Po-Chen Hsu 許博琛助理教授 - 國立陽明交通大學微生物及免疫學研究所

許博琛助理教授

微生物及免疫學研究所助理教授
專長領域:模式與致病酵母菌生物學、演化遺傳與基因體學、分子演化
辦公室位置: 生物醫學大樓(R405)
TEL (辦公室): +886-2-28267107
TEL (實驗室): +886-2-28267000 ext 65622
E-mail: pchsu2025@nycu.edu.tw
Website: under construction
ORC ID: https://orcid.org/0000-0002-9425-8154
履歷: CV_Po-Chen Hsu_20250307
酵母菌分子遺傳與演化實驗室介紹

主要經歷論文著作與計畫實驗室

學歷

Ph.D. (2007−2013) in Molecular and Cellular Biology

Institute of Molecular and Cellular Biology, National Tsing-Hua University, Taiwan. / Chung-Yu Lan (藍忠昱老師)’s Lab.

M.S. program (2006−2007), then transfer into the Direct-Ph.D program.

Institute of Molecular and Cellular Biology, National Tsing-Hua University, Taiwan. / Chung-Yu Lan(藍忠昱老師)’s Lab.

Undergraduate researcher/bachelor’s thesis (2004−2006)

Institute of Molecular Medicine, National Tsing-Hua University, Taiwan./ Kuan Rong Lee (李寬容老師)’s Lab.

經歷

國立陽明大學微生物及免疫學研究所助理教授 (2025~迄今)
中央研究院分子生物研究所資深專案博士後研究員 (2020-2025)
中央研究院分子生物研究所博士後研究員 (2013-2020)

獲獎榮譽

2022 NSTC Academic Research Award for Postdoc Researchers (國科會111年度博士後研究人員學術研究獎)

論文

Hsu, P.-C.*, Lu, T.-C., Hung, P.-H., and Leu, J.-Y.* (2024) Protein moonlighting by a target gene dominates phenotypic divergence of the Sef1 transcriptional regulatory network in yeasts. Nucleic Acids Res. 52(22):13914-13930. (* co-corresponding author) (6/313 in Biochemistry & Molecular Biology, 2023 JCR)
Hsu, P.-C.*, Cheng, Y.-H., Liao, C.-W., Litan, R.R.R., Jhou, Y.-T., Opoc, F.J.G., Amine, A.A.A., and Leu, J.-Y. (2023) Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network. EMBO Reports 24(6):e56019 (* corresponding author)(60/313 in Biochemistry & Molecular Biology, 2023 JCR)
Chou, J.-Y.*, Hsu, P.-C., and Leu, J.-Y.* (2022) Enforcement of postzygotic species boundaries in the fungal kingdom. Microbiology and molecular biology reviews 86(4), e0009822 (Review article)
Hsu, P.-C.*, Lu, T.-C., Hung, P.-H., Jhou, Y.-T., Amine, A.A.A., Liao, C.-W., Leu, J.-Y.* (2021) Plastic Rewiring of Sef1 Transcriptional Networks and the Potential of Nonfunctional Transcription Factor Binding in Facilitating Adaptive Evolution. Molecular Biology and Evolution 38(11): 4732-4747 (* co-corresponding author) (4/54 in Evolutionary Biology, 2023 JCR)
Amine, A.A.A., Liao, C.-W., Hsu, P.-C., Opoc, F.J.G., Leu, J.-Y. (2021) Experimental evolution improves mitochondrial genome quality control in Saccharomyces cerevisiae and extends its replicative lifespan. Current Biology 31(16):3663-3670e4 (3/109 in Biology, 2023 JCR)
Chen, Y.-Y., Chao, C.-C., Liu, F.-C., Hsu, P.-C., Chen, H.-F., Peng, S.-C., Chuang, Y.-J., Lan, C.-Y., Hsieh, W.-P., and Wong, D.S.-H.* (2013) Dynamic transcript profiling of Candida albicans infection in zebrafish: a pathogen-host interaction study. PLoS One 8(9):e72483
Hsu, P.-C., Chao, C.-C., Yang, C.-Y., Ye, Y.-L., Liu, F.-C., Chuang, Y.-J., and Lan, C.-Y.* (2013) Diverse Hap43-independent functions of Candida albicans CCAAT-binding complex. Eukaryot Cell 12(6):804-15
Tsai, P.-W., Chen, Y.-T., Hsu, P.-C., and Lan, C.-Y.* (2013) Study of Candida albicans and its interactions with the host: A mini-review. BioMedicine 3:51-64
Hsu, P.-C., Yang, C.-Y., and Lan, C.-Y.* (2011) Candida albicans Hap43 is a repressor induced under low-iron conditions and is essential for iron-responsive transcriptional regulation and virulence. Eukaryot Cell 10(2):207-225
Chao, C.-C., Hsu, P.-C., Jen, C.-F., Chen, I.-H., Wang, C.-H., Cham, H.-C., Tsai, P.-W., Tung, K.-C., Wang, C.-H., Lan, C.-Y.*, and Chuang, Y.-J.* (2010) Zebrafish as a model host for Candida albicans Infect Immun 78(6): 2512-2521

Research interests

我們利用各種酵母菌為模式生物，配合遺傳學、分子生物學、生物化學，與系統生物學的研究方法來回答微生物學領域，醫學領域，與演化生物學領域的問題。

Yeast Pathogenesis (酵母菌病源體的致病機制)
Mitochondrial genome quality control & disease (粒線體基因體品管機制與疾病的關聯)
Transcriptional rewiring (轉錄因子調控網路重組的分子機制)
Experimental evolution (實驗室內的酵母菌人工演化)
Molecular basis of complex traits (受多重因子影響性狀之分子機制)
Pleiotropy (酵母菌基因多效性)
Cell density-dependent phenotypes (細胞濃度依賴性之酵母菌表現型)

參考報導

發現新的轉錄因子調控網路演化軌跡

https://www.sinica.edu.tw/News_Content/36/2829

許博琛 助理教授

學歷

經歷

獲獎榮譽

論文

Research interests

許博琛助理教授