蔡雨寰 助理教授
- 微生物及免疫學研究所 助理教授
- 專長領域:感染症模型、細菌生理與訊息傳遞、黏膜免疫學
- 辦公室位置: 生物醫學大樓(R405)
- TEL (辦公室): +886-2-28267107
- TEL (實驗室): +886-2-28267000 ext 65622
- E-mail: yuhuan.tsai@nycu.edu.tw
- https:0000-0002-1374-2359
學歷
巴斯德-巴黎大學國際博士學程 (巴黎第七大學，法國巴黎巴斯德研究院) 博士 2014
台灣大學 醫學檢驗暨生物技術學 碩士 2008
台灣大學 醫學檢驗暨生物技術學 學士 2006
經歷
國立陽明大學 微生物及免疫學研究所 助理教授 (2018~迄今)
獲獎榮譽
國立陽明交通大學生命科學院教學傑出教師 (109學年度)
論文
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Maudet C, Kheloufi M, Levallois S, Gaillard J, Huang L, Gaultier C, Tsai YH, Disson O, Lecuit M. Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence. Nature. 2022 (accepted)
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Huang YT, Kuo YW, Lee MR, Tsai YH, Teng LJ, Tsai MS, Liao CH, Hsueh PR. Clinical and molecular epidemiology of human listeriosis in Taiwan. Int J Infect Dis. 2021 Jan 28;104:718-724.
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Guo J, Ning XQ, Ding JY, Zheng YQ, Shi NN, Wu FY, Lin YK, Shih HP, Ting HT, Liang G, Lu XC, Kong JL, Wang K, Lu YB, Fu YJ, Hu R, Li TM, Pan KS, Li XY, Huang CY, Lo YF, Chang IY, Yeh CF, Tu KH, Tsai YH, Ku CL, Cao CW. Anti-IFN-γ autoantibodies underlie disseminated Talaromyces marneffei J Exp Med. 2020 Dec 7;217(12):e20190502.
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Tsai YH* and Chen WL. Host lipid rafts as the gates for Listeria monocytogenes infection: a mini-review. Front Immunol. 2020 Aug 11;11;1666 *lead contact
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Gu ZQ, Tseng KY, and Tsai YH*. Candida gut commensalism and inflammatory disease. Medicine in Microecology 2020 Mar;3:100008 * lead contact
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Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, and Young JD. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obes. (Lond) 2018 Feb;42(2):231-243
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Wei CF*, Tsai YH*, Tsai SH, Lin CS, Chang CJ, Lu CC, Huang HC, Lai HC. Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development. Biochem Biophys Res Commun. 2017 Jul 15;489(1):70-75 *co-first author
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Lin CS*, Tsai YH*, Chen CC, Chang WW, Lin YC, Chang CJ, Tseng SF, Wu TR, Lu CC, Horng JT, Martel J, Ojcius DM, Young JD, Lai HC. An iron detection system determines bacterial swarming initiation and biofilm formation. Sci Rep. 2016 Nov 15;6:36747 *co-first author
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Maury MM*, Tsai YH*, Charlier C, Touchon M, Chenal-Francisque V, Leclercq A, Criscuolo A, Gaultier C, Rousse S, Brisabois A, Disson O, Rocha EP, Brisse S, Lecuit M. Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nat Genet. 2016 Mar 48(3)308-13 *co-first author
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Gessain G, Tsai YH, Travier L, Bonazzi M, Grayo S, Cossart P, Charlier C, Disson O, Lecuit M. PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes. J Exp Med. 2015 Feb 9;212(2):165-83.
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Tsai YH, Disson O, Bierne H, Lecuit M. Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses. PLoS Pathog 2013;9(5):e1003381
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Lai HC, Chang CJ, Yang CH, Hsu YJ, Chen CC, Lin CS, Tsai YH, Huang TT, Ojcius DM, Tsai YH, Lu CC. Activation of NK cell cytotoxicity by the natural compound 2,3-butanediol. J Leukoc Biol. 2012 Oct;92(4):807-14
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Tsai YH, Wei JR, Lin CS, Chen PH, Huang S, Lin YC, Wei CF, Lu CC, Lai HC. RssAB signaling coordinates early development of surface multicellularity in Serratia marcescens. PLoS ONE 2011;6(8):e24154
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Lin CS, Horng JT, Yang CH, Tsai YH, Su LH, Wei CF, Chen CC, Hsieh SC, Lu CC, Lai HC. RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens. Infect Immun. 2010 Nov;78(11):4870-81
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Hsieh SC, Lu CC, Horng YT, Soo PC, Chang YL, Tsai YH, Lin CS, Lai HC. The bacterial metabolite 2,3-butanediol ameliorates endotoxin-induced acute lung injury in rats. Microbes Infect. 2007 Oct;9(12-13):1402-9
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Soo PC, Horng YT, Lai MJ, Wei JR, Hsieh SC, Chang YL, Tsai YH, Lai HC. Pirin regulates pyruvate catabolism by interacting with the pyruvate dehydrogenase E1 subunit and modulating pyruvate dehydrogenase activity. J Bacteriol. 2007 Jan;189(1):109-18
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Wei JR, Soo PC, Horng YT, Hsieh SC, Tsai YH, Swift S, Withers H, Williams P, Lai HC. Regulatory roles of spnT, a novel gene located within transposon TnTIR. Biochem Biophys Res Commun. 2006 Sep 29;348(3):1038-46
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Wei JR, Tsai YH, Horng YT, Soo PC, Hsieh SC, Hsueh PR, Horng JT, Williams P, Lai HC. A mobile quorum-sensing system in Serratia marcescens. J Bacteriol. 2006 Feb;188(4):1518-25
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Wei JR, Tsai YH, Soo PC, Horng YT, Hsieh SC, Ho SW, Lai HC. Biochemical characterization of RssA-RssB, a two-component signal transduction system regulating swarming behavior in Serratia marcescens. J Bacteriol. 2005 Aug;187(16):5683-90
實驗室介紹
我們實驗室著重於利用顯微技術研究微生物與宿主組織交互作用，並利用黏膜共生真菌作為模型探討這樣的交互作用對微生物共生或感染的影響。我們亦同時與台灣疾管署、位於巴黎巴斯德研究中心的世界衛生組織李斯特菌歐洲合作實驗室、以及國內各大醫學中心合作，利用基因體學研究李斯特菌全球演化，並進一步結合動物模型及實驗室各種離體模型以了解李斯特菌症。我們歡迎有志於學習並從事感染症研究的學生加入我們的團隊。
實驗室成員
Feb. 2022 更新
博士生 (加入時間)
曾國堯 (2019)
顧子奇 (2020, 2018-2020 as a Master student in the lab)
鄭文豪 (2020)
陳瑋璘 (MMP PhD program; 2021, 2019-2021 as a Master student in the lab)
碩士生
張岱玲 (2020)
蘇于庭 (2020)
翁文彥 (2021)
林冠廷 (2021)
陳婷暄 (2021)
大學部
王安妮 (2021)
實驗室照片
2021年9月慶祝教師節
