide dehydrogenase from Pseudomonas nitroreducens Scientific Reports 9(1), 6827.
Lim, Jae Yun, Munkhtsatsral Ganzorig, Shir-Ly Huang and Kyoung Lee. 2019. First Complete Genome Sequence of Haematobacter massiliensis OT1 (Chromosome and Multiple Plasmids), Isolated from Human Skin. Microbiology Resource Announcements 8(18), e00292-19.
Madda, Rashmi, Shih-Chang Lin, Wei-Hsin Sun* and Shir-Ly Huang*. 2018. Plasma proteomic analysis of systemic lupus erythematosus patients using liquid chromatography/tandem mass spectrometry with label-free quantification. PeerJ (6), e4730.
Lim, Jae Yun, Ingyu Hwang, Munkhtsatsral Ganzorig, Shir-Ly Huang, Gyu-Sung Cho, Charles M. A. P. Franz, Kyoung Lee. 2018. Complete genome sequences of three Moraxella osloensis strains isolated from human skin. Genome Announc 6(3), e01509-17.
Rajendran, Ranjith Kumar, Chu-Ching Lin, Shir-Ly Huang, Roland Kirschner. 2017. Enrichment, isolation, and biodegradation potential of long-branched chain alkylphenol degrading non-ligninolytic fungi from wastewater. Marine Pollution Bulletin 125(1-2), 416-425.
Hsieh, Wei-Shan, Chia-Chi Kung, Shir-Ly Huang, Shih-Chang Lin and Wei-Hsin Sun. 2017. TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis. Scientific Reports 7, 8870.
Kirschner, Roland, Pei-Lun Sun, Shir-Ly Huang, Chien-Lung Chen, Chih-Ping Yang. 2017. A case of bilateral otomycosis associated with Aspergillus flavus and terreus in Taiwan. Journal de Mycologie Médicale 27(3), 412-416.
Rajendran, Ranjith Kumar, Shir-Ly Huang, Chu-Ching Lin, Roland Kirschner. 2017. Biodegradation of the endocrine disrupter 4-tert-octylphenol by the yeast strain Candida rugopelliculosa RRKY5 via phenolic ring hydroxylation and alkyl chain oxidation pathways. Bioresource Technology 226, 55-64.
Tuan, Ngoc Nguyen, Chen-Wei Yeh, Po-Chun Tsai, Kyoung Lee*, Shir-Ly Huang*. 2016. Transposon mutagenesis identifies genes critical for growth of Pseudomonas nitroreducens TX1 on octylphenol polyethoxylates. Applied and Environmental Microbiology 82(22), 6584-6592.
Rajendran, Ranjith Kumar, Shir-Ly Huang, Chu-Ching Lin, Roland Kirschner. 2016. Aerobic degradation of estrogenic alkylphenols by yeasts isolated from a sewage treatment plant. RCS Advances 6(86), 82862-82871.
Lin, Yi-Wen, Chia-Chin Yang, Nguyen Ngoc Tuan, Shir-Ly Huang*. 2016. Diversity of octylphenol polyethoxylate-degrading bacteria: with a special reference to Brevibacterium TX4. International Biodeterioration & Biodegradation 115, 55-63.
Lin, Yi-Wen, Nguyen Ngoc Tuan, Shir-Ly Huang*. 2016. Metaproteomic analysis of the microbial community present in a thermophilic swine manure digester to allow functional characterization: A case study. International Biodeterioration & Biodegradation 115, 64-73.
Lin, Ting-Hsiang, Gia-Luen Guo, Wen-Song Hwang, Shir-Ly Huang*. 2016. The addition of hydrolyzed rice straw in xylose fermentation by Pichia stipitis to increase bioethanol production at the pilot-scale. Biomass and Bioenergy 91, 204-209.
Huang, Shir-Ly*, Nguyen Ngoc Tuan, and Kyoung Lee. 2016. Occurrence, human intake and biodegradation of estrogen-like nonylphenols and octylphenols. Current Drug Metabolism 17(3), 293-302.
Mulla, Sikandar I., Anyi Hu, Yuwen Wang, Qian Sun, Shir-Ly Huang*, Han Wang and Chang-Ping Yu*. 2016. Degradation of triclocarban by a triclosan-degrading Sphingomonas strain YL-JM2C. Chemosphere 144, 292-296.
Kirschner, Roland, Tien Hsu, Nguyen Ngoc Tuan, Chien-Lung Chen and Shir-Ly Huang*. 2015. Characterization of fungal and bacterial components in gut/fecal microbiome. Current Drug Metabolism 16(4), 272–283.
Lin, Yi-Lung, Rashmi Madda, Wei-Hsin Sun, Shir-Ly Huang, Shih-Chang Lin. 2014. Interleukin-28 and Human Diseases. Clinical Molecular Medicine 5, 1-2.
Tuan, Nguyen Ngoc, Kyoung Lee, Ju Beom Kang, and Shir-Ly Huang*. 2014. Characterization of a small cryptic plasmid from Pseudomonas nitroreducens strain TX1. Journal of Microbiology 50, 210-215.
Tuan, Nguyen Ngoc, Yi-Chia Chang, Chang-Ping Yu, Shir-Ly Huang*. 2014. Multiple approaches to characterize the microbial community in a thermophilic anaerobic digester running on swine manure: a case study. Microbiological Research 169, 717-724.
Huang, Shir-Ly*, Hsin Chen, Anyi Hu, Nguyen Ngoc Tuan, Chang-Ping Yu. 2014. Draft genome sequence of Pseudomonas nitroreducens strain TX1, which degrades non-ionic surfactants and estrogenic-like alkylphenols. Genome Announcement 2(1), e01262-13.
Lee, Kyoung, Eun Jin Lim, Keun Soo Kim, Shir-Ly Huang, Yaligara Veeranagouda, Bernd H. A. Rehm. 2014. An alginate-like exopolysaccharide biosynthesis gene cluster involved in biofilm aerial structure formation by Pseudomonas alkylphenolia. Applied Microbiology and Biotechnology 98, 4137-4148.
Tuan, Nguyen Ngoc, Yi Wen Lin, Shir-Ly Huang*. 2013. Catabolism of 4-alkylphenols by Acinetobacter OP5: Genetic organization of the oph gene cluster and characterization of alkylcatechol 2, 3-dioxygenase. Bioresource Technology 131, 420-428.
Sokolova, Anna, Shir-Ly Huang, Anthony Duff, Elliot Paul Gilbert, Wen-Hsien Li. 2013. Correlation of thermostability and conformational changes of catechol 2, 3-dioxygenases from two disparate micro-organisms. Biophysical Chemistry 180-181, 145-152.
Wang, Kuen Sheng*, Jung Hsing Chen, Yu Hsiang Huang, Shir-Ly Huang*. 2013. Integrated Taguchi method and response surface methodology to confirm hydrogen production by anaerobic fermentation of cow manure. International Journal of Hydrogen Energy 38, 45-53.
Lin, Ting Hsiang, Chiung Fang Huang, Gia Luen Guo, Wen Song Hwang, Shir-Ly Huang*. 2012. Pilot-scale ethanol production from rice straw hydrolysates using xylose-fermenting Pichia stipitis. Bioresource Technology116, 314-319.
Tuan, Nguyen Ngoc, Hsiao Cheng Hsieh, Yi Wen Lin, and Shir-Ly Huang*. 2011. Analysis of bacterial degradation pathways for long-chain alkylphenols involving phenol hydroxylase, alkylphenol monooxygenase and catechol dioxygenase genes. Bioresource Technology 102, 4232-40.
Lin, Yi-Wen, Gia-Luen Guo, Hsiao-Cheng Hsieh, Shir-Ly Huang*. 2010. Growth of Pseudomonas TX1 on a wide range of octylphenol polyethoxylate concentrations and the formation of dicarboxylated metabolites. Bioresource Technology101, 2853-2859.
Huang, Shir-Ly*, Yuan-Chang Hsu, Chun-Ming Wu, Jeffrey W. Lynnand Wen-Hsien Li. 2010.Thermal effect on the activity and structural conformation of catechol 2, 3-dioxygenases from Pseudomonas putida The Journal of Physical Chemistry B. 114(2), 987-992.
Wu, Li-Cheng, Jorng-Tzong Horng, Shir-Ly Huang, Hsien-Da Huang, Baw-Jhiune Liu. 2006. Detection of discriminative sequence motifs in proteins obtained from prokaryotes grown at various temperatures. J. Computational Chemistry 27, 798-808.

Chen, Hsi-Jien, Gia-Luen Guo, Dyi-Hwa Tseng, Chen-Li Cheng, Shir-Ly Huang*. 2006. Growth factors, kinetics and biodegradation mechanism associated with Pseudomonas nitroreducens TX1 grown on octylphenol polyethoxylates. Environmental Management 80, 279-286.
Chen, Hsi-Jien, Dyi-Hwa Tseng, Shir-Ly Huang*. Biodegradation of octylphenol polyethoxylate surfactant Triton X-100 by selected microorganisms. Bioresource Technology 96, 1483-1491.
Hung, G. C., C. H. Chen, G. L. Guo, and -L. Huang*. 2005. An oxygen consumption enzyme involved in bacterial stress response when grown on non-ionic surfactants. The FEBS Journal 272, Issue Supplement s1, 425.
Huang, Shir-Ly*, Fu-Yung Lin, Chih-Ping Yang. 2005. Microcalorimetric studies of the effects on the interactions of human recombinant interferon-α2a. European J. Pharmaceutical Sciences 24, 545-552.
Huang, Shir-Ly* , Li-Cheng Wu, Han-Kuen Liang, Kuan-Ting Pan, Jorng-Tzong Horngand Ming-Tat Ko. 2004. PGTdb: a database providing growth temperature of prokaryotes. Bioinformatics 20, 276-278.
Huang, Shir-Ly*, Li-Cheng Wu, Hsien-Da Huang, Han-Kuen Liang, Ming-Tat Ko,Jorng-Tzong Horng. 2004. A probabilistic method to correlate ion-pairs with protein thermostability. Applied Bioinformatics 3, 21-29.

Huang, Shir-Ly*, Chia-Jen Yang, Gia-Luen Guo, and S. H. Chou. 2004. Isolation, identification and properties of bacterial strains degrading octylphenol polyethoxylates. Taiwanese Journal of Agricultural Chemistry and Food Science 42, 356-365.
Chen, Hsi-Jien, Shir-Ly Huang, and Dyi-Hwa Tseng. 2004. Aerobic biotransformation of octylphenol polythoxylates surfactant in soil microcosms. Environmental Technology. 25, 201-210.
Huang, Hsien-Da, Jorng-Tzong Horng, Yi-Ming Sun, Ann-Ping Tsou and Shir-Ly Huang. 2004. Identifying transcriptional regulatory sites in the human genome using an integrated system. Nucleic Acids Research 32, 1948-1956.
Horng, J. T., K. C. Hu, L. C. Wu, H. D. Huang, F. M. Lin, -L. Huang, H. C. Lai, and T. Y. Chu. 2004. Identifying the combination of genetic factors that determine susceptibility to cervical cancers. IEEE Transactions on Information Technology in BioMedicine 8, 59-66.
Chen, H.J., D.H. Tseng, -L. Huang, H.C. Hsieh, and G.C. Hung. 2004. Critical review and evaluation of the biodegradation of alkylphenol polyethoxylate surfactant. Bulletin Environ. Engineer. Natl. Central Univ. 10, 1-21.
Horng, Jorng-Tzong, Hsien-Da Huang, Shih-Hsien Wang, Ming-You Chen, Shir-Ly Huang, Jenn-Kang Hwang. 2003. Computing motif correlations in proteins. Journal of Computational Chemistry 24(16), 2032-2043.
Horng, J.T., H.D. Huang, -L. Huang, U.C. Yang, and Y.C. Chang. 2002. Mining putative regulatory elements in promoter regions of Saccharomyces cerevisiae. In Silico Biology 2, 263-273.
Horng, J.T., H.D. Huang, F.M. Lin, L.C. Wu, and -L. Huang. 2002. The repetitive sequence database and mining putative regulatory elements in gene promoter regions. J. Computation Biology 9, 621-640.
Tseng, D.H., G.L. Guo, C.H. Chang, and -L. Huang. 2001. Removal of toluene in gas streams by a fibrous-bed trickling filter. Environmental Technology 22(1), 39-46.
Guo, G.L., D.H. Tseng, and-L. Huang. 2001. Co-metabolic degradation of trichloroethylene by Pseudomonas putida in a fibrous-bed bioreactor. Biotechnology Letters 23, 1653-1657.
Guo, G.L., D.H. Tseng, and-L. Huang. 2000. Bioremediation of chlorinated aliphatic hydrocarbons. Bioindustry 11, 34-45.
Guo, G.L., D.H. Tseng, and -L. Huang. 1998. Critical review and evaluation of cometabolic degradation of chlorinated aliphatic hydrocarbons. Bulletin Environ. Engineer. Natl. Central Univ. 5, 23-38.
Chou, Shan-Yen*, Su-San Chen, Chin-Chung Ho, Shiang-Ling Huang, Tsai-Mien Huang, Ohm-Gue Pan, Chia-Lin Wang, Ying Chen, Hsiao-Hwa Lu, Shih-Hwa Liu, Shir-Ly Huang, and Ren-Shon Chiang. 1996. The syntheses of triazole, sulfur-containing diazole and n-phenylthiatriazole biphenyltetrazoles as potential angiotensin II receptor antagonists. Journal of the Chinese Chemical Society. 43, 83-93.
Yen, F.W., J.-Y. Chiu, C.-L. Wang, H-H Lu, S.H. Liu, -L. Huang and R.S. Chiang. 1994. Synthesis of 3,5-dialkyl-4-substituted-1H-pyrazole derivatives as nonpeptide angiotensin II receptor antagonists. Chinese Pharm. J. 46, 517-534.
Yang, C.P. and -L. Huang*. 1994. Recent development of endothelin receptor antagonists for the modulation of blood pressure. Chemistry (The Chinese Chem. Soc., Taiwan, China) 52, 454-461.
Huang, S.-L. Current trends in the discovery of antihypertensive drugs. Bullet. Biotech. Drug Indust. 2, 25-28.
Huang, S.-L., T.C. Hassell, and W.K. Yeh. 1993. Purification and properties of NADPH-dependent tylosin reductase from Streptomyces fradiae. Biol. Chem. 268, 18987-18993.

計畫

Catabolism of ethoxylated surfactants by Pseudomonas species: Stress responses and roles of alcohol dehydrogenases [假單胞菌株異化界面活性劑：逆境反應與醇類脫氫酶的角色], 主持人, 2020/08/01-2023/07/31, 科技部 (MOST 109-2320-B-010-010-MY3; 3 years)
教育部生醫產業與新農業跨領域人才培育計畫─A類生醫產業與新農業學產研鏈結人才培育計畫–藥品產業創新領域」，協同主持人，2018/3~2022/1，教育部
教育部深耕計畫-國際競爭重點領域人才培育計畫-智能動態系統生物領域

專利

黃雪莉、林世昌、孫維欣。Use of tumor necrosis factor (TNF) receptor-associated factor 7 (TRAF7) as biomarker for systemic lupus erythematosus (SLE), method and kit for detecting of human with SLE. 日本特許第6193806號
孫維欣、黃雪莉、黃旭山。蔥醌[2,1-c][1,2,5]噻二唑-6 11-二酮化物緩解疼痛的應用中華民國 (I533869)
孫維欣、黃雪莉、黃旭山。Indication of naphtho[2,3-F]quinoxaline-7,12-dione compound in alleviating pain. 中華民國 (I533871).
Sun W.H., Huang S.L., HUNAG H.S. Indication of naphtho[2,3-F]quinoxaline-7,12-dione compound in alleviating pain. USA US 9,284,281.
Sun, W.H., Huang, S.L. and Huang, H.S. Indication of anthra[2,1,c][1,2,5]thiadiazole -6,11-dione compound in alleviating pain. USA US 9,192,602.
黃雪莉、林世昌、孫維欣。腫瘤壞死因子受體相關因子７作爲紅斑性狼瘡的生物標記物之用途、偵測人體患有紅斑性狼瘡的方法以及偵測人體患有紅斑性狼瘡的套組. 中華民國 I 502199
Sun, W. H., Huang, S. L. and Huang, H. S. Indication of anthra[2,1,c][1,2,5]thiadiazole-6,11-dione compound in alleviating pain. US 20150258073 A1
Huang, S.L. and Sun, Y. L. Method of Organic Polymer Degradation by Dihydrolipoamide Dehydrogenase. US 8,603,785 B2
Huang, S. L. and Z. Y. Huang. 篩選熱穩定蛋白質之製作方法. 中華民國I 368736
Huang, S. L., D. H. Tseng, and H. J. Chen. Biological method for removing organic polymers. 日本特許第4601394號
Huang, S. L. & G. L. Guo. Method for cleaving ether-linkage of polyethoxylates. 日本特許第4522798號
Huang, S. L. & H. C. Hsieh. Bacterial strain for degradation of organic polymers and environmental hormone. 日本特許第4454471號
Huang, S. L. & G. L. Guo. Method for cleaving ether-linkage of polyethoxylates US7,527,964
Huang, S. L. & Y. L. Sun. 以二氫硫辛醯胺脫氫酶分解有機高分子之方法. 中華民國I309261
Huang, S. L. & H. C. Hsieh. Bacterial strain for degradation of organic polymers and environmental hormones. US7405067B2
Huang, S. L., D. H. Tseng & H. J. Chen. Biological method for removing organic polymers. US 7,332,325B2
Huang, S. L. Bacterial strain for degradation of organic polymers. 日本特許第3967741號
Huang, S. L. & G. L. Guo. 切斷聚氧乙基醇之醚鍵的方法. 中華民國I 265173
Huang, S. L. Bacterial strain for degradation of organic polymers. US7,115,411B2
Huang, S. L. & H. C. Hsieh. 可分解有機高分子化合物與環境賀爾蒙化合物的菌株. 中華民國I258505
Huang, S. L. 可分解有機高分子化合物之菌株. 中華民國I240001
Huang, S. L., D. H. Tseng and H. J. Chen. 可去除有機高分子化合物之生物方法. 中華民國206817
Yen, W. F., Huang, S. L., et al.Novel 3,5-dialkyl-4-substituted-1h-pyrazole derivatives, the method for preparing them and the pharmaceutical compositions comprising them for use as angiotensinⅡ receptor antagonists. 中華民國086064

專書

Tuan, N. N. and L. Huang*. 2012. Design of PCR primers for the mcrA genes detection of methanogen communities. Applied Mechanics and Materials, 135-136, 408-413. ISBN: 978-3-03785-290-3.
黃雪莉. 微生物生理之蛋白質體學研究. 蛋白質體學 (醫藥基因生物技術教學資源中心主編)，pp. 193-214，教育部顧問室生物技術科技教育改善計畫。

實驗室介紹

(I) 環境荷爾蒙之微生物降解

(II) 乳化劑對腸道菌之作用

實驗室成員

現在成員

博士生

105-1 蔡博鈞

107-1 Bui Dinh Lam (裴庭覽)

108-1 楊宜芳

碩士生

洪邦喩 (臨床醫學研究所) (醫學系B組)

張世旻 (臨床醫學研究所) (醫學系B組)

109-1 陳思潔

109-1 吳蕙竹

109-1 Tran Ngoc Yen (陳玉燕)

109-1 Nguyen Thi Hong Ngoc (阮氏紅玉)

110-2 Thang Tran

專題生

109-1 陳乙萱 (藥學系)

110-1 洪嘉和 (醫學系)

畢業碩士生

2019/07 施庭歡

2019/07 林翰揚

2019/07 Phan Thi Ha My (潘氏荷)

2020/01 許雯鈞 (食品安全及健康風險評估研究所)

2021/10 朱國修

新創獎：

https://innoaward.taiwan-healthcare.org/faq_detail.php?REFDOCID=0qtr4aantvcctq08

https://innoaward.taiwan-healthcare.org/news_detail.php?REFDOCTYPID=0qt2u8mwevr2zhqs&REFDOCID=0qt8nkdaprunzjdj

https://sls.ym.edu.tw/files/14-1155-46050,r2-1.php

IC之音：邀請黃雪莉教授分享如何「在校園，就能掌握飛奔而來的國際競爭力」

https://bit.ly/在校園，就掌握飛奔而來的國際競爭力

2019科技部美加亞太區國際科技合作研究成果發表會：

https://youtu.be/fYr2J0BHnnE

黃雪莉 教授

學歷

1990 美國愛荷華大學 (The University of Iowa) 微生物學系 博士

1985 陽明醫學院 微生物及免疫學研究所 碩士

1983 台灣大學 農業化學系 學士

經歷

台灣微生物生態學學會 理事長 (2014-2018)

美國微生物學會 Country Ambassador to Taiwan (2012-2015)

國立陽明交通大學 國際事務處 國際長 (2/2021~11/2021)

國立陽明大學 國際事務處 國際長 (8/2019~1/2021)

國立陽明大學 微生物及免疫學研究所 所長 (2/2017~2/2021)

國立陽明大學 醫學院 微生物學科 科主任 (2/2017~2/2021)

國立中央大學 生命科學系 教授兼系主任 (8/2010~7/2013)

國立中央大學 生物科技與生醫工程中心 教授兼中心主任 (8/2007~7/2013)

生物技術開發中心 製藥計畫 藥物發展組 研究員 (1992~1995)

美國禮萊藥廠 (Eli Lilly & Co.) 博士後研究員 (1991~1992)

獲獎榮譽

指導學生於國內外獲獎超過50人次

(校外獎項)

第十七屆國家新創獎 新創精進獎 (2020)

台灣創新技術博覽會 銀牌獎 (2018)

台北國際發明暨交易展 銅牌獎 (2013)

千里馬盃全國創業競賽 金牌 (2012)

日本舉辦第一屆台灣產學智慧財產展 金賞 (2012)

台北國際發明暨交易展 金牌獎(2011)

第八屆國家新創獎 (2011)

第七屆國家新創獎 (2010)

台灣農業化學會 學術榮譽獎 (2008)

(校內獎項)

國立陽明交通大學 生命科學院 第三季重要期刊論文 (109年度)

醫學學系網路教學評量 優良教師獎狀 (105-109學年度)

醫學系網路教學評量 優良教師琉璃獎座 (107學年度)

研討會主持人/主辦人

2022

The 5th Annual Conference of Taiwan Microbiota Consortium, 2022 ACTMC

(Session chair)

2021

The 4th Annual Conference of Taiwan Microbiota Consortium, 2021 ACTMC

(Session chair)

2020, 2021

Pe-internship “Microbial biotechnology and drug discovery”, NYCU, Taiwan (Organizer)

2020

Taiwan-Australia Symposium on Microbiota Biomedical Exchange- Advances and Applications in Microbial Precision Medicine Technologies, Taiwan (Session chair)

2018, 2019

Summer school and internship “Microbial biotechnology and drug discovery”, NYMU, Taiwan (Organizer)

2018

2018 Annual Meeting of Taiwan Society of Microbial Ecology, Taiwan.

(Symposium chair)

2017

2017 Annual Meeting of Taiwan Society of Microbial Ecology, Taiwan.

(Symposium chair)

2017

Summer school and internship “Frontiers in Microbiome and Cancer Immunology”, NYMU, Taiwan (Organizer)

2017

The 9th Asian Symposium on Microbial Ecology, Korea

(Symposium organizing committee, Session chair)

2016

The 8thAsian Symposium on Microbial Ecology, Taiwan

(Symposium chair, Opening remarks, Keynote session chair)

2015

Cross-Straits Symposium on Environmental Microbiology, Taiwan

(Symposium chair, Opening remarks, Keynote session chair)

2013

The 5th Taiwan-Korea-Japan International Symposium on Microbial Ecology

(Symposium chair, Opening remarks, Keynote session chair)

2010

International Biogas and Biofuel Workshop

(Workshop chair, Opening remarks, Keynote session chair)

2010

International Symposium on Microbial Ecology (Organizer, Keynote session chair)

國際合作學者

Dr. Kyoung Lee

Professor/Director, Department of Bio Health Science, Changwon National University, South Korea

Dr. Nguyen Ngoc Tuan

Lecturer/Assistant Dean, Faculty of Applied Sciences, Ton Duc Thang University, Vietnam

Dr. Marina L. Sidorenko,

Leading Researcher, Soil ecology sector, Federal Scientific Center of the East Asia Terrestrial Biodiversity, FEB RAS, Russia

國際邀請演講

Vietnam

2nd International Conference of Applied Science, Ton Duc Thang University, Ho Chi Minh City (2018)

黃雪莉教授

1990 美國愛荷華大學 (The University of Iowa) 微生物學系博士

1985 陽明醫學院微生物及免疫學研究所碩士

1983 台灣大學農業化學系學士

台灣微生物生態學學會理事長 (2014-2018)

國立陽明交通大學國際事務處國際長 (2/2021~11/2021)

國立陽明大學國際事務處國際長 (8/2019~1/2021)

國立陽明大學微生物及免疫學研究所所長 (2/2017~2/2021)

國立陽明大學醫學院微生物學科科主任 (2/2017~2/2021)

國立中央大學生命科學系教授兼系主任 (8/2010~7/2013)

國立中央大學生物科技與生醫工程中心教授兼中心主任 (8/2007~7/2013)

生物技術開發中心製藥計畫藥物發展組研究員 (1992~1995)

第十七屆國家新創獎新創精進獎 (2020)

台灣創新技術博覽會銀牌獎 (2018)

台北國際發明暨交易展銅牌獎 (2013)

千里馬盃全國創業競賽金牌 (2012)

日本舉辦第一屆台灣產學智慧財產展金賞 (2012)

台北國際發明暨交易展金牌獎(2011)

台灣農業化學會學術榮譽獎 (2008)

國立陽明交通大學生命科學院第三季重要期刊論文 (109年度)

醫學學系網路教學評量優良教師獎狀 (105-109學年度)

醫學系網路教學評量優良教師琉璃獎座 (107學年度)

Madda, Rashmi, Shih-Chang Lin, Wei- Hsin Sun, Shir-Ly Huang. Differential expressions of plasma proteins in systemic lupus erythematosus patients identified by proteomic analysis. Journal of Microbiology, Immunology and Infection 52(5), 816-826.

Tuan, Ngoc Nguyen, Chen-Wei Yeh, Po-Chun Tsai, Kyoung Lee, Shir-Ly Huang. 2016. Transposon mutagenesis identifies genes critical for growth of Pseudomonas nitroreducens TX1 on octylphenol polyethoxylates. Applied and Environmental Microbiology 82(22), 6584-6592.

Mulla, Sikandar I., Anyi Hu, Yuwen Wang, Qian Sun, Shir-Ly Huang, Han Wang and Chang-Ping Yu. 2016. Degradation of triclocarban by a triclosan-degrading Sphingomonas strain YL-JM2C. Chemosphere 144, 292-296.

Wang, Kuen Sheng, Jung Hsing Chen, Yu Hsiang Huang, Shir-Ly Huang. 2013. Integrated Taguchi method and response surface methodology to confirm hydrogen production by anaerobic fermentation of cow manure. International Journal of Hydrogen Energy 38, 45-53.