專任教師 – 免疫學

陳念榮教授
Nien-Jung Chen

  • 微生物及免疫學研究所 教授
  • 專長領域:免疫學、發炎反應調控、轉殖小鼠疾病模式 (自體免疫腸道疾病、腎臟發炎、癌症等)
  • 辦公室位置: 生物醫學大樓(R307)
  • TEL (辦公室): +886-2-28267106
  • TEL (實驗室): +886-2-28267000 ext 65618
  • E-mail: njchen@nycu.edu.tw
  • ORCID: 0000-0002-9441-4049

學歷

國立陽明大學 微生物及免疫學研究所 博士 (1994-2000)
國立陽明大學 微生物及免疫學研究所 博士後研究員 (2000-2002)
The Campbell family Institute for Breast Cancer Research/ Ontario Cancer Institute (OCI)/ University Health Network (UHN)/ University of Toronto博士後研究員(2002-2007)

經歷

國立陽明交通大學微生物及免疫學研究所 代理所長 (2024.06~2025.05)
國立陽明交通大學微生物及免疫學研究所 所長 (2021.02~2023.05)
國立陽明大學 研發處 計畫業務組 組長 (2015.01~2021)
國立陽明大學微生物及免疫學研究所 教授 (2024.02~迄今)
國立陽明大學微生物及免疫學研究所 副教授 (2014.08~2024.01)
國立陽明大學 微生物及免疫學研究所 助理教授 (2007.12~2014.07)

獲獎榮譽

國立陽明大學生科院優良教師 (2010)
國立陽明大學 醫學系網路教學評量 優良教師獎狀 2008-2011)
國立陽明大學 醫學系網路教學評量 優良教師琉璃獎座 (2012)
中華民國免疫學會 財團法人沈水德翁文教基金會 學術論文獎 (2014)

論文

  1. Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes. Jiang Z, Li H, Schroer SA, Voisin V, Ju Y, Pacal M, Erdmann N, Shi W, Chung PED, Deng T, Chen NJ, Ciavarra G, Datti A, Mak TW, Harrington L, Dick FA, Bader GD, Bremner R, Woo M, Zacksenhaus E. EMBO J. 2022 Feb 15;41(4):e106825. doi: 10.15252/embj.2020106825. Epub 2022 Jan 13. PMID: 35023164
  2. PD-L1 Expression in Monocytes Correlates with Bacterial Burden and Treatment Outcomes in Active Pulmonary Tuberculosis. Pan SW, Shu CC, Huang JR, Lee CC, Tseng YH, Hung JJ, Hsu PK, Chen NJ, Su WJ, Feng JY, Chen YM. Int J Mol Sci. 2022 Jan 30;23(3):1619. doi: 10.3390/ijms23031619.
  3. Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans. Lo TH, Chen HL, Yao CI, Weng IC, Li CS, Huang CC, Chen NJ, Lin CH, Liu FT*. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2026246118. doi: 10.1073/pnas.2026246118.PMID: 34301890
  4. Hypoxic mesenchymal stem cells ameliorate acute kidney ischemia-reperfusion injury via enhancing renal tubular autophagy. Tseng WC, Lee PY, Tsai MT, Chang FP, Chen NJ, Chien CT, Hung SC, Tarng DC*. Stem Cell Res Ther. 2021 Jun 28;12(1):367. doi: 10.1186/s13287-021-02374-x.PMID: 34183058
  5. An oral absorbent, AST-120, restores vascular growth and blood flow in ischemic muscles in diabetic mice via modulation of macrophage transition. Huang HL, Kuo CS, Chang TY, Chou RH, Chen IC, Yang FC, Chen NJ, Lin SJ, Wu CC, Huang PH*. J Mol Cell Cardiol. 2021 Jun;155:99-110. doi: 10.1016/j.yjmcc.2021.03.001. Epub 2021 Mar 10.PMID: 33713645
  6. Efficient conversion of human induced pluripotent stem cells into microglia by defined transcription factors. Chen SW, Hung YS, Fuh JL, Chen NJ, Chu YS, Chen SC, Fann MJ, Wong YH*. Stem Cell Reports. 2021 May 11;16(5):1363-1380. doi: 10.1016/j.stemcr.2021.03.010. Epub 2021 Apr 8.PMID: 33836143
  7. TREM-1 enhances Mycobacterium tuberculosis-induced inflammatory responses in macrophages. Feng JY, Su WJ, Chuang FY, Pan SW, Yeh YC, Lin YY, Chen NJ*., MICROBES AND INFECTION 2020 Oct.; S1286-4579(20):30179-9 (*corresponding author)
  8. Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation. Tseng WC, Tsai MT, Chen NJ, Tarng DC. Int J Mol Sci. 2020 Aug 19;21(17): E5966.
  9. Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis. Chen WC, Chen NJ, Chen HP, Yu WK, Su VY, Chen H, Wu HH, Yang KY. Int J Mol Sci. 2020 Jul 2;21(13):4735.
  10. Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy. Chou YJ, Lin CC, Dzhagalov I, Chen NJ, Lin CH, Lin CC, Chen ST, Chen KH, Fu SL. Sci Rep. 2020 May 21;10(1):8422.
  11. Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis. Kuo CL, Chou HY, Chiu YC, Cheng AN, Fan CC, Chang YN, Chen CH, Jiang SS, Chen NJ, Lee AY. Cancer Lett. 2020 Apr 1;474:138-150.
  12. Upregulation of RelB in the miR-122 knockout mice contributes to increased levels of proinflammatory chemokines/ cytokines in the liver and macrophages. Hsu KH, Wei CW, Su YR, Chou T, Lin YL, Yang FC, Tsou AP, Hsu CL, Tseng PH, Chen NJ, Jeng KS, Leu CM. Immunol Lett. 2020 Jul 2; 226: 22-30.
  13. TREM-1-dependent M1 macrophage polarization restores in(*corresponding author)testinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells. Yang FC, Chiu PY, Chen Y, Mak TW, Chen NJ*. J Biomed Sci. 2019 Jun 12;26(1):46. (*corresponding author)
  14. Induced Pluripotent Stem Cells Regulate Triggering Receptor Expressed on Myeloid Cell-1 Expression and the p38 Mitogen-Activated Protein Kinase Pathway in Endotoxin-Induced Acute Lung Injury. Su VY, Yang KY, Chiou SH, Chen NJ, Mo MH, Lin CS, Wang CT. Stem Cells. 2019 May;37(5):631-639.
  15. Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM-1 levels. Feng JY, Su WJ, Pan SW, Yeh YC, Lin YY, Chen NJ*. Sci Rep. 2018 May 29;8(1):8223. (*corresponding author)
  16. CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra. Cheng AC, Yang KY, Chen NJ, Hsu TL, Jou R, Hsieh SL, Tseng PH. PLoS One. 2017 Oct 24;12(10): e0186780.
  17. CLEC5A is a critical receptor in innate immunity against Listeria infection. Chen ST, Li FJ, Hsu TY, Liang SM, Yeh YC, Liao WY, Chou TY, Chen NJ, Hsiao M, Yang WB, Hsieh SL. Nat Commun. 2017 Aug 21;8(1):299.
  18. Triggering receptor expressed on myeloid cells-1 (TREM-1) deficiency augments BAFF production to promote lupus progression. Liu CJ, Tsai CY, Chiang SH, Tang SJ, Chen NJ, Mak TW, Sun GH, Sun KH. J Autoimmun. 2017 Mar;78:92-100.
  19. Attenuation of Tubular Injury and Renal Fibrosis by TI-HU-YIN via Reduction in Transforming Growth Factor-β1 Expression in Unilateral Ureteral Obstruction Mice. Tarng DC*, Liu IS, Lin LC, Chen NJ*. Chin J Physiol. 2015 Dec 31;58(6):367-76. (*corresponding author)
  20. Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection. Weng SC, Shu KH, Wu MJ, Wen MC, Hsieh SL, Chen NJ*, Tarng DC*. Sci Rep. 2015 Sep 3;5:12769. (*corresponding author)
  21. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation. Chen IT, Hsu PH, Hsu WC, Chen NJ, Tseng PH. Sci Rep. 2015 Jul 20;5:12300.

實驗室介紹

  1. We established several TREM gene deficient mouse models to investigate the role of TREM in the immunity against Klebsiella pneumoniae oral-infection, especially involves the intestinal barrier against bacteria translocation.
  2. We study the role of TREM members in the aseptic inflammation in kidneys by using UUO mouse CKD model. Intriguingly, we found that TREM1 is crucial for the pathogenesis of UUO-mediated nephritis, mainly through the contribution of TREM1 to the inflammatory macrophage polarization. By contrast, TREM2 play roles in negative modulating Th17-mediated responses in kidney inflammation upon UUO.
  3. We examine the role of TREM2 in the pathogenesis of Aβ-stimulated neuroinflammation in J20 transgenic animal model. TREM2 mediates Aβ-triggered iNOS and NO induction, further involving in regulating Aβ deposition and clearance in microglia.
  4. We examine the role of TREM1 in DSS-mediated inflammatory bowel disease model. TREM1 deficiency leads to an imbalance between cytokines produced by innate lymphoid cell (ILC)-3 (IL-17 and IL-22) and those by ILC-2 (IL-33 and IL-13), suggesting a crucial role of TREM1 in modulating the colon intestinal barrier and ILC functions.
  5. A reporter mice model is constructed and established in our group to monitor the Kinect of M1/M2 polarization and in vivo depletion of specific M1/M2 cells.

實驗室成員

現在成員

博士生
林慶政
李健榕
陳沛谷

碩士生
鄭奕晴
賴子茹
王岳翎
于全慧
陳怡廷
林弓威
何冠陞

實驗室照片