專任教師 – 免疫學

徐嘉琳教授兼所長
Chia-Lin Hsu

  • 微生物及免疫學研究所 教授
  • 專長領域: 免疫學、神經免疫學、癌症生物學、溶酶體
  • 辦公室位置: 生物醫學大樓(R309)
  • TEL (辦公室): +886-2-28267113
  • TEL (實驗室): +886-2-28267000 ext65619
  • E-mail: clhsu@nycu.edu.tw
  • Web site: https://hdymlab.wixsite.com/website
  • ORCID: 0000-0001-9383-6330

學歷

美國杜克大學 Duke University免疫學研究所博士
國立陽明大學 微生物及免疫學研究所碩士
國立台灣大學 動物學系學士

經歷

國立陽明交通大學微生物及免疫學研究所 教授 (2025~迄今)
國立陽明交通大學微生物及免疫學研究所 副教授 (2019~2025)
台灣免疫學學會 副秘書長(2022~2023)
國立陽明交通大學微生物及免疫學研究所 助理教授 (2013~2019)
Pfizer Center of Therapeutic Innovation, U.S.A., Senior Scientist （2012-2013)
Genentech, U.S.A., Postdoctoral Research Fellow (2007-2012)

獲獎 

  • 2023-2025 Outstanding Research Award
  • 2023 Fellow of Higher Education Accreditation (FHEA)
  • 2023 NYCU Key Publication Award
  • 2022 NYCU Key Publication Award
  • 2022 Chinese Society of Immunology Outstanding Research Award
  • 2021-2023 Outstanding Research Award
  • 2019-2021 Outstanding Research Award
  • 2019 Ta-You Wu Memorial Award
  • 2019 VGH-UST Outstanding Research Award

研討會主持人/主辦人 

  • 2025 American Association of Immunologists, Session Chair
  • 2025 Formosa Immunology Spring Symposium, Session Chair

國際邀請演講 

Date

Conference name/Organization

2025/05/28

*2025 Immunology Joint Symposium, KAIST

2025/05/04

*American Association of Immunology (AAI) 2025

2024/08/30

*Symposium on Endo-Lysosomal ion channels and diseases

2023/08/28

*Glyco26: Glyco-Metabolism & Autophago-lysosomal pathways

2022/11/08

*2022 ICCB & APOCB Joint Meeting

 

論文

  • Ying-Sui Lu, Wei-Chien Hung, Yu-Ting Hsieh, Pei-Yuan Tsai, Tsai-Hsien Tsai, Hsiu-Han Fan, Ya-Gin Chang, Hui-Kuei Cheng, Shen-Yan Huang, Hsin-Chuan Lin, Yan-Hua Lee, Tzu-Hsiang Shen, Bing-Yu Hung, Jin-Wu Tsai, Ivan Dzhagalov, Irene Han-Juo Cheng, Chun-Jung Lin, Yijuang Chern, Chia-Lin Hsu *(2024), Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington’s disease in the mouse model. Brain, Behavior, and Immunity. 2024 Volume 120, August 2024,413-429. https://doi.org/10.1016/j.bbi.2024.06.021
  • Tzu-Yuan Chiu, Chien-Hui Lo, Yi-Hsuan Lin, Yun-Di Lai, Shan-Shan Lin, Ya-Tian Fang, Wei-Syun Huang, Shen-Yan Huang, Pei-Yuan Tsai, Fu-Hua Yang, Weng Man Chong, Yi-Chieh Wu, Hsing-Chen Tsai, Ya-Wen Liu, Chia-Lin Hsu, Jung-Chi Liao, Won-Jing Wang (2023), INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control. Communications Biology. 2023 Sep 5;6(1):911. http://doi: 10.1038/s42003-023-05269-0
  • Hsieh, Y.-T., Tsai, T.-L., Huang, S.-Y., Heng, J.-W., Huang, Y.-C., Tsai, P.-Y., Tu, C.-C., Chao, T.-L., Tsai, Y.-M., Chang, P.-C., Lee, C.-K., Yu, G.-Y., Chang, S.-Y., Dzhagalov, I.L. and Hsu, C.-L.* (2023), IFN-stimulated metabolite transporter ENT3 facilitates viral genome release. EMBO rep e55286.DOI: https://doi.org/10.15252/embr.202255286
  • Ching-Ya Chen, Fang-Yi Chou, Ya-Gin Chang, Chin-Jui Ho, Kuo-Chen Wu, Chia-Lin Hsu, Yijuang Chern, Chun-Jung Lin. Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington’s disease. Neurobiology of Disease. 177 (2023) 106004. DOI: https://doi.org/10.1016/j.nbd.2023.106004
  • Tsung-Lin Tsai, Pei-Yuan Tsai, Ivan L.Dzhagalov, Chia-Lin Hsu*. Protocol for standardized intrathymic injection in mice. STAR protocols. 2023 Jan.DOI: https://doi.org/10.1016/j.xpro.2022.102010
  • Tyng-An Zhou, Hsuan-Po Hsu, Yueh-Hua Tu, Hui-Kuei Cheng, Chih-Yu Lin, Nien-Jung Chen, Jin-Wu Tsai, Ellen A Robey, Hsuan-Cheng Huang, Chia-Lin Hsu, Ivan L Dzhagalov. Thymic macrophages consist of two populations with distinct localization and origin. 2022 Nov. eLife 2022;11:e75148. DOI: https://doi.org/10.7554/eLife.75148
  • Sandra Abril Herrera-Heredia, Hsuan-Po Hsu, Cheng-Yen Kao, Yu-Huan Tsai, Yu Yamaguchi, Axel Roers, Chia-Lin Hsu and Ivan L. Dzhagalov. Heparin is required for the formation of granules in connective tissue mast cells. Frontiers in Immunology, Nov 9, 2022, DOI:http://doi.org/10.3389/fimmu.2022.1000405
  • Tsung-Lin Tsai, Tyng-An Zhou, Yu-Ting Hsieh, Ju-Chu Wang, Hui-Kuei Cheng, Chen-Hua Huang, Pei-Yuan Tsai, Hsiu-Han Fan, Hsing-Kai Feng, Yu-Chia Huang, Chen-Ching Lin, Chao-Hsiung Lin, Chih-Yu Lin, Ivan L. Dzhagalov, Chia-Lin Hsu*. Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress. Cell reports, Vol. 40, ISSUE 2, 111065, JULY 12, 2022. DOI:https://doi.org/10.1016/j.celrep.2022.111065 *corresponding author
  • Fan HH, Tsai TL, Dzhagalov I, Hsu CL*. Evaluation of Mitochondria Content and Function in Live Cells by Multi-color Flow Cytometric Analysis. Methods in Molecular Biology, 2021, Vol. 2276: 203-213. doi: 0.1007/978-1-0716-1266-8_15  *corresponding author
  • Hsuan-Po Hsu, Yun-Tzu Chen, Yu-Ying Chen, Chih-Yu Lin, Po-Yu Chen, Shio-Yi Liao, Ciara Christianne Y. Lim, Yu Yamaguchi, Chia-Lin Hsu, Ivan L. Dzhagalov. Heparan sulfate is essential for thymus growth. Journal of Biological Chemistry, Feb, 2021, S0021-9258(21)00192-7,
    DOI: https://doi.org/10.1016/j.jbc.2021.100419
  • Feng HK, CF Chu, Sun KH, Hsu CL, Dzhagalov I. Examination of Fas-induced apoptosis of murine thymocytes in thymic tissue slices reveals that Fas is dispensable for negative selection. Cell Dev. Biol., 21 October 2020 DOI: https://doi.org/10.3389/fcell.2020.586807
  • Hsu KH, Wei CW, Su YR, Chou T, Lin YL, Yang FC, Tsou AP, Hsu CL, Tseng PH, Chen NJ, Jeng KS, Leu CM. Upregulation of RelB in the miR-122 knockout mice contributes to increased levels of proinflammatory chemokines/cytokines in the liver and macrophages. Immunology Letters, 2020 Oct;226:22-30.  DOI: http://doi.org/10.1016/j.imlet.2020.06.015.
  • Zhou TA, Hsu CL, Dzhagalov IL*. Testing the Efficiency and Kinetics of Negative Selection Using Thymic Slices. Methods Mol Biol. 2020;2111:205-219. DOI: https://doi.org/10.1007/978-1-0716-0266-9_17.
  • Hsu CL*, Dzhagalov I. Metabolite Transporters—The Gatekeepers for T cell Metabolism. Immunometabolism. 2019;1:e190012. DOI: https://doi.org/10.20900/immunometab20190012 *corresponding author
  • Hsu CL*, Dzhagalov I, Niu DM*. “Response to Chung et al.” Genetics in Medicine Jan 22, 2019 * co-corresponding author
  • Wei CW, Lee CY, Lee DJ, Chu CF, Wang JC, Wang TC, Jane WN, Chang ZF, Leu CM, Dzhagalov I, Hsu CL*. Equilibrative Nucleoside Transporter 3 regulates T cell homeostasis by coordinating lysosomal function with nucleoside availability. Cell Reports 23, 2018: 2330-2341. doi:10.1016/j.celrep.2018.04.077  *corresponding author
  • Hsu MJ, Chang FP, Lu YH, Hung SC, Wang YC, Yang AH, Lee HR, Sung SH, Wang YF, Yu WC, Hsu TR, Huang, Chang SK, Dzhagalov I, Hsu CL*, Niu DM*. Identification of Lysosomal and Extralysosomal Globotriaosylceramide (Gb3) Accumulations Before the Occurrence of Typical Pathological Changes in the Endomyocardial Biopsies of Fabry Disease Patients. Genetics in Medicine 06 June 2018: 21, 224-232 doi:10.1038/s41436-018-0010-z * co-corresponding author
  • Chuang TY, Cheng AJ, Lan TY, Huang IH, Shiau CW, Hsu CL, Liu YW, Tseng PH, Chang ZF, Kuo JC. Suppression of LPS-induced inflammatory responses by the hydroxyl groups of dexamethasone. Oncotarget 2017 Jul 25;8(30):49735-49748
  • Hsu TR, Hung SC, Chang FP, Yu WC, Sung SH, Hsu CL, Dzhagalov I, Yang CF, Chu TH, Lee HJ, Lu YH, Chang SK, Liao HC, Lin HY, Liao TC, Lee PC, Li HY, Yang AH, Ho HC, Chiang CC, Lin CY, Desnick RJ, Niu DM. Later Onset Fabry Disease, Cardiac Damage Progress in Silence, Journal of the American College of Cardiology 68, 2016: 2554-2563.
  • Hsu CL, Lin W, Seshasayee D, Chen YH, Ding X, Lin Z, Suto E, Huang Z, Lee WP, Park H, Xu M, Sun M, Rangell L, Lutman JL, Ulufatu S, Stefanich E, Chalouni C, Sagolla M, Diehl L, Fielder P, Dean B, Balazs M and Martin F. Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Macrophage Lysosome Functions and Homeostasis. Science, 6 January 2012: 89-92.
  • Chung E, Hsu CL, and Kondo M. Constitutive MAP kinase activation in hematopoietic stem cells induces myelo-proliferative neoplasm. PLos One, 2011;6(12):e28350. Epub 2011 Dec 2
  • Hsu CL, and Kondo M.To be or not to be: that is the question—Lineage Commitment in Hematopoiesis. Current Immunology Reviews, 2007 Nov:3 (4) pp. 258-268(11)
  • Hsu CL, Kikuchi K, Kondo M. Activation of MEK/ERK signaling is involved in myeloid lineage commitment during hematopoiesis. Blood, 2007 Sep 1;110(5):1420-8. Epub 2007 May 29.
  • Hsu CL, King-Fleischman AG, Lai AY, Matsumoto Y, Weissman IL, Kondo M. Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):672-7.
  • Kikuchi K, Lai AY, Hsu CL, Kondo M. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. J Exp Med. 2005 Apr 18;201(8):1197-203.
  • He YW, Li H, Zhang J, Hsu CL, Lin E, Zhang N, Guo J, Forbush KA, Bevan MJ. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol. 2004 Jan;5(1):88-97.

書籍

  1.  Fan HH, Tsai TL, Dzhagalov I, Hsu CL*. Evaluation of Mitochondria Content and Function in Live Cells by Multi-color Flow Cytometric Analysis. Methods in Molecular Biology, 2021, Vol. 2276: 203-213. doi: 0.1007/978-1-0716-1266-8_15  *corresponding author

  2. Zhou TA, Hsu CL, Dzhagalov IL*. Testing the Efficiency and Kinetics of Negative Selection Using Thymic Slices. Methods Mol Biol. 2020;2111:205-219. doi: 10.1007/978-1-0716-0266-9_17.

計畫

科技部、榮台聯大、嚴慶齡基金會、陽明交通大學腫瘤卓越中心、陽明交通大學防疫中心

專利

Provisional Pattern Application: Sindbis virus DNA-based vaccine

研究方向 

  • 免疫細胞功能的代謝調控Metabolic regulation of immune cell functions
  • 溶酶體在免疫細胞中的多重角色Multifaceted roles of lysosomes in immune cells
  • 先天免疫的感知與調控Innate immunity sensing and regulation
  • 徐嘉琳老師實驗室致力於研究代謝物轉運蛋白如何在正常與疾病狀態下，對免疫系統的活化與發育產生反應並提供支持。
    The Hsu lab investigates how metabolite transporters respond and support immune system activation and development under both normal and disease conditions

實驗室成員 

Postdoctoral fellow:

  • Yu-Ting Hsieh (2025- Present)

Ph.D. student:

  • Hsiu-Han Fan(2019-Present)
  • Pei-Yuan Tsai(2021-Present)
  • Yu-Hsuan Sung (2025-Present)

M.S. student:

  • Chun-Yu Chen, Bo-Wei Lin, Shuan-Chen Lin (2025 graduate)
  • Shu-Yu Liu, Jie Wang (2026 graduate)
  • Dong-Chi Yeh, Hsin-Wei Huang (2027 graduate)

實驗室照片 

2025畢業典禮實驗室成員合照

2025暑期實習生結業以及碩士班新生加入實驗室

2025 微免所環保永續紙飛機大賽得獎隊伍