合聘教師

謝世良教授
Shie-Liang Hsieh

  • 職稱: 特聘研究員, 國家衛生研究院免疫醫學研究中心主任
  • 專長領域：Host-Pathogen Interactions, Cancer immunology, Tissue repair and regeneration, Immunoageing
  • 辦公室位置： 生醫工程館 R554
  • 電話(辦公室) ： 67220
  • 電話(實驗室) ： 65958
  • Email:  slhsieh@nhri.edu.tw
  • 個人網頁 ：網頁
  • ORCID： https://orcid.org/0000-0001-9415-346X

 

 

學歷

  • D., National Yang-Ming University, Taiwan, 1984
  • Phil., University of Oxford, UK, 1992
  • Postdoctoral fellow, Stanford University, USA, 1993

經歷

  • D., National Yang-Ming University, Taiwan, 1984
  • Phil., University of Oxford, UK, 1992
  • Johnson & JohnsonPostdoctoral fellow, Stanford University, USA, 1993
  • Director, Institute of Clinical Medicine, National Yang-Ming University, Taiwan, 2010-2013
  • Distinguished Professor, Department of Microbiology and Immunology, National Yang-Ming University, Taiwan, 2007-2013
  • Professor, Department of Microbiology and Immunology, National Yang-Ming University, Taiwan, 2001-2013
  • Director, Immunology Research Center, National Yang-Ming University, Taiwan, 2000-2013
  • Director, Immunology Research Center, Taipei Veterans’ General Hospital, Taiwan, 2005-2013
  • Adjunct Research Fellow, Academia Sinica, Taiwan, 2009-2013
  • Director, IRB on Biomedical Science Research, Academia Sinica, Taiwan, 2018-2022
  • Distinguished Professor, Academia Sinica, Taiwan, 2013-present
  • Joint Appointment Professor, Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taiwan, 2013-present
  • Adjunct Professor, National Taiwan University, Taiwan, 2014-present
  • Members, IRB on Biomedical Science Research, Academia Sinica, Taiwan, 2022- present
  • Joint Appointment Distinguished Investigator / Director, National Health Research Center, Taiwan, 2022-present

獲獎

  • 2021    Outstanding Research Fellow award from the Ministry of Science and Technology (科技部109年度傑出特約研究員)
  • 2020    The 18th Z. Hsu Scientific Chair Professor (第十八屆有庠科技講座)
  • 2013    The 8thSession TienTe Lee Award (第八屆永信李天德卓越醫藥科技獎)
  • 2012    The 16thNational Chair Professor Award, Ministry of Education (教育部第16屆國家講座)
  • 2010    Outstanding Researcher Award from the National Science Council (國科會傑出獎)
  • 2009    The 4thLong-Term Award from Acer Foundation (第四屆宏碁基金會龍騰微笑得獎人)
  • 2009    The 53thAcademic Achievement Award, Ministry of Education (教育部第53屆學術獎)
  • 2009    Tsungming Tu Award, Taiwan Medical Society (台灣醫學會杜聰明獎)
  • 2008    The 18thOutstanding research Achievement to National Health, “Ming-Ning Wang Memorial Foundation” (第十八屆王民寧獎-傑出貢獻獎得獎人)
  • 2004    The 1stOutstanding Alumni, National Yang-Ming University (第一屆陽明大學 傑出校友)
  • 2003    Outstanding Researcher Award from the National Science Council (國科會傑出獎)
  • 1999    Outstanding Researcher Award from the National Science Council (國科會傑出獎)
  • 1992    Irvington Medial Foundation post-doctoral fellowship ‘Robert Wood Johnson Fellow
  • 1989    Oversea Research Scholarship (ORS) from the University of Oxford
  • 1989    Oversea PhD studentship from the Ministry of Education, Taiwan

研討會主持人/主辦人

  • 主辦人: 第二屆 NHRI-NYCU-Harvard-KAIST 免疫學會 (2025-5/13 ~ 5/16)
  • 主辦人: 第九屆亞太免疫學會FIMSA 2024 (https://www.fimsa2024.org)
  • 主辦人: Keystone Symposium 2019 (Innate Immune Receptors: Roles in Immunology and Beyond)

國際邀請演講

  • 第ㄧ屆 NHRI-NYCU-Harvard-KAIST 免疫學會 (2025-5/13 ~ 5/16, Korea)
  • 2025 International HBV conference (2025 9/8-9/12 Berlin, Germany)

論文

  • Huang JY, Sung PS, Hsieh SL* (2025) Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection. Frontier Immunology 15: 1513713. doi: 10.3389/fimmu.2024.1513713
  • Liao TL, Chen DY, Hsieh SL, Yang YY, Chen YM, Tang KT, Chang CH, Yang SS. Platelet-derived mitochondria regulate lipid metabolism in nonalcoholic steatohepatitis through extracellular vesicles. Hepatology. 2024 Nov 7. doi: 10.1097/HEP.0000000000001149. Epub ahead of print. PMID: 39509377. (SCIE)
  • Lin, YY., Chang, WH., Hsieh, SL*. et al.The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model. J Neuroinflammation 21, 273 (2024). (SCIE) https://doi.org/10.1186/s12974-024-03253-x
  • Chang, CM., Chang, WC. & Hsieh, S. Characterization of the genetic variation and evolutionary divergence of the CLEC18 family. J Biomed Sci 31, 53 (2024). https://doi.org/10.1186/s12929-024-01034-5. (SCIE)
  • Sung PS, Sun CP, Tao MH, Hsieh SL*, 2023, “Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc”, EMBO MOLECULAR MEDICINE, e16351, 1-16. (SCIE)
  • Wang HW, Li HH, Wu SC, Tang CK, Yu HY, Chang YC, Sung PS, Liu WL, Su MP, Yu GY, Huang LR, Chen CH*, Hsieh SL*, 2023, “CLEC5A mediates Zika virus‑induced testicular damage”, JOURNAL OF BIOMEDICAL SCIENCE, 30: 12, 1-16. (SCIE)
  • Sung PS, Peng YC, Yang SP, Chiu CH, Hsieh SL*, 2022, “CLEC5A is critical in Pseudomonas aeruginosa-induced NET formation and acute lung injury”, JCI INSIGHT, 7(18), e156613. (SCIE)
  • Sung PS, Yang SP, Perng YC, Sun CP, Tao MH, Hsieh SL*, 2022, “CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation”, JOURNAL OF BIOMEDICAL SCIENCE, 29(1), 52. (SCIE)
  • Hsu YW, Huang H CH, Huang WC, Yeh YH, Hsiao CD, Chang WC**, Hsieh SL**, 2022, “Human rs75776403 Polymorphism Links Differential Phenotypic and Clinical Outcomes to a CLEC18A p.T151M-Driven Multiomics”, JOURNAL OF BIOMEDICAL SCIENCE, 29(1), 43. (SCIE)
  • Sung PS, Hsieh SL*, 2021, “C-type lectins and extracellular vesicles in virus-induced NETosis”, JOURNAL OF BIOMEDICAL SCIENCE, 28(1), 46. (SCIE)
  • Tsai TY, Huang MT, Sung PS, Peng CY, Tao MH, Yang HI, Chang WC, Yang AS, Yu CM, Lin YP, Ching-Yu Bau3, Huang CJ, Pan MH, Wu CY, Hsiao CD, Yeh YH, Shiteng Duan, James C Paulson, Hsieh SL*, 2021, “Siglec-3 (CD33) is the immune checkpoint receptor in HBV infection”, JOURNAL OF CLINICAL INVESTIGATION, 131(11), 141965. (SCIE)
  • Pan YG, Huang MT, P. Sekar, Huang DY, Lin WW, Hsieh SL*, 2021, “Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture”, FRONTIERS IN IMMUNOLOGY, 12: 638676, 1-16. (SCIE)
  • Huang YL , Huang MT, Sung PS, Chou TY, Yang RB, Yang AS, Yu CM, Hsu YW, Chang WC, Hsieh SL*, 2021, “Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection”, Communications biology, 4(1): 229, 1-13. (SCIE)
  • Hsieh SL, 2020, Lectin in Host Defense Against Microbial Infections, Advances in Experimental Medicine and Biology, 230 pages, Singapore: Springer Nature Singapore Pte Ltd.
  • Sung PS, Chang WC, Hsieh SL*, 2020, “CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond”, editor(s): (Hsieh SL), Lectin in Host Defense Against Microbial Infections, Advances in Experimental Medicine and Biology, pp. 1204: 57-73, 新加坡: Springer Nature Singapore Pte Ltd.
  • Sung PS, Hsieh SL*, 2019, “CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections”, FRONTIERS IN IMMUNOLOGY, 10: 2867, 1-9. (SCIE)
  • Sung PS, Huang TF, Hsieh SL*, 2019, “Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2”, NATURE COMMUNICATIONS, 10(1): 2402, 1-13. (SCIE)
  • Tsai TY, Peng CY, Yang HI, Huang YL, Tao MH, Yuan SS, Lai HC, Hsieh SL*, 2018, “The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection”, JOURNAL OF BIOMEDICAL SCIENCE, 25(1): 59, 1-10. (SCIE)
  • Tsai HW, Huang MT, Wang PH, Huang BS, Chen YJ, Hsieh SL*., 2018, “Decoy receptor 3 promotes cell adhesion and enhances endometriosis development”, JOURNAL OF PATHOLOGY, 244(2), 189-202. (SCIE)
  • Chen ST, Chen JW, Wu WC, Chou TY, Yang CY, Hsieh SL*, 2017, “CLEC5A is a critical receptor in innate immunity against Listeria infection”, NATURE COMMUNICATIONS, 8(1): 299, 1-13. (SCIE)
  • Chiu CW, Cheng H, Hsieh SL*, 2017, “Contusion spinal cord injury rat model”, Bio-protocol, 7(12), e2337.
  • Lai JH, Lin YL, Hsieh SL* , 2017, “Pharmacological intervention for dengue virus infection”, BIOCHEMICAL PHARMACOLOGY, 129, 14-25. (SCIE)
  • Teng, O, Chen, ST, Hsu TL, Sia SF, Cole S, Valkenburg SA, Hsu TY, Zheng JT, Tu W, Bruzzone R, Peiris JSM, Hsieh SL*, Yen HL*, 2017, “CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo”, JOURNAL OF VIROLOGY, 91(1), e01813-e01816. (SCIE)
  • Tung YL, Wu MF, Wang GJ*, Hsieh SL*, 2014, “Nanostructured electrochemical biosensor for the detection of the weak binding between the dengue virus and the CLEC5A receptor”, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 10(6), 1335-1341. (SCIE)
  • Chen DY, Yao L, Chen YM, Lin CC, Huang KC, Chen ST, Lan JL*, Hsieh SL*, 2014, “A Potential Role of Myeloid DAP12-Associating Lectin (MDL)-1 in the Regulation of Inflammation in Rheumatoid Arthritis Patients”, PLoS One, 9(1): e86105, 1-11. (SCIE)
  • Yang CY, Chen JB, Tsai TF, Tsai YC, Tsai CY, Liang PH, Hsu TL, Wu CY, Netea MG, Wong CH, Hsieh SL*, 2013, “CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver”, PLoS One, 8(6): e65070, 1-14. (SCIE)
  • Wu MF, Chen ST, Hsieh SL*, 2013, “Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets”, JOURNAL OF BIOMEDICAL SCIENCE, 20(1): 36, 1-9. (SCIE)
  • Wu MF, Chen ST, Yang AH, Lin WW, Lin YL, Chen NJ, Tsai IS, Li L, Hsieh SL*, 2013, “CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages”, BLOOD, 121(1), 95-106. (SCIE)
  • Chen ST, Liu RS, Wu MF, Lin YL, Chen SY, Tan DT, Chou TY, Tsai IS, Li L, Hsieh SL*, 2012, “CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality”, PLOS PATHOGENS, 8(4): e1002655, 1-18. (SCIE)
  • Tai SK, Chang HC, Lan KL, Lee CT, Yang CY, Chen NJ, Chou TY, Tarng DC, Hsieh SL*, 2012, “Decoy receptor 3 enhances tumor progression via induction of tumor-associated macrophages”, JOURNAL OF IMMUNOLOGY, 188(5), 2464-2471. (SCIE)
  • Chen ST , Lin YL , Huang MT , Wu MF , Hsieh SL*, 2011, “Targeting C-type lectin for the treatment of flaviviral infections.”, editor(s): Albert M. Wu, The Molecular Immunology of Complex Carbohydrates-3, pp. 769-776, USA: Springer.
  • Lin WW, Hsieh SL*, 2011, “Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer”, BIOCHEMICAL PHARMACOLOGY, 81(7), 838-847. (SCIE)
  • Lee RT, Hsu TL, Huang SK, Hsieh SL, Wong CH, Lee YC*, 2011, “Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities”, GLYCOBIOLOGY, 21(4), 512-520. (SCIE)
  • Hsu TL, Cheng SC, Yang WB, Chin SW, Chen BH, Huang MT, Hsieh SL*, Wong CH*, 2009, “Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins”, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(50), 34479-34489. (SCIE)
  • Chen CY, Yang KY, Chen MY, Chen HY, Lin MT, Lee YC, Perng RP, Hsieh SL, Yang PC, Chou TY*, 2009, “Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome”, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180(8), 751-760. (SCIE)
  • Wu MF, Yang CY, Lin TL, Wang JT, Yang FL, Wu SH, Hu BS, Chou TY, Tsai MD, Lin CH, Hsieh SL*, 2009, “Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling”, INFECTION AND IMMUNITY, 77(2), 615-621. (SCIE)
  • Tsai CM, Chiu YK, Hsu TL, Lin IY, Hsieh SL, Lin KI*, 2008, “Galectin-1 promotes immunoglobulin production during plasma cell differentiation”, JOURNAL OF IMMUNOLOGY, 181(7), 4570-4579. (SCIE)
  • Chang PM, Chen PM, Hsieh SL, Tzeng CH, Liu JH, Chiou TJ, Wang WS, Yen CC, Gau JP, Yang MH*, 2008, “Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome”, INTERNATIONAL JOURNAL OF ONCOLOGY, 33(3), 549-554. (SCIE)
  • Hsieh SL*, 2008, “Decoy Receptor 3 (DcR3): A Pleiotropic Immunomodulator”, BLOOD, 112(3), 916-917. (SCIE)
  • Chang YC, Chen TC, Lee CT, Yang CY, Wang HW, Wang CC, Hsieh SL*, 2008, “Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3”, BLOOD, 111(10), 5054-5063. (SCIE)
  • Lee CS, Hu CY, Tsai HF, Wu CS, Hsieh SL, Liu LC, Hsu PN*, 2008, “Elevated serum decoy receptor 3 with enhanced T cell activation in systemic lupus erythematosus”, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 151(3), 383-390. (SCIE)
  • Wang SK, Liang PH, Astronomo RD, Hsu TL, Hsieh SL, Burton DR, Wong CH*, 2008, “Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(10), 3690-3695. (SCIE)
  • You RI, Chang YC, Chen PM, Wang WS, Hsu TL, Yang CY, Lee CT, Hsieh SL*, 2008, “Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3)”, BLOOD, 111(3), 1480-1488. (SCIE)
  • 專書Books/Book Chapters:
  • Shie-Liang Hsieh*: Lectins in Host-Pathogen Interaction (Editor, Springer Publisher, to be completed in 2018)
  • Shie-Liang Hsieh*“C-Type Lectin Receptors in Immunity” Chapter 3: C-type lectin member 5A. 2016 (editor: Sho Yamasaki) Springer Publisher Ltd. ISBN 978-4-431-56015-9
  • Szu-Ting Chen, Yi-Ling Lin, Ming-Ting Huang, Ming-Fang Wu, Shie-Liang Hsieh*(2011). “The Molecular Immunology of Complex Carbohydrates-3” Chapter 40: Targeting C-Type Lectin for the Treatment of Flavivirus Infections. Springer Publisher Ltd. ISBN 978-1-4419-7877-6

研究方向

我的實驗室致力於研究微生物感染、癌症侵襲和自體免疫反應的關鍵受體，並生產抗體作為治療性藥物。由於纖維化是慢性炎症的後果，並會導致器官功能障礙，因此我們也生產免疫調節劑，將巨噬細胞分化成M2，以促進組織修復。

實驗室照片